Zombie mouse in a Chinese Room

John Searle’s Chinese Room Argument (CRA) purports to demonstrate that syntax is not sufficient for semantics, and, hence, because computation cannot yield understanding, the computational theory of mind, which equates the mind to an information processing system based on formal computations, fails. In this paper, we use the CRA, and the debate that emerged from it, to develop a philosophical critique of recent advances in robotics and neuroscience. We describe results from a body of work that contributes to blurring the divide between biological and artificial systems; so-called animats, autonomous robots that are controlled by biological neural tissue and what may be described as remote-controlled rodents, living animals endowed with augmented abilities provided by external controllers. We argue that, even though at first sight, these chimeric systems may seem to escape the CRA, on closer analysis, they do not. We conclude by discussing the role of the body–brain dynamics in the processes that give rise to genuine understanding of the world, in line with recent proposals from enactive cognitive science.

The Rilke of Ruth Speirs: new poems, Duino Elegies, Sonnets to Orpheus & others

Rainer Maria Rilke (1875-1926) is universally recognized as among the most important twentieth-century German-language poets. Here, for the first time, are all the surviving translations of his poetry made by Ruth Speirs (1916-2000), a Latvian exile who joined the British literary community in Cairo during World War Two, becoming a close friend of Lawrence Durrell and Bernard Spencer. Though described as ‘excellent’ and ‘the best’ by J. M. Cohen on the basis of magazine and anthology appearances, copyright restrictions meant that during her lifetime, with the exception of a Cairo-published Selected Poems (1942), Speirs was never to see her work gathered between covers and in print. This volume, edited by John Pilling and Peter Robinson, brings Speirs’ translations the belated recognition they deserve. Her much-revised and considered versions are a key document in the history of Rilke’s Anglophone dissemination. Rhythmically alive and carefully faithful, they give a uniquely mid-century English accent to the poet’s extraordinary German, and continue to bear comparison with current efforts to render his tenderly taxing voice.

The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling

Parkinson's disease is characterized by the progressive and selective loss of dopaminergic neurons in the substantia nigra. It has been postulated that endogenously formed CysDA (5-S-cysteinyldopamine) and its metabolites may be, in part, responsible for this selective neuronal loss, although the mechanisms by which they contribute to such neurotoxicity are not understood. Exposure of neurons in culture to CysDA caused cell injury, apparent 12-48 h post-exposure. A portion of the neuronal death induced by CysDA was preceded by a rapid uptake and intracellular oxidation of CysDA, leading to an acute and transient activation of ERK2 (extracellular-signal-regulated kinase 2) and caspase 8. The oxidation of CysDA also induced the activation of apoptosis signal-regulating kinase 1 via its de-phosphorylation at Ser967, the phosphorylation of JNK (c-Jun N-terminal kinase) and c-Jun (Ser73) as well as the activation of p38, caspase 3, caspase 8, caspase 7 and caspase 9. Concurrently, the inhibition of complex I by the dihydrobenzothiazine DHBT-1 [7-(2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid], formed from the intracellular oxidation of CysDA, induces complex I inhibition and the subsequent release of cytochrome c which further potentiates pro-apoptotic mechanisms. Our data suggest a novel comprehensive mechanism for CysDA that may hold relevance for the selective neuronal loss observed in Parkinson's disease.

Barriers to “industrialisation” for interwar British retailing? The case of Marks & Spencer Ltd.

Research on international differences in retail productivity has highlighted formidable environmental barriers to the ‘industrialisation’ of mass retailing as a driver of declining British interwar productivity growth in this sector (and in services more generally). We examine evidence for such barriers, using a case study of a firm that built its interwar expansion strategy on ‘American’ retail methods – Marks & Spencer (M&S). We find that, rather than facing barriers to the adoption of American mass retail practices, M&S reaped major productivity gains from this process. This adds further evidence to an emerging literature rejecting the barriers to industrialisation thesis for retailing.

Skapandet av skräcken : John Ajvide Lindqvists Låt den rätte komma in

Syftet med denna uppsats är att undersöka hur och med vilka medel det skrämmande i John Ajvide Lindqvists Låt den rätte komma in skapas, hur detta förmedlas till läsaren och vilka konsekvenser detta får samt att undersöka på vilket sätt vampyren Eli skiljer sig från den traditionella vampyren.Utgångspunkt i romanen är den mänskliga kroppen och särskilt fokus läggs vid kroppsvätskor, kroppslukter, det sexuellt avvikande och den deformerade kroppen. Gestaltningen av detta handlar om ett brytande mot tabun och etablerade normer som finns i vårt samhälle i dag. Detta skapar känslor av obehag och äckel hos läsaren. Ajvide Lindqvist använder sig av det groteska i syfte att illustrera de obekvämligheter som vi inte vill kännas vid.Eli skiljer sig från den traditionella vampyren genom att vara ett barn och genom att kunna uppfattas som flicka. Här finns också en komplexitet vad gäller kön, då Eli kan sägas vara intergender – av ett odefinierbart kön som ligger bortom de vanliga kategorierna "man" och "kvinna".