Avaliação da citotoxicidade, genotoxicidade e mutagenicidade de lentes de contato à base de celulose bacteriana com adição de complexos fármacos-ciclodextrinas

Nos últimos anos, a biotecnologia tem proporcionado avanços no desenvolvimento de biomateriais a serem utilizados como dispositivos médicos. Dentre esses dispositivos, podemos destacar aqueles que promovem a reparação tecidual e, também, a liberação controlada de fármacos. Partindo deste propósito, lentes de contato à base de celulose bacteriana (CB) foram desenvolvidas, visando o efeito curativo e reparativo para doenças da superfície ocular. A adição de ciclodextrinas (CDs) e fármacos, como o ciprofloxacino (CP) e o diclofenaco de sódio (DS) á essas lentes proporcionando propriedades terapêuticas e de liberação controlada dos fármacos. No entanto, para certificar-se do uso seguro desses compósitos pela indústria de dispositivos médicos, é necessário verificar se não possuem atividade citotóxica, genotóxica e/ou mutagênica. Sendo assim, a proposta do presente trabalho foi o desenvolvimento de uma adição eficaz de fármacos às lentes de contato de CB, para que sejam liberados de maneira controlada e, também, a verificação de sua biossegurança. Para essa verificação foram realizados ensaios in vitro de citotoxicidade (ensaio com o kit XTT e Sobrevivência Clonogênica), genotoxicidade (ensaio Cometa) e mutagenicidade (teste do Micronúcleo) com os respectivos. Após a análise estatística dos resultados foi possível verificar que o material CB-CP apresentou efeito citotóxico e os materiais CB-DS e CB-CD-DS apresentaram efeito citotóxico, genotóxico e mutagênico. Essa informação é fundamental para uma futura utilização segura desse biomaterial pela indústria de dispositivos médicos ...

Projeto de um dispositivo para prensar bobinas polares de pólos salientes para hidrogeradores

The increasing demand for productivity and quality in companies has converged to a common point: reducing costs. In this context the present work aims at the development of a mechanical press which is designed for pressing polar hydrogenerators coils with salient pole in field facilitating the assembly of the poles in the plant, as well as reforms especially in hydrogenerators, reducing significantly the transport costs. With security in mind as well as reduced costs, a study was made of the materials to be used as it was applied a methodology for calculating the correct choice of safety factor to be used in the device. Through mechanical calculations were dimensioned critical items of the device as the diameter of the rods as well as the minimum thickness of the base of the device must have so that it does not break threaded shear in the region by applying the total load of traction on the risers implementation of the pressing. All compression loading device will be through the application of torque on the nuts of bolts in this way was defined by calculations the required torque for each nut so that you can reach the pressure specified in the design specifies. The modeling of the device was made using the INVENTOR™ program in conjunction with the program ANSYS ™. These programs have created designs in three dimensions, assembly and simulation of stress analysis in components of the device

Projeto de Escola Infantil Sustentável em Bauru

The inclusion of sustainability practices in the construction is a growing trend. This propensity to sustainability takes place from the 1980’s due to the concern about the scarcity of natural resources and damages caused by the men to the environment. Another upward sector in the architecture business is the environmental psychology. The understanding of the environment and it’s planning and adaptation to meet the real user’s needs are essential factors to build an widely used and comfortable environment. An environment can only be considered complete when it meets the real user’s needs. Sustainability related themes as well as environmental psychology are highlighted in the discussions about the projects as fundamental factors to the environment’s quality. This work seeks the development of an kindergarten school, conceptually grounded in researches and analysis of school environments, playful projects and sustainability in the built environment, aiming its use in the city of Bauru. The project will be built from the understanding of the human behavior and in search of an sustainable architecture

As Relações Públicas em contextos de internacionalização organizacional: um estudo de caso sobre a aquisição da Tilibra

The objective of this study is to demonstrate how Public Relations can deal with the issue of culture clash between companies undergoing mergers and acquisitions. Within this environment of organizational change, there is the question of human and social as well as the importance of the relationship with all the publics. The Public Relations professional should be part of the organization systems to inform and promote a culture present, and participated in the climates changes and its consequences within these environments

A arte do teatro na educação durante a infância: a percepção dos professores acerca de suas contribuições

Seeking new ways to be used in the process of teaching and learning, he turned a look at alternative lines of research, going to value the arts in education, and inside, there has been a major focus of the relationship to both the theater and education. Currently, the theater has been the subject of research in education and has been also widely used as an educational resource, and its adoption by professionals is based on studies showing the contributions of the theater to child development. The theater, while playing, artistic expression and involves imagination, creation and sociability.This paper presents child development in all its phases, the importance of games, especially the symbolic games, during this process, through the perspective of Jean Piaget, a brief history of the theater within the education and the contributions actuallyits use as methodology of teaching and learning brings to children's development of the early years of elementary school, bringing the discussion as teachers' perception about the real possibility of its use in schools as a way of teaching and learning. This research aimed to understand the dialogic relationship between theater and basic education, emphasizing its most striking features, emphasize its presence in the teaching and learning in basic education, focusing on the early years of primary education; see how the skills developed with drama can help develop cognitive, psychological, social and moral development of children, performing an initial survey on the possibilities of using the theater within the lesson plans for teachers in the first grade of elementary school and learn the opinions of professional education on theresearch subject, being held with four teachers who teach in the first years of elementary education at a public school in Santa Cruz do Rio Pardo, ...(Complete abstract click electronic address below)

A formação do professor no século XXI e a educação inclusiva

This paper describes the history of Inclusive Education in Brazil, especially the inclusion of studentes with hearing disabilities im mathematics classes in regular schools. Shows the difficulties faced by these students in the teaching and learning based on inclusive education researchers, we propose some changes in behavior to meet the hearing impaired. The importance of the teaching profession, the teacher and the school culture, as well as the political-pedagogical project are also subjects of this work. With this work, we see the development of Inclusive Education in our country and how we can help you advance further

Modelo de flexibilidade de manufatura em processos de submontagem

Through observation of production process of a Vale do Paraiba’s automobile industry, one can encounter in need of improvement related to large uncertainties and variations in the production environment, a fact that inspired the search for solutions that can respond quickly to these changes. This way, the paper describes the development of a flexible manufacturing model, which aims to optimize the process in an automotive sub-assembly industry of the Paraíba Valley. The main objective is to propose a method to promote viable alternatives to easing the assembly of parallel sub performed the assembly of cars. For the construction of the model was necessary to explore concepts of flexible manufacturing and making the data presented in literature, which were vital to ensure the development of the method. The concepts discussed are usually presented at an undergraduate degree in Engineering. Data compiled by the model are able to serve as a strategic benchmark for decision making by managers. Featuring alternative response variables and uncertainties of the organizational environment, a fact that facilitates the management of human resources and productive

Um Modelo Espacial para a Resposta Imunológica Adaptativa da Hepatite B

This paper proposed a two-dimensional spatial model to describe the adaptive immune response for viral hepatitis B. This model considered six populations: healthy hepatocytes T, infected hepatocytes Y , hepatitis B virus V , innate immune system I, active immune system X and memory cells, X. First, a compartmental model was constructed and its equilibrium solutions and also the threshold values related to the stability of each solution were obtained. Using this model, we was able to reproduce the different trends observed for the disease, which are: individuals that eliminate the infection without forming immune response, patients with acute and chronic carriers. By including dispersion of defense cells of the immune system and virus (spatial model), we analyze two situations: homogeneous model, in which the model parameters are the same at all points of the network, and heterogeneous model, which characterizes cells more permeable and less permeable to virus invasion. For the two spatial models (homogeneous and heterogeneous) the times relatead to the viral erradication and/or virus invasion and persistence becoming smaller in relation to the compartmental model. The results also showed that for the set of values used in the simulations and if the two diffusion rates are different from zero, the model is sensitive to variations in the rate of viral spread and not dependent on the dispersion of memory cells. Finally, the heterogeneous model when compared to the homogeneous model shows that the infection can be spatially limited depending on the type of the cell involved in the infection process

Instalações para o Curso de Arquitetura e Urbanismo da FCT/UNESP

A necessidade de se ter profissionais capacitados para pensar a questão urbana e propor soluções inovadoras é o ponto de partida para a criação do curso de Arquitetura e Urbanismo na Faculdade de Ciências e Tecnologia da Universidade Estadual Paulista “Júlio de Mesquita Filho”. Quando da sua criação, toda a estruturação foi baseada na infraestrutura já existente no campus para que posteriormente novas instalações, adequadas às especificidades do curso, fossem pleiteadas. Com apenas oito anos de funcionamento, alunos e professores enfrentam dificuldades no desenvolvimento das atividades em função da falta de infraestrutura adequada. Dessa forma, o presente trabalho é dedicado ao desenvolvimento de um projeto que atenda de forma satisfatória as demandas existentes no curso. A partir da elaboração de estudos de projetos análogos e de analises das necessidades do campus e suas necessidades obtém‐se as diretrizes que encaminham para a escolha da uma área apropriada para implantação nesta unidade universitária e pautam o desenvolvimento do projeto, que busca inserir‐se de forma adequada ao contexto préexistente

Jogo baseado em simulação de vida artificial

The market of digital games have grown in the last years, becoming popular between many ages, the number of smartphones and tablets users have also showed a recent increase, including the ones using Android as operational system. The main objective of a digital game is the ludic activity but also it can be used as a tool to education, learning and even simulation. This work proposes the development of a game for smartphones or tablet running on Android operational system, this game will simulate living beings in an environment, each one with different behaviors, based in the concepts of artificial live, cellular automata and emergence. This way simulating the behavior of a living being community with a computational base in artificial live and following concepts of game design. The game can represent visually some characteristics of living beings, as well behaviors and interactions between them, in a very simple way. The game can be upgraded in the future to represent better living beings using more details to the simulation of these

Utilização da instrumentação virtual em Labview para criação da interface gráfica do amplificador lock-in utilizado em estudos fisiológicos a partir da comunicação via porta serial

This work presents the development of a graphical interface to the Lock-in Amplifier, which is used in physiological studies on the motility of the gastrointestinal tract in rats and signal processing. With a simple and low cost instrumentation, the resources offered by the virtual interface of LabVIEW software allows the creation of commands similar to the actual instrument that, through communication via standard serial port, transmits data between a PC and peripheral device performing specific and particular needs in the amplifier. Created for the lock-in amplifier model SR830 Stanford Research Systems, the remote manipulation gives the user greater accessibility in the process of configuration and calibration. And, since the software is installed, there is the advantage of eliminating the need of purchase new devices to upgrade the system. The commands created were made to perform six basic modifications that are used in routine of the Biomagnetism Laboratory. The instrumentation developed has the following controls: Amplitude, Frequency, Time Constant, slope low pass filter, sensitivity and offset

Classificação de workflows baseados em web services

Over the last decades changes have occurred in communication within and between enterprises, made easier by technologies suchas E-commerce, Internet, ERP systems and remote meetings and there was a rapid progress in network technology, which has changed the way business is done. A standardized way to offer services over the internet is using web services. Web services are a kind of remote procedure call and are generally used to integrate systems, independent of language, both client and server. It is common to use several web services run in sequence to perform a business process. To this type of process, gives the name of workflow. Thus, Web services are the primary components of workflows. A tool that provides a way of visualizing the behavior of a workflow can assist the administrator and is required. The present work presents the development of a tool that allows the administrator to classify visually services components and evaluate their importance in the final performance of a workflow. As proof of concept we used several virtual servers and computers where each computer has received a set of web services. A proxy was added between each call of workflows collecting relevant information and storing them in a database for later analysis. The analysis was based on Quality of Service parameters

Poética e Figuratividade: uma análise de Io (Ovídio, Metamorfoses, I, 583-747)

This paper presents the development of a scientific investigation that addresses the Latin text using theoretical concepts of Linguistic, Literary Poetic and Semiotic in order to focus mainly on aspects of the figurative expression. Therefore, the meaning effects raised by the perception through the reading of text were taken as baseline data to investigate the particular arrangement of language, responsible for expression of these effects. As a result of this investigation, a metalinguistic discourse was produced about the basic features of the poetic figurativity of the text. This analysis and description had a focus mainly on the first step of the procedures of figurativization, i.e., the figuration of the discourse, when a theme is coated by semiotic figures. In addition, reference notes were drafted to accompany the selected translation of support, with general comments about the culture (mythology, history, geography, philosophy, etc.), necessary data to an more comprehensive understanding of the text (these notes shall provide basic subsidies for reading the original Latin)

Sistema de automação residencial controlado via rede doméstica

The present work develops a residential automation system controlled by PIC microcontroller connected to a domestic network using the TCP/IP protocol. This was motivated by the viability of building an automation system to control basic elements of a house with low cost, which cannot be found nowadays. Initially is presented a brief history of the automation systems and an introduction about PIC microcontrollers. Afterwards is presented an overview of the system to be implemented. Then it is shown a suggested circuit and the sensor and actuator elements as well as the software to manage the system, this was all build and test in the laboratory. In the end are the results obtained from the prototype, like the energy consumption, the cost, efficiency and reliability

Controle fuzzy de um motor dc utilizando sistema de aquisição de dados e o matlab

The present work develops a fuzzy inference system to control the rotation speed of a DC motor available in Degem Kit. Therefore, it should use the fuzzy toolbox of Matlab in conjunction with the data acquisition board NI - USB - 6009, a National Instrument’s board. An introduction to fuzzy logic, the mathematical model of a DC motor and the operation of data acquisition board is presented first. Followed by the controller fuzzy model implemented using Simulink which is described in detail. Finally, the prototype is shown and the simulator results are presented