974 resultados para guías clínicas


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Blooms of phytoplankton can be a risk to human health and aquatic biota, so the adoption of monitoring methods of phytoplankton and mechanisms for preventing its occurrence are needed. Thus, traditional monitoring methods could be more effective if complemented by approaches using the optical properties of phytoplankton pigments by means of Remote Sensing. In order to evaluate the potential of multi-scale remote sensing for detection of the phytoplankton activity, a study area was selected in Nova Avanhandava reservoir, located in the Tiete River, SP. For this analysis, hyperspectral field data and multispectral images of low and medium spatial resolution (Modis and RapidEye) were acquired and were related to indicator limnological variables of phytoplankton behavior; chlorophyll a and phycocyanin. The results show that a specific spectral band of RapidEye system (690-730 nm) allowed detect chlorophyll a and to evaluate the phytoplankton biomass, however hyperspectral data are needed to detect the phycocyanin pigment, indicative of cyanobacteria.

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Water and soil pollution caused by the waste from the swine production causes severe environmental impacts in producing areas. An efficient alternative to reduce these impacts can be the use of high-rate anaerobic reactors. In this work, it was evaluated the effect of the swine wastewater with total suspended solids concentrations around 6.000 mg.L-1 in the anaerobic baffled reactor with three compartments. The volume of the first compartment was 210 L and of the second and third ones of 160 L. The anaerobic baffled reactor was submitted at hydraulic detention times of 56, 28 and 18 hours and to organic load rates of 5.0 to 10.1 g total COD (L.d)(-1). The highest total COD removals, of 42 to 68%, and volumetric methane productions, of 0.261 to 0.454 L CH4 (L reactor d)(-1), occurred in the second compartment.

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The long-term effects of five different treatments of diabetes were evaluated in alloxan-induced diabetic rats. Seven experimental groups, with 50 rats each (GN--normal control; GD--untreated diabetic control; GI, GA, GIA--treated groups with insulin, acarbose, and insulin plus acarbose, respectively; GTIL, GTPD--treated groups with islet of Langerhans and pancreas transplantation) were studied. Clinical (body weight, water intake, food intake and urine output) and laboratory (blood and urinary glucose, and plasma insulin) parameters were analyzed at the beginning of the study, and after 1, 3, 6, 9 and 12 months of follow-up. Mortality was observed in all groups, except GN, during 12 months (GD = 50%; GI = 20%; GA = 26%; GIA = 18%; GTIL = 4%; GTPD = 20%). Rats from the GD, GI, and GIA groups died due to metabolic or hydrossaline disbalance, and/or pneumonia, diarrhoea, and cachexy. All deaths observed in GTIL and GTPD groups were in decorrence of technical failure at the immediate postoperative, until 72h. Animals from the GI, GA and GIA had significative improving of the clinical and laboratory parameters (p < 0,05) observed in diabetic rats, being the efficacy of theses treatments equal. However, rats from the GTIL and GTPD groups had better control of these parameters than GI, GA, and GIA groups. Transplanted rats had complete restoration, at the normal levels, of all analyzed variables (p < 0.01). Conventional treatments with insulin, acarbose, and insulin plus acarbose improved the severe diabetic state of the alloxan-diabetic rats, but pancreas and islet transplantation have a better performance for treatment of diabetes.

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Purpose: To compare clinical and laboratory characteristics, obstetric and perinatal outcomes of patients with pre-eclampsia versus gestational hypertension. Methods: A retrospective study was carried out to analyze medical records of patients diagnosed with pre-eclampsia and gestational hypertension whose pregnancies were resolved within a period of 5 years, for a total of 419 cases. We collected clinical and laboratory data, obstetric and perinatal outcomes. Comparisons between groups were performed using the test suitable for the variable analyzed: unpaired t test, Mann-Whitney U test or χ2test, with the level of significance set at p<0.05. Results: Were evaluated 199 patients in the gestational hypertension group (GH) and 220 patients in the pre-eclampsia group (PE). Mean body mass index was 34.6 kg/m2 in the GH group and 32.7 kg/m2 in the PE group, with a significant difference between groups. The PE group showed higher systolic and diastolic blood pressure and higher rates of abnormal values in the laboratory tests, although the mean values were within the normal range. Cesarean section was performed in 59.1% of cases of PE and in 47.5% of the GH group; and perinatal outcomes in terms of gestational age and birth weight were significantly lower in the PE group. Conclusion: Women with gestational hypertension exhibit epidemiological characteristics of patients at risk for chronic diseases. Patients with pre-eclampsia present clinical and laboratory parameters of greater severity, higher rates of cesarean delivery and worse maternal and perinatal outcomes.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Patologia - FMB

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Pós-graduação em Saúde Coletiva - FMB

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Pós-graduação em Economia - FCLAR

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OBJETIVOS: Este estudo visa a analisar os efeitos, a longo prazo, de cinco diferentes tratamentos sobre o controle metabólico de ratos diabéticos aloxânicos. MÉTODOS: Foram analisados 7 grupos experimentais, com 50 ratos cada um, sendo: GN o grupo controle normal; GD o grupo controle diabético, sem tratamento; GI, GA e GIA os grupos tratados, respectivamente, com insulina, acarbose e associação insulina + acarbose; GTIL o grupo tratado com transplante de ilhotas de Langerhans; e o GTPD o grupo tratado com transplante pancreatoduodenal heterotópico. Parâmetros clínicos (peso, ingestão hídrica, ingestão alimentar e diurese) e laboratoriais (glicemia, glicose urinária e insulina plasmática) foram avaliados em todos os animais, no início do experimento, e após 1, 3, 6, 9 e 12 meses de seguimento. RESULTADOS: À exceção do GN, mortalidade foi observada em todos os grupos experimentais no seguimento de 12 meses (GD= 50%; GI= 20%; GA= 26%; GIA= 18%; GTIL= 4%; GTPD= 20%). em GD, GI, GA e GIA os óbitos ocorreram por distúrbios metabólicos ou hidroeletrolíticos e/ou pneumonia, diarréia e caquexia; em GTIL e GTPD todos os óbitos ocorreram por falhas técnicas no pós-operatório até 72h. Animais dos grupos GI, GA e GIA tiveram melhora significativa (p < 0,05) de todos os parâmetros clínicos e laboratoriais observados em ratos diabéticos, sem diferença de efetividade entre os tratamentos. Porém, os resultados observados nestes grupos, biologicamente não foram comparáveis aos observados em GTIL e GTPD, onde observou-se correção completa, aos níveis normais, de todas as variáveis analisadas (p<0,01). CONCLUSÕES: Os tratamentos convencionais com insulina, acarbose e insulina + acarbose melhoraram o estado diabético grave dos ratos tratados, contudo, a eficácia dos tratamentos foi significativamente inferior à oferecida pelo GTIL e GTPD.

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Introduction: The fluoridation surveillance in the public water supply came up with the need to develop mechanisms that would help society in the control of water quality. To perform reliable analysis, variables such as depth of the wells and pluvial variations should be subject of research and study. Objectives: To analyze the fluoride levels of deep wells in periods of rain and drought, corresponding to four brazilian cities and compare the results. Methodology: It was made the mapping of the water supply network and the identification of the sampling points according to the number of deep wells in each locality, selecting those who had the natural fluoride level. Three points were defined for each source of water supply, and the addresses were randomly selected. The samples were analyzed in duplicate at the laboratory of the Center for Research in Public Health of the Dentistry School of Araçatuba – UNESP, during 8 months, in periods of rain and drought (total absence of rain). Results: 174 analysis were conducted, the mean fluoride levels for rain and drought times were, respectively: 0,71 and 0,73. It was used the Student’s t test (p <0.05). Conclusion: There wasn’t statistically significant differences for the periods of rain and drought in any of the cities, at the year of 2010. This study highlights the importance of health surveillance, because beyond of ensuring social control, there is also the search for investigating variables that may have directly and / or indirectly influence on the results of the analysis.

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Maintaining the levels of fluoride ion in public water supply within the parameters of adequacy it becomes essential so the measure carries a greater impact on caries prevention and control, without increasing the prevalence of dental fluorosis. Thus, it is necessary a rigorous control of the process, avoiding the undesired effects at levels above recommended levels, as well as avoiding levels below the recommended that do not offer the highest benefit. The aim of this study was to analyze the content of fluoride in public water supply in the city of Birigui, SP, with different sources of supply, checking if the fluoride levels are within the recommended. The samples were collected monthly from points previously established, with the knowledge of the distribution network of water and identifying the amount and location of supply sources and water treatment plant. Analyses were performed in duplicate in the period from January to December of 2009, in the laboratory - NEPESCO - of the Dental School of Araçatuba, Univ Estadual Paulista – UNESP, using an ion analyzer coupled to a specific electrode for fluoride. Of the total samples (n = 512), 44% (n = 224) had adequate levels and 56% (n = 288) inadequate levels, 10% (n = 49) lower levels and 46% (n = 239) showed levels above the recommended. There were differences in results when comparing the analysis of different sources. The fluoride concentration in the majority of the samples from deep wells was classified as inadequate not offering the desired benefit, or exposing the population to the risk of dental fluorosis.