Synodorum generalium ac provincialium decreta, et canones /

Mode of access: Internet.

Epistolae et vita D. Thomae martyris et Archi-episcopi Cantuariensis : nec non epistolae Alexandri III Pontificis, Galliae regis Ludovici Septimi, Angliae regis Henrici II ... : in lucem productae ex manuscripto Vaticano /

Mode of access: Internet.

Opuscula posthuma : hactemus in-edita & edita /

Mode of access: Internet.

Opusculorum ad M. Reuerendi ... F. Christiani Lupi, iprensis ... Ord. FF. Eremitar S. Augustini ... pars altera eius operum tomus duodecimus ac postremus /

Mode of access: Internet.

[Opera.]

Mode of access: Internet.

Le traditionalisme et le rationalisme examinés au point de vue de la philosophie et de la doctrine catholique /

Contiene: T. I (X, 355 p.) - T. II (606 p.) - T. III (953 p.)

Women's health beat /

Contains 32 Spanish language pamphlets which use a Q and A (Question/Answer) format to provide information on various women's health topics.

Newe deudsche geistliche Gesenge für die gemeinen Schulen.

Contains works by Martinus Agricola, Anonymous (Georg Rhaw?), Huldricus Bretel, Arnoldus de Bruck, Sixtus Dieterich, Benedictus Ducis, Georg Förster, Vergilius Hauck, Wolff Heintz, Lupus Hellingk, Stephanus Mahu, Nicolaus P. (Piltz?), Baltasar Tesinarius, Ludovicus Senffel, Johannes Stahl, Thomas Stoltzer, Georgius Vogelhuber, and Johannes Weinmann.

Ein hundert fünfzehn weltliche u. einige geistliche Lieder mit deutschem, lateinischem, französischem und italienischem Text zu vier, fünf und sechs Stimmen gesetzt von den bedeutendsten Meistern des XV. und XVI. Jahrhunderts...

Contains polyphonic vocal works by various composers, including Heinrich Isaac, Ludwig Senfl, Thomas Stoltzer, Stephan Mahu, Mathias Eckel, Wilhelm Braytengrässer, Sixt Dieterich, Arnold von Bruck, Crecquillon, Gombert, Lupus, Richafort, and Verdelot.

Opera, Stephanvs Balvzivs tutelensis in vnum collegit, epistolas ad fidem vetustissimi codicis emendauit, notisque illustrauit.

Mode of access: Internet.

Chronic graft-versus-host disease after granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation: The role of donor T-cell dose and differentiation

The use of granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood as a source of stem cells has resulted in a high incidence of severe chronic graft-versus-host disease (cGVHD), which compromises the outcome of clinical allogeneic stem cell transplantation. We have studied the effect of G-CSF on both immune complex and fibrotic cGVHD directed to major (DBA/2 --> B6D2F1) or minor (B10.D2 --> BALB/c) histocompatibility antigens. In both models, donor pretreatment with G-CSF reduced cGVHD mortality in association with type 2 differentiation. However, after escalation of the donor T-cell dose, scleroderma occurred in 90% of the recipients of grafts from G-CSF-treated donors. In contrast, only 11% of the recipients of control grafts developed scleroderma, and the severity of hepatic cGVHD was also reduced. Mixing studies confirmed that in the presence of high donor T-cell doses, the severity of scleroderma was determined by the non-T-cell fraction of grafts from G-CSF-treated donors. These data confirm that the induction of cGVHD after donor treatment with G-CSF is dependent on the transfer of large numbers of donor T cells in conjunction with a putatively expanded myeloid lineage, providing a further rationale for the limitation of cell dose in allogeneic stem cell transplantation. (C) 2004 American Society for Blood and Marrow Transplantation.

Tumour necrosis factor inhibitors

The cytokine, tumour necrosis factor-alpha (TNF-alpha) plays a key role in the pathogenesis of many chronic inflammatory and rheumatic diseases, in particular, Crohn's disease, rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Controlled trials have shown that the TNF inhibitors (etanercept, infliximab and adalimumab) significantly reduce symptoms and signs, improve function and quality of life, and reduce radiologically evident damage in patients with rheumatoid diseases. For reasons that are not entirely clear, etanercept does not work in Crohn's disease. Injection site and intravenous reactions and increased risk of infection (in particular, reactivation of tuberculosis) are associated with the use of these agents. Increased risk of lymphoproliferative disease, the development of lupus-like syndromes and demyelination, including optic neuritis and reactivation of multiple sclerosis, are under evaluation in long-term follow-up studies. The TNF inhibitors are expensive (about $18000 per year), and in some patients need to be given continuously to maintain benefit, even in the presence of other immunosuppressive therapy.

The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients

Type 1 diabetes (T1D) is a multifactorial autoimmune disease, with strong genetic component. Several susceptibility loci contribute to genetic predisposition to T1D. One of these loci have been mapped to chromosome 1q42 in UK and US joined affected family data sets but needs to be replicated in other populations. In this study, we evaluated sixteen microsatellites located on 1q42 for linkage with T1D in 97 Russian affected sibling pairs. A 2.7-cm region of suggestive linkage to T1D between markers D1S1644 and D1S225 was found by multipoint linkage analysis. The peak of linkage was shown for D1S2847 (P = 0.0005). Transmission disequilibrium test showed significant undertransmission of the 156-bp allele of D1S2847 from parents to diabetic children (28 transmissions vs. 68 nontransmissions, P = 0.043) in Russian affected families. A preferential transmission from parents to diabetic offspring was also shown for the T(-25) and T1362 alleles of the C/T(-25) and C/T1362 dimorphisms, both located at the TAF5L gene, which is situated 103 kb from D1S2847. Together with the A/C744 TAF5L SNP, these markers share common T(-25)/A744/T1362 and C(-25)/C744/T1362 haplotypes associated with higher and lower risk of diabetes (Odds Ratio = 2.15 and 0.62, respectively). Our results suggest that the TAF5L gene, encoding TAF5L-like RNA polymerase II p300/CBP associated factor (PCAF)-associated factor, could represent the susceptibility gene for T1D on chromosome 1q42 in Russian affected patients.