Dos ciclos e sistemas aos interstícios de Creixomil: entre o seu conhecimento e transformação potencial

Dissertação de mestrado integrado em Arquitectura (área de especialização em Território)

Communications with QoS in IoT&Cloud environment

Dissertação de mestrado integrado em Engenharia de Telecomunicações e Informática

Development of a subject-specific musculoskeletal shoulder model : inverse and forward dynamics applications

A prevalência de pessoas que referem dor no complexo articular do ombro, com concomitante limitação na capacidade para realizar atividades da vida diária, é elevada. Estes níveis de prevalência sobrecarregam quer os utentes, como a própria sociedade. A evidência científica atual indicia a existência de uma relação entre as alterações da articulação escápulo-torácica e as patologias associadas à articulação gleno-umeral. A capacidade de quantificar, cinemática e cineticamente, as disfunções ao nível das articulações escápulo-torácica e gleno-umeral, é algo de enorme importância, quer para a comunidade biomecânica, como para a clínica. No decorrer dos trabalhos desta tese foi desenvolvido, através do software OpenSim, um modelo tridimensional músculo-esquelético do complexo articular do ombro que inclui a representação do tórax/coluna, clavícula, omoplata, úmero, rádio, cúbito e articulações que permitem os movimentos relativos desses segmentos, assim como, 16 músculos e 4 ligamentos. Com um total de 11 graus de liberdade, incluindo um novo modelo articular escápulo-torácico, os resultados demonstram que este é capaz de reconstruir de forma precisa e rápida os movimentos escápulo-torácicos e glenoumerais, recorrendo para tal, à cinemática inversa, e à dinâmica inversa e direta. Conta ainda com um método de transformação inovador para determinar, com base nas especificidades dos sujeitos, os locais de inserção muscular. As principais motivações subjacentes ao desenvolvimento desta tese foram contribuir para o aprofundar do atual conhecimento sobre as disfunções do complexo articular do ombro e, simultaneamente, proporcionar à comunidade clínica uma ferramenta biomecânica de livre acesso com o intuito de melhor suportar as decisões clínicas e dessa forma concorrer para uma prática mais efetiva.

Síntesis, caracterización y aplicaciones específicas de metalosilicatos cristalinos micro y mesoporosos con incorporación de nanoestructuras. Synthesis, characterization and specific aplications of crystalline micro and mesoporous metallosilicates with nanostructures.

La síntesis de materiales cristalinos micro y mesoporosos con incorporación de micro/nano partículas/clusters de especies formadas con entidades propias interaccionando con las redes, como óxidos de metales, cationes de neutralización, especies metálicas, etc., pueden potencialmente ser utilizados como "materiales hospedaje" en óptica, electrónica, sensores, como materiales magnéticos, en estrategias ambientales de control de la contaminación, catálisis en general y procesos de separación. Se sintetizaran y caracterizaran por diversas técnicas fisicoquímicas, zeolitas microporosas de poro medio (ZSM) y poro grande (Y), y materiales mesoporosos (MCM-41). La aplicación de los mismos se orientara, por una parte, a procesos catalíticos tecnológicamente innovadores relacionados con los siguientes campos: a)catálisis ambiental: transformación de desechos plásticos (polietileno, polipropileno, poliestireno o mezclas de los mismos) a hidrocarburos de mayor valor agregado (gasolinas, gasoil, gases licuados de petróleo, hidrocarburos aromáticos); b)química fina: oxidación parcial de hidrocarburos aromáticos hacia la obtención de commodities, fármacos, etc. Por otra parte, se evaluaran las propiedades magnéticas (ferromagnetismo, paramagnetismo, superparamagnetismo, diamagnetismo) que algunos de estos materiales presentan, en busca de su correlación con sus propiedades catalíticas, cuando sea factible. Se estudiaran las condiciones óptimas de síntesis de los materiales, aplicando técnicas hidrotermicas o sol gel, controlando variables como temperaturas y tiempos de síntesis, pH de geles iniciales-intermedios-finales, tipo de fuentes precursoras, etc. La modificación de las matrices con Co, Cr, Mn, H, o Zn, se realizara mediante diversos tratamientos químicos (intercambio, impregnación) a partir de las sales correspondientes, con el objeto de incorporar elementos activos al estado iónico, metálico, clusters, etc.; y la influencia de distintos tratamientos térmicos (oxidantes, inertes o reductores; atmósferas dinámicas o estáticas; temperaturas). La caracterización estructural de los materiales será por: AA (cuantificación elemental de bulk); XRD (determinacion de presencia de especies oxidos o metalicas de Zn, Co, Cr, o Mn; determinacion de cristalinidad y estructura); BET (determinacion de area superficial); DSC-TG-DTA (determinacion de estabilidad de las matrices sintetizadas); FTIR de piridina (determinacion de tipo-fuerza-cantidad de sitios activos); Raman y UV-reflectancia difusa (determinacion de especies ionicas interacturando o depositadas sobre las matrices); TPR (identificacion de especies reducibles); SEM-EDAX (determinacion de tamaño de particulas de especies activas y de las matrices y cuanfiticacion superficial); Magnetómetros SQUID y de muestra vibrante (medición de magnetización y susceptibilidad magnética a temperatura ambiente con variación de campo externo aplicado, y variación de temperaturas (4 a 300 K) con campo externo fijo). En síntesis, se plantean tres grandes áreas de trabajo: No1)Síntesis y caracterización de materiales micro y mesoporosos nanoestructurados; No2) Evaluación de las propiedades catalíticas; No3) Evaluación de las propiedades magnéticas. Estos lineamientos nos permitirán generar nuevos conocimientos científicos-tecnológicos, formando recursos humanos (dos becarios posdoctorales; un becario doctoral; tres becarios alumnos de investigación; aproximadamente 15 pasantes de grado al año) aptos para emprender tales desafíos. Los conocimientos originados son constantemente trabajados en las actividades docentes de grado y posgrado que los integrantes del proyecto poseen. Finalmente serán transmitidos y puestos a consideración de pares evaluadores en presentaciones a congresos nacionales e internacionales y revistas especializadas.

Overcoming the supply inconsistencies of tidal current energy conversion devices

The adoption of a sustainable approach to meeting the energy needs of society has recently taken on a more central and urgent place in the minds of many people. There are many reasons for this including ecological, environmental and economic concerns. One particular area where a sustainable approach has become very relevant is in the production of electricity. The contribution of renewable sources to the energy mix supplying the electricity grid is nothing new, but the focus has begun to move away from the more conventional renewable sources such as wind and hydro. The necessity of exploring new and innovative sources of renewable energy is now seen as imperative as the older forms (i.e. hydro) reach the saturation point of their possible exploitation. One such innovative source of energy currently beginning to be utilised in this regard is tidal energy. The purpose of this thesis is to isolate one specific drawback to tidal energy, which could be considered a roadblock to this energy source being a major contributor to the Irish national grid. This drawback presents itself in the inconsistent nature in which a tidal device generates energy over the course of a 24 hour period. This inconsistency of supply can result in the cycling of conventional power plants in order to even out the supply, subsequently leading to additional costs. The thesis includes a review of literature relevant to the area of tidal and other marine energy sources with an emphasis on the state of the art devices currently in development or production. The research carried out included tidal data analysis and manipulation into a model of the power generating potential at specific sites. A solution is then proposed to the drawback of inconsistency of supply, which involves the positioning of various tidal generation installations at specifically selected locations around the Irish coast. The temporal shift achieved in the power supply profiles of the individual sites by locating the installations in the correct locations, successfully produced an overall power supply profile with the smoother curve and a consistent base load energy supply. Some limitations to the method employed were also outlined, and suggestions for further improvements to the method were made.

Silent voices : the recreational needs of disabled young people : an emancipatory approach

The recreational needs of young people with.disabilities in Sligo county were examined using an emancipatory approach that provided an accurate reflection on the perspectives of the disabled young people. The aim of this study included a comparison of access to and attitudes towards leisure activities as between disabled and non-disabled young people in the Sligo area. The hypothesis set out by the researcher was the expectation that findings would include a degree of disadvantage in access and participation in leisure activities for young people with disabilities vis a vis their counterparts. The way in which this was tested was by focus groups and interviews. This hypothesis was adequately proven along with an in-depth range of recommendations for improvement that were made by participants. The study’s emancipatory research methods ensured that the voice of the participants was heard regarding their recreational needs and the disabling barriers that needed to be removed.

Tourism education in Ireland : an analysis of the provision of third level tourism education in Ireland focusing on the needs of the public, private and voluntary sectors

Tourism education in Ireland has witnessed a transformation within the last four decades since CERT introduced the first fundamentals of training in the 1960’s. An analysis of the provision of tourism education in Ireland, focusing on the needs of the public, private and voluntary sectors was the main focus of this study and concentrates mainly on third level provision of tourism education within the island of Ireland. The study examines the role of tourism education in Ireland, establishing any current or emerging trends in third level tourism provision. It identifies and analyses the main stakeholders in the public, private and voluntary sectors and investigates if any requirements exist in the provision of third level education. The multi-faceted nature of the tourism industry has resulted in the provision of a diverse range of educational courses. As a result of this diversity, a question hangs over the status of tourism as a professional discipline within itself. Other issues identified through this study are the over provision of tourism courses and the current and future disparity within tourism education. The qualitative nature of the research involved questioning of major stakeholders and educators who influence tourism education provision and developing an overview of the current status of tourism education provision in Ireland identifying the present needs of each sector. Finally several strategies are suggested which may enhance third level tourism education in the future.

Validade e equivalência da versão em português do Veterans Specific Activity Questionnaire

FUNDAMENTO: O Veterans Specific Activity Questionnaire (VSAQ) tem sido utilizado para a individualização de testes ergométricos (TE) e para avaliar indiretamente a aptidão cardiorrespiratória (ACR) em estudos epidemiológicos. Apesar disso, ainda não há versão em português validada. OBJETIVO: Verificar a validade de critério da versão em português do VSAQ e examinar a equivalência de mensuração dessa versão em 95 indivíduos, sendo 8 mulheres (69 ± 7 anos), com indicação para a realização de TE. MÉTODOS: Os indivíduos realizaram teste cardiopulmonar de exercício progressivo máximo em ciclo-ergômetro. A correlação do escore do VSAQ com o MET Máximo Medido e Estimado foi comparada com os resultados de outros estudos. O Nomograma VSAQ foi calculado e seus resultados comparados com os valores reais da ACR por regressão linear. Limites de concordância e as diferenças médias (vieses) foram avaliados segundo a metodologia proposta por Bland e Altman. RESULTADOS: Os escores obtidos através do VSAQ correlacionaram-se de forma significativa com o MET máximo medido (r = 0,64) e estimado (r = 0,67), resultados equivalentes àqueles obtidos com versões originais. O nomograma VSAQ obteve resultados com R múltiplo de 0,78 (para MET medido) e 0,80 (para MET estimado). O nomograma, entretanto, parece subestimar os valores de indivíduos com ACR acima de 6 MET. CONCLUSÃO: A versão do VSAQ confirmou-se válida e equivalente à versão original, especialmente para avaliação de indivíduos cardiopatas e de idade avançada.

Approved Drug Products with Theurapeutic Equivalence Evaluation - 34th edition

The publication, Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book), identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act). Drugs on the market approved only on the basis of safety (covered by the ongoing Drug Efficacy Study Implementation [DESI] review [e.g., Donnatal® Tablets and Librax® Capsules] or pre-1938 drugs [e.g., Phenobarbital Tablets]) are not included in this publication. The main criterion for the inclusion of any product is that the product is the subject of an application with an effective approval that has not been withdrawn for safety or efficacy reasons. Inclusion of products on the List is independent of any current regulatory action through administrative or judicial means against a drug product. In addition, the List contains therapeutic equivalence evaluations for approved multisource prescription drug products. These evaluations have been prepared to serve as public information and advice to state health agencies, prescribers, and pharmacists to promote public education in the area of drug product selection and to foster containment of health care costs. Therapeutic equivalence evaluations in this publication are not official FDA actions affecting the legal status of products under the Act.

Interaction of the brain-specific Arf-GAP protein p42 I P 4 (centaurin α1, ADAP1) with the metalloendopeptidase nardilysin and modulation by tubulin

Magdeburg, Univ., Fak. für Naturwiss., Diss., 2012

Florula bostoniensis. A collection of plants of Boston and its vicinity, with their generic and specific characters, principal synonyms, descriptions, places of growth, and time of flowering, and occasional remarks. By Jacob Bigelow ...

2nd ed.

Biomarkers in Cardiology – Part 1 – In Heart Failure and Specific Cardiomyopathies

Cardiovascular diseases are the leading causes of mortality and morbidity in Brazil. The primary and secondary preventions of those diseases are a priority for the health system and require multiple approaches to increase their effectiveness. Biomarkers are tools used to more accurately identify high-risk individuals, to speed the diagnosis, and to aid in treatment and prognosis determination. This review aims to highlight the importance of biomarkers in clinical cardiology practice, and to raise relevant points of their use and the promises for the coming years. This document was divided into two parts, and this first one discusses the use of biomarkers in specific cardiomyopathies and heart failure.

Florula bostoniensis. A collection of plants of Boston and its environs, with their generic and specific characters, synonyms, descriptions, places of growth, and time of flowering, and occasional remarks.

1st ed.

Protease-activated receptor (PAR)-1 and PAR-2 protect rat astrocytes from apoptotic cell death via differentially regulating JNK isoform-specific release of the chemokine GRO/CINC-1 : two novel protective pathways in brain

Protease-activated receptor; c-Jun N-terminal kinase (JNK); thrombin; neuroprotection; siRNA