Lichtheimia Infection in a Lymphoma Patient: Case Report and a Brief Review of the Available Diagnostic Tools

We describe the case of a patient with a T-lymphoblastic lymphoma whose disseminated mucormycosis was diagnosed with delay, and we address the diagnostic and therapeutic decision-making process and review the diagnostic workup of patients with potential IFD. The diagnosis was delayed despite a suggestive radiological presentation of the patient's pulmonary lesion. The uncommon risk profile (T-lymphoblastic lymphoma, short neutropenic phases) wrongly led to a low level of suspicion. The diagnosis was also hampered by the lack of indirect markers for infections caused by Mucorales, the low sensitivity of both fungal culture and panfungal PCR, and the limited availability of species-specific PCR. A high level of suspicion of IFD is needed, and aggressive diagnostic procedures should be promptly initiated even in apparently low-risk patients with uncommon presentations. The extent of the analytical workup should be decided on a case-by-case base. Diagnostic tests such as the galactomannan and β-D-glucan test and/or PCR on biological material followed by sequencing should be chosen according to their availability and after evaluation of their specificity and sensitivity. In high-risk patients, preemptive therapy with a broad-spectrum mould-active antifungal agent should be started before definitive diagnostic findings become available.

Second Central American Integration Fund loan : proposal and recommendations for the review of the Development Loan Committee /

"AID-DLC/P-560 revised."

Peru, agricultural cooperative federations development : project paper : proposal and recommendations for the review of the Development Loan Committee /

"Unclassified."

A review of the driver-vehicle effectiveness (DRIVEM) model. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Pedestrian safety programs - a review of the literature and operational experience. Final report.

Federal Highway Administration, Office of Research, Washington, D.C.

Review of the United Nations 33d Commission on Human Rights : hearing before the Subcommittee on International Organizations of the Committee on International Relations, House of Representatives, Ninety-fifth Congress, first session, May 19, 1977.

Mode of access: Internet.

Ecuador, small enterprise loan : proposal and recommendations for the review of the Development Loan Committee /

"Unclassified."

The commerce and prospects of England, and a review of the agricultural, iron, and cotton trades.

Mode of access: Internet.

Alcohol and highway safety 1978: a review of the state of knowledge (summary volume).

Mode of access: Internet.

IVHS Institutional and Legal Issues Program. Review of the Travlink and Genesis operational tests. Final report.

Federal Highway Administration, Washington, D.C.

The battle of belief : a review of the present aspects of the conflict /

Includes bibliographical references.

Human factors aspects of using head up displays in automobiles: a review of the literature.

National Highway Traffic Safety Administration, Washington, D.C.