Lottery Action Newsletter May 2-15, 2011, vol. 18, no. 10

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter, April 4-17, 2011, Vol. 18, no. 8

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter, March 7-20, 2011 Vol. 18, no.6

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter, Special Edition, February 14, 2011

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter, February 7-20, 2011, Vol. 18, no. 3

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter, January 3-23, 2011 Vol. 17, no. 1

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter, November 15-28, 2010 vol. 17, no. 21

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter, October 25-November 14, 2010 Vol. 17, no. 20

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter September 27-October 20, 2010, Vol. 17, no. 18

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter for July 26-August 8, 2010 Vol. 17, no.11

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter Special Edition, June 28, 2010

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter, February 22-March 7, 2010, Vol. 17, #14

Lottery Newsletter for Lottery Retailers

Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex.

We have developed a technetium labeling technology based on a new organometallic chemistry, which involves simple mixing of the novel reagent, a 99m Tc(I)-carbonyl compound, with a His-tagged recombinant protein. This method obviates the labeling of unpaired engineered cysteines, which frequently create problems in large-scale expression and storage of disulfide-containing proteins. In this study, we labeled antibody single-chain Fv fragments to high specific activities (90 mCi/mg), and the label was very stable to serum and all other challenges tested. The pharmacokinetic characteristics were indistinguishable from iodinated scFv fragments, and thus scFV fragments labeled by the new method will be suitable for biodistribution studies. This novel labeling method should be applicable not only to diagnostic imaging with 99mTc, but also to radioimmunotherapy approaches with 186/188 Re, and its use can be easily extended to almost any recombinant protein or synthetic peptide.

A step beyond--the relevance of depressed mood and mastery in the interplay between the number of social roles and alcohol use.

OBJECTIVES: The present study examines whether depressed mood and external control mediate or moderate the relationship between the number of social roles and alcohol use. PARTICIPANTS: The analysis was based on a national representative sample of 25- to 45-year-old male and female drinkers in Switzerland. METHOD: The influence of depressed mood and external control on the relationship between the number of social roles (parenthood, partnership, employment) and alcohol use was examined in linear structural equation models (mediation) and in multiple regressions (moderation) stratified by gender. All analyses were adjusted for age and education level. RESULTS: Holding more roles was associated with lower alcohol use, lower external control and lower depressed mood. The study did not find evidence of depressed mood or external control mediating the social roles-alcohol relationship. A moderation effect was identified among women only, whereby a protective effect of having more roles could not be found among those who scored high on external control. In general, a stronger link was observed between roles and alcohol use, while depressed mood and external control acted independently on drinking. With the exception of women with high external control, the study found no link between a higher number of social roles and greater alcohol use. CONCLUSION: Our results indicate that drinking behaviours are more strongly linked to external control and depressed mood than they are to the number of social roles. The study also demonstrates that in any effective alcohol prevention policy, societal actions that enable individuals to combine more social roles play a central role.