Predicting the Pose of β-Casomorphin-5 and 7 in the Opioid Receptors

The opioid receptors consist of three main subtypes; μ, δ, and κ. Previous binding studies have shown that fragments of the milk protein, β-casein, known as β-casomorphins are agonists of these receptors which are selective for the μ receptor subtype. Using the crystal structures of these three receptors, computational molecular docking studies were done using the software GOLD to determine the conformation of β-casomorphin-5 and 7 when they bind to these three opioid receptors. GOLD was able to discriminate among the three receptors when docking the rigid ligands co-crystalized with the receptors. However, GOLD could not discriminate among the three receptors for either of the highly flexible β-casomorphins. A per amino acid scoring method was developed to overcome this problem. This method was used to predict the conformation of both β-casomorphin-5 and 7 in the μ receptor and determine that the two amino acid residues, Lys303 and Trp318 of the μ receptor are responsible for discriminating among the three receptor subtypes for binding of the β-casomorphin-5 and 7.

Chute Losses Aren't Accidents! Most Injuries can be Avoided. Here's How to Rate the Performance of Your Chute and Crew

The conclusion of the article reads "good handling during processing and re-implanting could mean the difference between a going operation and financial disaster. But it's up to you to make certain your crew understands and follows proper chute practices. When they do, it will mean more money in your pocket."

The Influence of Motivational Behaviours and Goal Profiles on Positive Youth Development

Positive Youth Development (PYD) research has started to shift focus onto how different internal factors such as temperament, dispositions, and/or personality characteristics could influence levels of PYD for youth participating is organized sport. The purpose of this study is to examine how different goal profiles, specifically categorized by diverse levels of task and ego orientation, can influence levels of PYD in an organized youth sport setting. One hundred youth sport participants (mean age = 16.8) completed the short form Youth Experiences Survey for Sport (short form YES-S; Sullivan et al., 2013) to measure PYD, as well as the Task and Ego Orientation in Sport Questionnaire (TEOSQ; Duba 1989) to assess each athlete’s goal profile. A TwoStep Cluster Analysis was used to classify each individual’s personal goal profile into 3 statistically different cluster groupings. Results indicated significant interaction between the PYD outcome factor of Initiative vs. Clusters [F(2,95)= 10.86, p < 0.001, p2= 0.19] as well as Goal Setting vs. Clusters [F(2,95)= 3.95, p < 0.05, p2= 0.08]. Post-hoc analyses provided results that suggest that those athletes who are more task oriented have fostered more positive outcomes from sport, therefore having more goal setting skills and initiative.

Indenture between St. Catharines Cemetery of the Corporation of the City of St. Catharines and Samuel D. Woodruff

Indenture between St. Catharines Cemetery of the Corporation of the City of St. Catharines and Samuel D. Woodruff, cemetery deed no. 1253, May 18, 1883.

Indenture between Victoria Lawn Cemetery of the Corporation of the City of St. Catharines and Samuel D. Woodruff

Indenture between Victoria Lawn Cemetery of the Corporation of the City of St. Catharines and Samuel D. Woodruff for 112 sq.ft. known as part of section P. This is deed no. 1905, Oct. 21, 1901.

Indenture between Victoria Lawn Cemetery of the Corporation of the City of St. Catharines and Hamilton K. Woodruff

Indenture between Victoria Lawn Cemetery of the Corporation of the City of St. Catharines and Hamilton K. Woodruff for 216 square feet, Lot no.2 in division 9, section G of the Victoria Lawn Cemetery. This is a handwritten copy. The deed no. is 1937, Jan. 6, 1903.

Statement signed by Hume Blake who has read the will of Joseph Clement and the will of Mary M. Clement

Statement signed by Hume Blake of Toronto (2 ½ pages) who has read the will of Joseph Clement dated May 14, 1810 and has also read the will of Mary M. Clement dated Sept. 10, 1842. He states that the devise to James D. Clement and Joseph Clement is void. “The executor therefore take the personal estate … and the lands devised to James and Joseph Clement descend unencumbered to the heir of the testator Joseph Clement.” This document is slightly burned on the edges but text is not affected. The outer page says “Mr. Hume Blake for Brock Woodruff, May 9, 1845.

Letter from Gordon Pringle Dallas of Edinburgh inquiring about the reputation of Jarvis, Conklin and Co.

Letter from Gordon Pringle Dallas of Edinburgh inquiring about the reputation of Jarvis, Conklin and Co. The letter is addressed to S.D. Woodruff, Sept. 4, 1884.

Clipping from a Town Council meeting at which estimates of the costs of Railway Line no. 1 and Line no. 2 were submitted by the office of Port Dalhousie and Thorold Railway

Clipping from a Town Council meeting at which estimates of the costs of Railway Line no. 1 and Line no. 2 were submitted by the office of Port Dalhousie and Thorold Railway. The estimate was submitted by S.D. Woodruff and George Rykert, president. There is also a disclaimer in which Calvin Phelps claims to have resigned as director of the Port Dalhousie and Thorold Railway when he discovered that the company had no intention to adhere to the original plan for building and running the road, Aug. 1854.

List of instruments which are the property of Port Dalhousie and Thorold Railway in the possession of F. Laler

List of instruments which are the property of Port Dalhousie and Thorold Railway in the possession of F. Laler. This document is signed by S.D. Woodruff, Dec. 4, 1856.

Port Dalhousie and the Thorold Railway pay roll for the months of October, November and December, 1854

Port Dalhousie and the Thorold Railway pay roll for services of engineering and contingencies furnished for the months of October, November and December, 1854.

Port Dalhousie and the Thorold Railway pay roll for the months of October, November and December, 1854, signed by S.D. Woodruff, Jan. 8, 1855

Port Dalhousie and the Thorold Railway pay roll for services of engineering and contingencies furnished for the months of October, November and December, 1854, signed by S.D. Woodruff, Jan. 8, 1855.

Port Dalhousie and the Thorold Railway pay roll for the months of June, July and August, 1855, signed by S.D. Woodruff. There is an envelope included with this document, Aug. 21, 1855

Port Dalhousie and the Thorold Railway pay roll for services of engineering and contingencies furnished for the months of June, July and August, 1855, signed by S.D. Woodruff. There is an envelope included with this document, Aug. 21, 1855.

Port Dalhousie and the Thorold Railway pay roll for the months of March, April and May, 1856

Port Dalhousie and the Thorold Railway pay roll for services of engineering and contingencies furnished for the months of March, April and May, 1856.

Port Dalhousie and the Thorold Railway pay roll for the months of March, April and May, 1856, signed by S.D. Woodruff, June 3, 1856

Port Dalhousie and the Thorold Railway pay roll for services of engineering and contingencies furnished for the months of March, April and May, 1856, signed by S.D. Woodruff, June 3, 1856.