Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling.

The Brn-3 subfamily of POU domain genes are expressed in sensory neurons and in select brainstem nuclei. Earlier work has shown that targeted deletion of the Brn-3b and Brn-3c genes produce, respectively, defects in the retina and in the inner ear. We show herein that targeted deletion of the Brn-3a gene results in defective suckling and in uncoordinated limb and trunk movements, leading to early postnatal death. Brn-3a (-/-) mice show a loss of neurons in the trigeminal ganglia, the medial habenula, the red nucleus, and the caudal region of the inferior olivary nucleus but not in the retina and dorsal root ganglia. In the trigeminal and dorsal root ganglia, but not in the retina, there is a marked decrease in the frequency of neurons expressing Brn-3b and Brn-3c, suggesting that Brn-3a positively regulates Brn-3b and Brn-3c expression in somatosensory neurons. Thus, Brn-3a exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. The pheno-types of Brn-3a, Brn-3b, and Brn-3c mutant mice indicate that individual Brn-3 genes have evolved to control development in the auditory, visual, or somatosensory systems and that despite differences between these systems in transduction mechanisms, sensory organ structures, and central information processing, there may be fundamental homologies in the genetic regulatory events that control their development.

The evolution of emergent computation.

A simple evolutionary process can discover sophisticated methods for emergent information processing in decentralized spatially extended systems. The mechanisms underlying the resulting emergent computation are explicated by a technique for analyzing particle-based logic embedded in pattern-forming systems. Understanding how globally coordinated computation can emerge in evolution is relevant both for the scientific understanding of natural information processing and for engineering new forms of parallel computing systems.

Research in speech communication.

Advances in digital speech processing are now supporting application and deployment of a variety of speech technologies for human/machine communication. In fact, new businesses are rapidly forming about these technologies. But these capabilities are of little use unless society can afford them. Happily, explosive advances in microelectronics over the past two decades have assured affordable access to this sophistication as well as to the underlying computing technology. The research challenges in speech processing remain in the traditionally identified areas of recognition, synthesis, and coding. These three areas have typically been addressed individually, often with significant isolation among the efforts. But they are all facets of the same fundamental issue--how to represent and quantify the information in the speech signal. This implies deeper understanding of the physics of speech production, the constraints that the conventions of language impose, and the mechanism for information processing in the auditory system. In ongoing research, therefore, we seek more accurate models of speech generation, better computational formulations of language, and realistic perceptual guides for speech processing--along with ways to coalesce the fundamental issues of recognition, synthesis, and coding. Successful solution will yield the long-sought dictation machine, high-quality synthesis from text, and the ultimate in low bit-rate transmission of speech. It will also open the door to language-translating telephony, where the synthetic foreign translation can be in the voice of the originating talker.

Contexto e modularização em redes neurais recorrentes para aprendizagem de seqüências temporais

Este trabalho apresenta um sistema neural modular, que processa separadamente informações de contexto espacial e temporal, para a tarefa de reprodução de sequências temporais. Para o desenvolvimento do sistema neural foram considerados redes neurais recorrentes, modelos estocásticos, sistemas neurais modulares e processamento de informações de contexto. Em seguida, foram estudados três modelos com abordagens distintas para aprendizagem de seqüências temporais: uma rede neural parcialmente recorrente, um exemplo de sistema neural modular e um modelo estocástico utilizando a teoria de modelos markovianos escondidos. Com base nos estudos e modelos apresentados, esta pesquisa propõe um sistema formado por dois módulos sucessivos distintos. Uma rede de propagação direta (módulo estimador de contexto espacial) realiza o processamento de contexto espacial identificando a seqüência a ser reproduzida e fornecendo um protótipo do contexto para o segundo módulo. Este é formado por uma rede parcialmente recorrente (módulo de reprodução de sequências temporais) para aprender as informações de contexto temporal e reproduzir em suas saídas a seqüência identificada pelo módulo anterior. Para a finalidade mencionada, este mestrado utiliza a distribuição de Gibbs na saída do módulo para contexto espacial de forma que este forneça probabilidades de contexto espacial, indicando o grau de certeza do módulo e possibilitando a utilização de procedimentos especiais para os casos de dúvida. O sistema neural foi testado em conjuntos contendo trajetórias abertas, fechadas, e com diferentes situações de ambigüidade e complexidade. Duas situações distintas foram avaliadas: (a) capacidade do sistema em reproduzir trajetórias a partir de pontos iniciais treinados; e (b) capacidade de generalização do sistema reproduzindo trajetórias considerando pontos iniciais ou finais em situações não treinadas. A situação (b) é um problema de difícil ) solução em redes neurais devido à falta de contexto temporal, essencial na reprodução de seqüências. Foram realizados experimentos comparando o desempenho do sistema modular proposto com o de uma rede parcialmente recorrente operando sozinha e um sistema modular neural (TOTEM). Os resultados sugerem que o sistema proposto apresentou uma capacidade de generalização significamente melhor, sem que houvesse uma deterioração na capacidade de reproduzir seqüências treinadas. Esses resultados foram obtidos em sistema mais simples que o TOTEM.

Attentional processes associated with victimization history and posttraumatic symptomatology in women exposed to intimate partner violence

Exposure to intimate partner violence (IPV) puts women at risk for severe and chronic physical and mental health consequences, including elevations in IPV-related psychopathology and increased risk for future victimization. Previous research has examined attention as one of the key information processing mechanisms associated with elevated psychopathology and risk for victimization; however, the nature of attentional processing in response to IPV-related information in women exposed to IPV is poorly understood. Therefore, the current study aimed to further understanding of associations between attentional processing, IPV exposure, and related distress using measures of eye movement and subjective interpretations of IPV-related information. A sample of women exposed to IPV (n = 57) viewed sets of negative, positive, and neutral relationship images for 15 s each while having their eye movements monitored and later provided subjective ratings and interpretations of levels of risk and safety in those images. We examined associations of outcome measures with proximal victimization experiences and IPV-related psychopathology (i.e., depression, posttraumatic stress disorder (PTSD), anxiety, and dissociation). Results indicated a bias to attend to negative relationship images relative to positive and neutral images, though this attention bias fluctuated over time and varied as a function of symptomatology such that depression corresponded with increases in attention to negative images over time and PTSD corresponded with decreases in attention to negative images. The general attention bias for negative images appeared to be explained by rumination on and/or difficulty disengaging from negative images, which was related to general elevations in psychopathology as well as exposure to revictimization by different perpetrators. Subjective interpretations and perception of danger cues were related to victimization history and level and type of IPV-related distress. We replicated these procedures with a sample of undergraduate students without IPV histories or related symptomatology (n = 33) and found that the overall attention bias for negative images was not replicated, despite general similarities in patterns of attention over time. Results therefore indicated associations between attentional processing and IPV exposure and related symptomatology. Implications for models of IPV-related psychopathology and attentional processing as well as directions for future study and interventions are discussed.

TextMess 2.0: las tecnologías del lenguaje humano ante los nuevos retos de la comunicación digital

El objetivo general de este proyecto se centra en el estudio, desarrollo y experimentación de diferentes técnicas y sistemas basados en Tecnologías del Lenguaje Humano (TLH) para el desarrollo de la próxima generación de sistemas de procesamiento inteligente de la información digital (modelado, recuperación, tratamiento, comprensión y descubrimiento) afrontando los actuales retos de la comunicación digital. En este nuevo escenario, los sistemas deben incorporar capacidades de razonamiento que descubrirán la subjetividad de la información en todos sus contextos (espacial, temporal y emocional) analizando las diferentes dimensiones de uso (multilingualidad, multimodalidad y registro).

Tratamiento inteligente de la información para ayuda a la toma de decisiones

Proyecto emergente centrado en el tratamiento inteligente de información procedente de diversas fuentes tales como micro-blogs, blogs, foros, portales especializados, etc. La finalidad es generar conocimiento a partir de la información semántica recuperada. Como resultado se podrán determinar las necesidades de los usuarios o mejorar la reputación de diferentes organizaciones. En este artículo se describen los problemas abordados, la hipótesis de trabajo, las tareas a realizar y los objetivos parciales alcanzados.

A Life Cycle Approach to Investor Protection. ECMI Working Paper No. 1/September 2014

The market for investment products, including both securities and investment funds, is fraught with difficulties for consumers in terms of the ease of comparing products, trust in suppliers and consumer satisfaction. A comprehensive approach to investor protection, developed around the lifecycle of a financial product, may offer the investor greater protection during an investment’s life span. This paper proposes a new approach to investor protection, building on a review of major market failures affecting the origination, distribution and sale of financial products and based on a review of the relevant scientific literature and country experiences. The application of a ‘know-your-product’ principle at origination, a narrower ‘default rule’ for best execution and an ex-ante distinction between advice and ‘information-only’ services are among the options discussed in this paper to enhance the investor protection framework over the lifecycle of a financial product.

Has the European ICT sector a chance to be competitive? Bruges European Economic Policy (BEEP) Briefing 14/2006

In this paper we try to present the main trends of evolution of the ICT sector. Its dynamics, supported by a constant technical progress in ICs, compounded with “non convexities” such as network effects and high sunk costs, may either lead to a Schumpeter Mark I or Schumpeter Mark II competition regime. This means that in some segments, the market will be more competitive (Mark I), while in other it will be more monopolistic (Mark II). But a key trend is also the so called “convergence”. But digitization makes it cost effective to integrate different communications, information processing and entertainment systems and devices. Hence, Schumpeter Mark II grows at the core where software production dominates, while Schumpeter Mark I is established at the periphery. In this context, the European ICT industry is potentially smashed between two forces: the cost advantages of Asian countries on one hand, the inventiveness and dynamism of the US industry on the other hand. The way out of this very difficult situation is to create in Europe the conditions of restoring knowledge accumulation in a key sub-sector of ICT, that is software production. To do this, Europe can rely on its tradition of cooperation and knowledge sharing and on a set of institutions that have shown their ability to stimulate inter-regional cooperation. By concentrating on an ambitious project of open source software production in embarked systems and domestic networks, Europe could reach several objectives: to make freely accessible an essential facility, to stimulate competition, to help reaching the Lisbon objectives and to restore the European competitiveness in ICT.

O uso de indicadores de sustentabilidade no gerenciamento de projetos de tecnologia da informação

As técnicas de gerenciamento de projetos empregadas no controle e monitoramento durante o ciclo de vida de um projeto, em sua forma mais tradicional, são realizadas levando em consideração a tríplice restrição (escopo, tempo e custo) em busca do pleno atendimento às linhas de bases estabelecidas preliminarmente nas fases de planejamento dos projetos, sejam eles de Tecnologia da Informação (TI) ou de quaisquer naturezas. O desempenho dos projetos da Tecnologia da Informação pode sofrer maiores impactos devido ao alto grau de complexidade e devido à intangibilidade dos mesmos; aliado a isso e com o crescente avanço de estudos de sustentabilidade aplicados à diversas áreas de projeto, incluindo-se à estes os projetos de TI, este trabalho tem como tema central identificar como as empresas de TI aplicam os indicadores de sustentabilidade nos processos de gerenciamento de projetos de tecnologia da informação. O objetivo geral é verificar a presença do uso de indicadores de sustentabilidade em projetos de TI em empresas prestadoras de serviços de tecnologia da informação, e os específicos são: (i) analisar a existência de indicadores de sustentabilidade utilizados nos projetos de TI; (ii) compreender a relação dos indicadores de sustentabilidade com os projetos de TI; e (iii) verificar as contribuições do uso de indicadores de sustentabilidade nos projetos de TI. A abordagem do trabalho será de origem qualitativa e exploratória, realizada por meio de um estudo de múltiplos casos a ser aplicado em empresas prestadoras de serviços do segmento de Tecnologia da Informação. Concluiu-se que as organizações possuem de fato a aplicação de indicadores de sustentabilidade em nível organizacional na gestão de projetos de TI, porém, nenhum dos casos abordados apresenta a presença de indicadores específicos a projetos TI, dessa forma somente fazendo parte de um conjunto geral de indicadores e com maior a menor intensidade dependendo da natureza envolvida no projeto de tecnologia da informação.

Auditory message studies for route diversion. Final report.

Mode of access: Internet.

Driver expectancy in highway design and traffic operations. Final report.

Mode of access: Internet.

Alternative sign sequences for work zones on rural highways. Executive summary. Final report.

Federal Highway Administration, Office of Research and Development, Washington, D.C.

Highway geometric design consistency related to driver expectancy. Volume I: executive summary. Final report.

Federal Highway Administration, Environmental Division, Washington, D.C.

Highway geometric design consistency related to driver expectancy. Volume II: research report. Final report.

Federal Highway Administration, Environmental Division, Washington, D.C.