School Leader Update, December 2009

Monthly newsletter produced by Iowa Department of Education

Audit report on Sheldon Community School District in Sheldon, Iowa for the year ended June 30, 2009

Audit report on Sheldon Community School District in Sheldon, Iowa for the year ended June 30, 2009

School Leader Update, January 2010

Monthly newsletter produced by Iowa Department of Education

Audit report on Dunkerton Community School District in Dunkerton, Iowa for the year ended June 30, 2009

Audit report on Dunkerton Community School District in Dunkerton, Iowa for the year ended June 30, 2009

School Leader Update, February 2010

Monthly newsletter produced by Iowa Department of Education

School Leader Update, July, 2006

Monthly newsletter produced by Iowa Department of Education

School Leader Update, August, 2006

Monthly newsletter produced by Iowa Department of Education

School Leader Update, March 2010

Monthly newsletter produced by Iowa Department of Education

Report on a special investigation of the Cedar Rapids Community School District for the period July 1, 2002 through August 24, 2009

Report on a special investigation of the Cedar Rapids Community School District for the period July 1, 2002 through August 24, 2009

School Leader Update, April 2010

Monthly newsletter produced by Iowa Department of Education

School Leader Update, May 2010

Monthly newsletter produced by Iowa Department of Education

School Leader Update, June 2010

Monthly newsletter produced by Iowa Department of Education

Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers.

While it was thought that most of cerebral creatine is of peripheral origin, AGAT and GAMT are well expressed in CNS where brain cells synthesize creatine. While the creatine transporter SLC6A8 is expressed by microcapillary endothelial cells (MCEC) at blood-brain barrier (BBB), it is absent from their surrounding astrocytes. This raised the concept that BBB has a limited permeability for peripheral creatine, and that the brain supplies a part of its creatine by endogenous synthesis. This review brings together the latest data on creatine and guanidinoacetate transport through BBB and blood-CSF barrier (BCSFB) with the clinical evidence of AGAT-, GAMT- and SLC6A8-deficient patients, in order to delineate a clearer view on the roles of BBB and BCSFB in the transport of creatine and guanidinoacetate between periphery and CNS, and on brain synthesis and transport of creatine. It shows that in physiological conditions, creatine is taken up by CNS from periphery through SLC6A8 at BBB, but in limited amounts, and that CNS also needs its own creatine synthesis. No uptake of guanidinoacetate from periphery occurs at BBB except under GAMT deficiency, but a net exit of guanidinoacetate seems to occur from CSF to blood at BCSFB, predominantly through the taurine transporter TauT.

Report on a special investigation of the Food Service Department of the Springville Community School District for the period July 1, 2005 through March 31, 2009

Report on a special investigation of the Food Service Department of the Springville Community School District for the period July 1, 2005 through March 31, 2009