The Effects of Social Anxiety on the Development of Romantic Relationships in Adolescence

The present study sought to investigate the ways in which social anxiety impedes the development of romantic relationships across adolescence. Previous research has demonstrated a natural progression for romantic associations during adolescence in which teens transition from same- to mixed-sex peer groups, and finally to dyadic relationships with romantic partners (Connolly, Furman, Konarski, 2000; Dunphy, 1963). This model of development was the basis for the present investigation. Social anxiety was examined in terms of how it impacted affiliations at the same- and mixed sex peer group levels, and ultimately the formation of romantic relationships. This project involved administering a series of questionnaires and rating scales to students enrolled in the 9th through \2l grades. Participants included 457 adolescents (196 males, 261 females) recruited from public high schools in the state of Maine. The questionnaires assessed social anxiety, peer acceptance, heterosocial competence, gender composition of adolescent peer networks, dating history, and relationship quality with significant others in the adolescent's life. Higher levels of social anxiety were expected to be associated with impairment at each of these three levels. Given the proposed developmental progression, the effects of anxiety were theorized to be most pronounced within the older cohort of adolescents. Moreover, gender was expected to affect the pattern of results. Social anxiety is most prevalent among females (LaGreca, 1998; LaGreca & Lopez, 1998), who are also thought to progress along the proposed developmental trajectory more quickly than their male counterparts. Therefore, social anxiety was expected to impact the females to a greater degree at each of the three levels. Correlation coefficients, multivariate analyses of variance, and regression analyses were used to evaluate the data. Overall, despite some discrepant findings, the results supported the hypotheses. Social anxiety was affiliated with problems in the same-sex peer group, the mixed-sex clique, and, for older adolescents, romantic relationships. As expected, social anxiety affected females the most at each level. There seems to be a maladaptive pathway that socially anxious teens are following that is markedly different than their non-anxious counterparts.

The functions of pitx2 and Bmp signaling in craniofacial development

The formation of the vertebrate face is an extremely complex developmental process, which needs to coordinate the outgrowth of several facial primordia. Facial primordia are small buds made up of mesenchymal masses enclosed by an epithelial layer that surrounds the primitive mouth. The upper jaw is formed by the maxillary process, the lateral nasal process, and the frontonasal process while the mandibular process forms the lower jaw. Recent experiments using genetics in mice and bead implantation approaches have shown that the pitx2 homeobox gene and Bmp signaling play important roles in this complex developmental process. However, the molecular mechanisms underlying the function of pitx2 and Bmp in these events are still unclear. Here, we show that pitx2 is required for oral epithelium maintenance, and branchial arch signaling is pitx2 dosage sensitive by using pitx2 allelic combinations that encode varying levels of pitx2. Maintenance of fgf8 signaling requires only low pitx2 dosage while repression of Bmp signaling requires high pitx2 levels. Different incisor and molar phenotypes in low level pitx2 mutant embryos suggest a distinct requirement for pitx2 in tooth-type development. The results show that pitx2 is required for craniofacial muscle formation and expanded Bmp signaling results in excess bone formation in pitx2 mutant embryos. Fate-mapping studies show that ectopic bone results from excessive bone growth, instead of muscle transformation. Moreover, by using cre/loxp system we show that partial loss of Bmpr-IA in the facial primordia results in cleft lip/palate, abnormal teeth, ectopic teeth and tooth transformation. These phenotypes suggest that Bmp signaling has multiple functions during craniofacial development. The mutant palate shelves can fuse with each other when cultured in vitro, suggesting that cleft palate is secondary to the partial loss of Bmpr-IA. Furthermore, we prove that Bmp4, one of the ligands of Bmpr-IA, plays a role during lip fusion developmental process and partial loss of Bmp4 in the facial primordia results in the lip fusion delay. These results have provided insight to understand the complex signaling cascades that regulate craniofacial development. ^

Joint Attention in Young Children with Autism

Autism spectrum disorders (ASDs) are classified as pervasive developmental disorders characterized by social, communicative, and behavioral impairments. According to formal and informal reports, children with ASD present with receptive and expressive language delay. Joint attention (JA: the behavior that occurs when two individuals focus on the same object or event) has been identified as a possible marker of delayed language development in children with ASD. In this study, the JA behaviors in children with ASD were contrasted with initially language-matched typically developing (TYP) children across three visits. Measures of language, the frequency, duration, and source of initiation of JA episodes, and the choice of toy during those episodes, were coded. Across visits and groups, mothers initiated more JA episodes than children; however, typical children also initiated more JA episodes than ASD children at visits 1 and 2. Also, the total duration of typically developing children’s JA episodes was generally longer than that of the ASD children’s, significantly so at Visit 2. Significant associations emerged between children’s vocabulary and two measures of JA: frequency and number of maternal initiations. Teaching parents to incorporate JA training in their interactions with their children may likely help children with ASD acquire language.

Season of Birth Effects in Autism Spectrum Disorders

One factor that is investigated as a possible clue to etiological factors in Autism Spectrum Disorders (ASD) is season of birth. Season of birth effects could be the result of temperature, toxins, dietary changes, viral infections, and cultural or social factors that change seasonally (Bolton, Pickles, Harrington, Macdonald, & Rutter, 1992). A number of studies have looked for season of birth effects in ASD with no conclusive results. The current study analyzed season of birth effects in a sample of 441 children diagnosed with ASD. Analysis was also repeated after excluding prematurely born children from the data. Level of functioning and gender effects were tested by breaking the sample into a number of sub-groups. While there were no season of birth effects in the sample of all children with ASD when compared to children without ASD in either the entire sample or the non-premature sample, there were significant differences in the season of birth of low functioning children with ASD when compared with high functioning children with ASD.

Na 1 Nachlass Max Horkheimer, 636 - "The Relation between Philosophy and Sociology in the Work of Wilhelm Dilthey" und "Autoritärer Staat" (p. IX 12.1-7-IX 13.1-7)

"The Relation between Psychology and Sociology in the Work of Wilhelm Dilthey" (GS 4, S. 352-370), veröffentlicht in Studies in Philosophy and Social Science VIII, 1939/40, S. 430-443, Vortragstext englische Fassung, Typoskript mit eigenhändigen Korrekturen, 18 Blatt, deutsche Fassung, Typoskript mit eigenhändigen Korrekturen, 20 Blatt; Vorlage zur Eröffnung der Vortragsveranstaltung, Typoskript, 1 Blatt; Über das Verhältnis Diltheys zu Max Weber; über die Widersprüche bei Dilthey; zur Logik geisteswissenschaftlichen Verstehens (= Vorarbeiten zum Vortrag? Vorbereitungen zu Diskussionsbeiträgen?), a) englische Fassung, Typoskript, 5 Blatt, b) deutsche Fassung, Typoskript, 6 Blatt; N.N.: handschriftliche Notiz für die Diskussion, 1 Blatt; Exzerpte zum Werk Wilhelm Diltheys, Typoskripte, 12 Blatt; Zitate aus Schriften Wilhelm Diltheys, Typoskripte, 12 Blatt; Deutsche Übersetzung des Aufsatzes von Kurt Jürgen Huch und Alfred Schmidt, mit dem Titel: "Der Zusammenhang zwischen Psychologie und Soziologie im Werk Wilhelm Diltheys", veröffentlicht in: Max Horkheimer, "Kritische Theorie", Bd. II, 1968, S.273-291, Typoskript mit handschriftlichen Korrekturen, 29 Blatt; "Autoritärer Staat" (GS 5, S. 293-319), Aufsatz, datiert: Frühjahr 1940, veröffentlicht als vervielfältigtes Typoskript in "Walter Benjamin zum Gedächtnis", herausgegeben vom Institut für Sozialforschung, Los Angeles 1942, S. 123-161;

Identification and characterization of Xenopus Kazrin, a nucleocytoplasmic shuttling protein that interacts with ARVCF catenin

In common with other members of the p120-catenin subclass of catenins, ARVCF-catenin appears to have multiple cellular and developmental functions. In Xenopus, our lab recently demonstrated that xARVCF- and Xp120-catenins are each essential for early vertebrate embryogenesis, being functionally linked to Rho-family GTPases (RhoA, Rac) and cadherin metabolic stability. For the project described here, the yeast two-hybrid system was employed to screen a Xenopus laevis neurula library for proteins that interact with xARVCF, resulting in the identification of the Xenopus homolog of Kazrin (xKazrin). Kazrin is a variably-spliced protein of unknown function that has been shown to interact with periplakin and envoplakin, components of desmosomal junctions. Kazrin's primary sequence is highly conserved across vertebrate species and is composed of an amino-terminal nuclear export sequence (NES), a carboxy-terminal nuclear localization sequence (NLS) and a central predicted coiled-coil domain. In vitro and in vivo authenticity tests demonstrated that xARVCF-catenin interacts directly with xKazrin via xARVCF's Armadillo and carboxy-terminal regions and xKazrin's coiled-coil domain. The interaction of xARVCF-catenin with xKazrin is specific and does not extend to the related Xp120-catenin. xKazrin co-localized with E-cadherin at sites of cell-cell contact and could be co-immunoprecipitated with components of the cadherin complex. xKazrin was also present in the cytoplasm and nucleus. Suggestive of a nuclear role, mutation of xKazrin's predicted NLS resulted in nuclear exclusion, while deletion of the predicted NES resulted in loss of sensitivity to nuclear export inhibitors. Within Xenopus embryos, xKazrin was expressed across all developmental stages and appeared at varying levels in adult tissues. Morpholino depletion of xKazrin from Xenopus embryos resulted in axial elongation abnormalities and loss of tissue integrity after neurulation. Over-expression of xKazrin had no effect, while over-expression of a NLS mutant resulted in a mild phenotype similar to that seen in xKazrin depleted embryos. Interestingly, the axial phenotype resulting from reduced xKazrin levels was largely rescuable by xARVCF over-expression. In conjunction with xARVCF-catenin, xKazrin has properties consistent with its function at cell-cell contact sites and in the nucleus. ^

Polybrominated diphenyl ethers: Potential human exposure through household dust and dryer lint

This MPH thesis consists of (1) literature review of the relatively new synthetic persistent organic pollutants (POP), polybrominated diphenyl ethers (PBDEs), a type of flame retardant posing a potential public health hazard, (2) Presentation of data on PBDE levels in dryer lint from Dallas, TX and Hamburg, Germany. ^ PBDEs are used as additive fire retardants in plastics, polyurethane foam and electronic equipment to reduce flammability and thus save life and property. PBDEs have been widely used beginning in the 1970s. They resemble polychlorinated biphenyls (PCBs) in structure and toxicity. PBDEs are found in environmental sediments, sludges, and wildlife and even in human blood, milk and tissues. ^ PBDEs, due to their lipophilicity, accumulate in fat and other tissues and biomagnify up the food chain, with increasing concentrations. Animal studies have suggested potential health effects including thyroid disruption, permanent learning and memory impairment, fetal malformations, developmental neurotoxicity and, at high doses, possibly cancer. ^ PBDE levels are increasing in blood and breast milk in North America, but PBDEs intake unlike PCBs appears to be not primarily through food; food PBDE levels in the U.S. are not markedly higher than in Europe yet U.S. human blood and milk levels are much higher. For this reason various exposure pathways including PBDE contaminated dust and air have been studied to better characterize routes of PBDE intake into humans. ^ The scientific literature on PBDE levels in household dust reports higher PBDE concentration in dust than that found in dryer lint; levels in the U.S are elevated compared to other countries with congeners such as BDE 47, 99, 100 and 209 predominating. The United Kingdom has elevated BDE 209 due to high usage of Deca commercial mixture. These studies suggest that indoor PBDE contamination through household dust could be a potential source of PBDE exposure and body burden especially in young children. ^ PBDE levels in dryer lint from U.S ranged from 321 to 3073 ng/g (Mean: 1138 ng/g, Median: 803 ng/g) and from Germany were from 330 to 2069 ng/g (Median: 71ng/g, Mean: 361 ng/g). High median levels in U.S samples indicate contamination of lint with PBDEs although the source of the PBDEs in lint may be from dryer electrical components or air deposition onto clothes, lint may be one source of PBDE exposure to humans. ^

Editorial: Roles and Expertise

We all take on roles, probably several each day. Parent, worker, consumer, spouse, or shortstop, the roles we play are varied and complex. After one's own family, perhaps the roles of consumer and worker are most important to Family Preservation. How do we come to play these roles, and in what ways are they changing, or should they change? Often, neither the worker or family set out to play their roles, but through the twist and turns of life, the opportunity to serve and preserve a family presents itself. At a recent conference, a group of workers spoke of how, rather than having a career goal to do Family Preservation, Family Preservation found them. Many of the families probably say the same thing! In the fields of mental health, developmental disabilities, and adoption, families may seek Family Preservation services; rarely do families involved in juvenile justice, corrections, or child welfare systems look for Family Preservation. Family Preservation finds them. And thus the roles begin.

Subjective well -being as predictor of mortality, heart disease, and obesity: Prospective evidence from the Alameda County Study

Based on the World Health Organization's (1965) definition of health, understanding of health requires understanding of positive psychological states. Subjective Well-being (SWB) is a major indicator of positive psychological states. Up to date, most studies of SWB have been focused on its distributions and determinants. However, study of its consequences, especially health consequences, is lacking. This dissertation research examined Subjective Well-being, as operationally defined by constructs drawn from the framework of Positive Psychology, and its sub-scores (Positive Feelings and Negative Feelings) as predictors of three major health outcomes—mortality, heart disease, and obesity. The research used prospective data from the Alameda County Study over 29 years (1965–1994), based on a stratified, randomized, representative sample of the general public in Alameda County, California (Baseline N = 6928). ^ Multivariate analyses (Survival analyses using sequential Cox Proportional Hazard models in the cases of mortality and heart disease, and sequential Logistic Regression analyses in the case of obesity) were performed as the main methods to evaluate the associations of the predictors and the health outcomes. The results revealed that SWB reduced risks of all-cause mortality, natural-cause mortality, and cardiovascular mortality. Positive feelings not only had an even stronger protective effect against all-cause, natural-cause and cardiovascular mortality, but also predicted decreased unnatural-cause mortality which includes deaths from suicide, homicide, accidents, mental disorders, drug dependency, as well as alcohol-related liver diseases. These effects were significant even after adjusted for age, gender, education, and various physical health measures, and, in the case of cardiovascular mortality, obesity and health practices (alcohol consumption, smoking, and physical activities). However, these two positive psychological indicators, SWB and positive feelings, did not predict obesity. And negative feelings had no significant effect on any of the health outcomes evaluated, i.e., all-cause mortality, natural- and unnatural-cause mortality, cardiovascular mortality, or obesity, after covariates were controlled. These findings were discussed (1) in comparison with relevant existing studies, (2) in terms of their implications in health research and promotion, (3) in terms of the independence of positive and negative feelings, and (4) from a Positive Psychology perspective and its significance in Public Health research and practice. ^

Vocation in the insertion of the university student and the graduate

The work plan aims at deepening the analysis of the theoretic assumptions which support the practice in Vocational Guidance: analyzing the incidence of endogenous and exogenous factors both in the election and studying of a particular course of study and in the occupational resolution of the graduate. This analysis enables the revision and the new theoretic conceptualization which is afterwards transferred to the course, and to different groups and provincial institutions where the practice of Vocational Guidance occurs, as well as to other schools in the Northwest provinces of Argentina. Semiotic analysis, statistical elaboration and the research-action approach which, while surveying data renders a service to the milieu, provide the base for the project. Said project focuses on the following individuals: 1) freshmen, who offer us the following aspects to be considered: a) factors which either favor or hinder the insertion of the students attending the first years of the course; b) the conditions making up the learning situation in each subject, from the teaching point of view; c) the influence of institutional dimension in the insertion process; 2) graduands: the characteristics of the situation following graduation from University, those of the labor field and the different ways of gaining access to it are investigated. This analysis is carried out in the courses of study of Psychology and English (education of Professionals in English and English for Professionals).

Research and the choice of a course of study

This paper presents some research on the choice of a course of study as related to a certain social, family and labor context. The methodology used included the definition of the theoretical basis and a series of empirical investigations which comprised different kinds of sur- veys, records, observations, participants as well as other fieldwork. The results obtained shed some light on the issue and raise new questions. This study was especially carried out to analyze the choice of the following courses of study: Law, Psychology and the different Teaching Courses.

La diversidad familiar en situaciones de exclusión social. Resultados y reflexiones sobre actividades de investigación, formación y transferencia de conocimientos

El presente artículo se propone caracterizar las configuraciones familiares que habitan en contextos de exclusión social; aportar conceptualizaciones sobre sus modos de funcionamiento a través de la sistematización de los datos recogidos y destacar los efectos formativos que las prácticas interdisciplinarias barriales con esas familias, van produciendo en los psicólogos recién graduados, a través de una tarea de transferencia del enfoque sobre la diversidad tanto en el interior de las investigaciones como a partir de las intervenciones realizadas con las familias en las tareas de incorporados al Programa de Extensión. Asimismo, nos ha interesado poder efectuar una tarea de transferencia del enfoque sobre la diversidad en la formación de los profesionales jóvenes, tanto en el interior de las investigaciones como en el de las intervenciones realizadas con familias en las tareas de extensión. Este trabajo surge de resultados y reflexiones provenientes de tres fuentes: de lo producido en el marco de una Beca de iniciación a la Investigación; de las investigaciones sobre parentalidad, que desde el año 2001 venimos realizando en la Cátedra de Psicología Evolutiva II y del trabajo interdisciplinario con familias asistidas psicológicamente en el interior del Programa de Extensión Universitaria ?Consultorios Jurídicos Gratuitos?, asentados en doce barrios suburbanos de la ciudad de La Plata (convenio entre la Facultad de Ciencias Jurídicas y Sociales y la Facultad de Psicología, U.N.L.P.) A partir de una metodología cualitativa, con participación interdisciplinaria, los resultados obtenidos han permitido por un lado arribar a la caracterización y conceptualizaciones propuestas acerca de las familias incluidas y al mismo tiempo precisar los beneficios que para la formación de estudiantes avanzados y jóvenes graduados trae aparejado el trabajo que articula actividades de investigación y extensión

Vocation in the insertion of the university student and the graduate

The work plan aims at deepening the analysis of the theoretic assumptions which support the practice in Vocational Guidance: analyzing the incidence of endogenous and exogenous factors both in the election and studying of a particular course of study and in the occupational resolution of the graduate. This analysis enables the revision and the new theoretic conceptualization which is afterwards transferred to the course, and to different groups and provincial institutions where the practice of Vocational Guidance occurs, as well as to other schools in the Northwest provinces of Argentina. Semiotic analysis, statistical elaboration and the research-action approach which, while surveying data renders a service to the milieu, provide the base for the project. Said project focuses on the following individuals: 1) freshmen, who offer us the following aspects to be considered: a) factors which either favor or hinder the insertion of the students attending the first years of the course; b) the conditions making up the learning situation in each subject, from the teaching point of view; c) the influence of institutional dimension in the insertion process; 2) graduands: the characteristics of the situation following graduation from University, those of the labor field and the different ways of gaining access to it are investigated. This analysis is carried out in the courses of study of Psychology and English (education of Professionals in English and English for Professionals).

Research and the choice of a course of study

This paper presents some research on the choice of a course of study as related to a certain social, family and labor context. The methodology used included the definition of the theoretical basis and a series of empirical investigations which comprised different kinds of sur- veys, records, observations, participants as well as other fieldwork. The results obtained shed some light on the issue and raise new questions. This study was especially carried out to analyze the choice of the following courses of study: Law, Psychology and the different Teaching Courses.

La diversidad familiar en situaciones de exclusión social. Resultados y reflexiones sobre actividades de investigación, formación y transferencia de conocimientos

El presente artículo se propone caracterizar las configuraciones familiares que habitan en contextos de exclusión social; aportar conceptualizaciones sobre sus modos de funcionamiento a través de la sistematización de los datos recogidos y destacar los efectos formativos que las prácticas interdisciplinarias barriales con esas familias, van produciendo en los psicólogos recién graduados, a través de una tarea de transferencia del enfoque sobre la diversidad tanto en el interior de las investigaciones como a partir de las intervenciones realizadas con las familias en las tareas de incorporados al Programa de Extensión. Asimismo, nos ha interesado poder efectuar una tarea de transferencia del enfoque sobre la diversidad en la formación de los profesionales jóvenes, tanto en el interior de las investigaciones como en el de las intervenciones realizadas con familias en las tareas de extensión. Este trabajo surge de resultados y reflexiones provenientes de tres fuentes: de lo producido en el marco de una Beca de iniciación a la Investigación; de las investigaciones sobre parentalidad, que desde el año 2001 venimos realizando en la Cátedra de Psicología Evolutiva II y del trabajo interdisciplinario con familias asistidas psicológicamente en el interior del Programa de Extensión Universitaria ?Consultorios Jurídicos Gratuitos?, asentados en doce barrios suburbanos de la ciudad de La Plata (convenio entre la Facultad de Ciencias Jurídicas y Sociales y la Facultad de Psicología, U.N.L.P.) A partir de una metodología cualitativa, con participación interdisciplinaria, los resultados obtenidos han permitido por un lado arribar a la caracterización y conceptualizaciones propuestas acerca de las familias incluidas y al mismo tiempo precisar los beneficios que para la formación de estudiantes avanzados y jóvenes graduados trae aparejado el trabajo que articula actividades de investigación y extensión