Meta-analysis identifies seven susceptibility loci involved in the atopic march.

Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.

Kundmachung: Franz Xaver Sinsler, aus Friedek in k. k. Schlesien gebürtig, 38 Jahre alt ...

Welsch (Projektbearbeiter): Verurteilung des Mechanikers Sinsler zu fünfjähriger Zwangsarbeit wegen bewaffneten Aufruhrs; Erlaß der Strafe auf dem Wege der Begnadigung

Karl der Große und Kalonymos aus Lucca

J. Aronius

Wie die Frankfurter Juden Karl VII. huldigten

J. Kracauer

Cone beam computed tomography (CBCT) for diagnosis and treatment planning in periodontology: A systematic review.

OBJECTIVE The improvement in diagnostic accuracy and optimization of treatment planning in periodontology through the use of three-dimensional imaging with cone beam computed tomography (CBCT) is discussed controversially in the literature. The objective was to identify the best available external evidence for the indications of CBCT for periodontal diagnosis and treatment planning in specific clinical situations. DATA SOURCES A systematic literature search was performed for articles published by 2 March 2015 using electronic databases and hand search. Two reviewers performed the study selection, data collection, and validity assessment. PICO and PRISMA criteria were applied. From the combined search, seven studies were finally included. CONCLUSION The case series were published from the years 2009 to 2014. Five of the included publications refer to maxillary and/or mandibular molars and two to aspects related to vertical bony defects. Two studies show a high accuracy of CBCT in detecting intrabony defect morphology when compared to periapical radiographs. Particularly, in maxillary molars, CBCT provides high accuracy for detecting furcation involvement and morphology of surrounding periodontal tissues. CBCT has demonstrated advantages, when more invasive treatment approaches were considered in terms of decision making and cost benefit. Within their limits, the available data suggest that CBCT may improve diagnostic accuracy and optimize treatment planning in periodontal defects, particularly in maxillary molars with furcation involvement, and that the higher irradiation doses and cost-benefit ratio should be carefully analyzed before using CBCT for periodontal diagnosis and treatment planning.

Gesang für die Judenschaft zu Deßau : bei Gelegenheit des in der dortigen Synagoge feyerlichst begangenen siebenzigsten hohen Geburtsfestes Sr. Herzogl. Durchlaucht Herrn Leopold Friedrich Franz, den 10. August 1810

Joseph Wolf

Zur neuen Relevanz des sozialen Kontexts für das Wahlverhalten. Antwort auf die kritischen Anmerkungen von Franz Urban Pappi

Wir antworten auf die Kritik an unserem Artikel (Ackermann u. Traunmüller 2014) und argumentieren, dass Theorien über die abnehmende Bedeutung sozial-struktureller Merkmale für das Wahlverhalten fehlgeleitet sind. Stattdessen interessiert uns die gehaltvollere Frage, wie und unter welchen Bedingungen sie politisch wirksam werden. Diese Theorieperspektive öffnet den Blick für regionale und temporale Variation sozialer Einflussprozesse, welche gängigen Ansichten zum Cleavage-Voting widersprechen. Wir unterstützen unser Argument, indem wir demonstrieren, dass soziale Kontexte für das individuelle Wahlverhalten heutzutage wichtiger sind als noch vor Jahrzehnten. Abschließend diskutieren wir weiterführende Implikationen für soziale Kontextanalysen des Wahlverhaltens.

Ode an Seine Hoheit den Durchlauchtigsten und Hochwürdigsten Herrn Karl Fürst Primas : Untertänigst dargereicht von seinen treuen Untertanen jüdischer Religion zu Frankfurt am Main am 3. Aug. 1807

Schalom Jakob Cohen

Eine Vision Siona's : Seiner Hoheit des Durchlauchtigsten Fürsten Primas Karl in tiefer Ehrfurcht dargereicht

Lipmann Mose Büschenthal

Karl Emil Franzos [Rezension]

J. S.

Karl Emil Franzos [Rezension]

A. L.