Cytotoxic action of Brazilian propolis in vitro on canine osteosarcoma cells

Osteosarcoma (OSA) is a primary bone neoplasm frequently diagnosed in dogs. The biology of OSA in pet dogs is identical to that of pediatric patients, and it has been considered an excellent model in vivo to study human OSA. Since the individual response to chemotherapy is unpredictable and considering that propolis is a natural product with several biological properties, this work evaluated the cytotoxic action of propolis on canine OSA cells. The primary cell culture of canine OSA was obtained from the tumor of a dog with OSA. Cell viability was assessed after incubation with propolis, 70% ethanol (propolis solvent), and carboplatin after 6, 24, 48, and 72 h. Cell viability was analyzed by the crystal violet method. Data showed that canine OSA cells were sensitive to propolis in a dose- and time-dependent manner and had a distinct morphology compared to control. Its solvent (70% ethanol) had no effect on cell viability, suggesting that the cytotoxic action was exclusively due to propolis. Our propolis sample exerted a cytotoxic effect on canine OSA cells, and its introduction as a possible therapeutic agent in vivo could be investigated, providing a new contribution to OSA treatment. Copyright © 2012 John Wiley & Sons, Ltd.

Study of the threshold line between macroscopic and bulk behaviors for homogeneous type II superconductors

In this work we solved the time dependent Ginzburg-Landau equations to simulate homogeneous superconducting samples with square geometry for several lateral sizes. As a result of such simulations we notice that in the Meissner state, when the vortices do not penetrate the superconductor, the response of small samples are not coincident with that expected for the bulk ones, i.e., 4. πM=. -. H. Thus, we focused our analyzes on the way which the M(. H) curves approximate from the characteristic curve of bulk superconductors. With such study, we built a diagram of the size of the sample as a function of the temperature which indicates a threshold line between macroscopic and bulk behaviors. © 2013 Elsevier B.V.

Stability and collapse of fermions in a binary dipolar boson-fermion 164Dy-161Dy mixture

We suggest a time-dependent mean-field hydrodynamic model for a binary dipolar boson-fermion mixture to study the stability and collapse of fermions in the 164Dy-161Dy mixture. The condition of stability of the dipolar mixture is illustrated in terms of phase diagrams. A collapse is induced in a disk-shaped stable binary mixture by jumping the interspecies contact interaction from repulsive to attractive by the Feshbach resonance technique. The subsequent dynamics is studied by solving the time-dependent mean-field model including three-body loss due to molecule formation in boson-fermion and boson-boson channels. Collapse and fragmentation in the fermions after subsequent explosions are illustrated. The anisotropic dipolar interaction leads to anisotropic fermionic density distribution during collapse. This study is carried out in three-dimensional space using realistic values of dipolar and contact interactions. © 2013 American Physical Society.

Remodelação cardíaca induzida plea deficiência de vitamina D em ratos. -

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Participação do gene Alc11a1 na infecção por Paracoccidioides brasiliensis em linhagens de camundongos selecionados segundo a alta ou baixa reatividade inflamatória aguda

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo multi-instrumental do processo de desintegração de comprimidos envolvendo três classes de desintegrantes

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Investigando o efeito de campos elétrico e magnético em um sistema dissipativo pulsante

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Transições de fase nas dinâmicas de uma partícula se movendo em um poço ou barreira de potencial dependentes periodicamente do tempo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Propriedades de tranporte, caos e dissipação num sistema dinâmico não linear

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Conseqüencias do arrasto viscoso no modelo Fermi-Ulam

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Aceleração de Fermi em bilhares com fronteiras dependentes do tempo descritas por osciladores não lineares: caso conservativo e dissipativo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Dissipação via arrasto viscoso como mecanismo de supressão da aceleração de Fermi no bilhar elíptico-ovoide com fronteira dependente do tempo

Pós-graduação em Física - IGCE

Avaliação do cloridrato de tetraciclina na remoção da smear layer radicular, em diferentes concentrações, tempos e modos de aplicação. Análise através de microscopia eletrônica de varredura

Pós-graduação em Odontologia - FOAR

Caracterização de nanoestruturas de óxido de estanho como sensores de gás

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Dinâmica de vórtices em filmes finos supercondutores de superfície variável

Pós-graduação em Ciência e Tecnologia de Materiais - FC