Proceso de inspección

En la port.: Secretaría General de Salud Pública y Participación

Proceso de gestión de denuncias

El Manual de Procesos en Protección de la Salud estableció cuales eran los procesos operativos o claves que debían ser diseñados e implementados dentro del marco del II Plan de Calidad del Sistema Sanitario Publico de Andalucía. El fin último de elaborar un proceso operativo relacionado con las denuncias, es dar respuesta a la demanda habitual de la ciudadanía de poner en conocimiento de la Administración Pública los posibles incumplimientos o posibles riesgos en el ámbito de la protección de la salud.

Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients.

OBJECTIVE Zinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR). METHODS mRNA expression levels of PPARγ, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed. RESULTS The morbidly obese patients with low IR had a higher VAT ZAG expression as compared with the patients with high IR (p = 0.023). In the patients with low IR, the VAT ZAG expression was greater than that in SAT (p = 0.009). ZAG expression correlated between SAT and VAT (r = 0.709, p<0.001). VAT ZAG expression was mainly predicted by insulin, HOMA-IR, plasma adiponectin and expression of adiponectin and ACSS2. SAT ZAG expression was only predicted by expression of ATGL. CONCLUSIONS ZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance. These findings suggest that ZAG may be a useful target in obesity and related disorders, such as diabetes.

Manual de procesos en protección. 2ª ed.

En la port.: Secretaría General de Salud Pública, Inclusión Social y Calidad de Vida. 2ª EDICIÓN (2013), revisada por José Antonio Conejo Díaz, Catalina Gómez López, Francisco Chavernas Garvi, Alonso Ortiz Dominguez, Jesús Peinado Álvarez, José Pérez-Rendón González, María Fernanda Vallino Llabrés y José Vela Ríos.

Proceso de alertas. 2ª ed.

En la port.: Secretaría General de Salud Pública, Inclusión Social y Calidad de vida. 2ª EDICIÓN (2013), revisada por Luis Manuel Santiago Fernández, María José Viñuela González, Juan Antonio Ortiz Batanero, Carmen Añón García, Carmen Pacheco Rodríguez, María Zambrano Lozano, Juan Francisco Pereira Muñoz, José Luis Márquez Díaz, Ángel Mario Martín, Belén Ramos Fernández e Inmaculada Cuesta Bertomeu.

Proceso de alertas. 2ª ed.

En la port.: Secretaría General de Salud Pública, Inclusión Social y Calidad de vida. 2ª EDICIÓN (2013), revisada por Luis Manuel Santiago Fernández, María José Viñuela González, Juan Antonio Ortiz Batanero, Carmen Añón García, Carmen Pacheco Rodríguez, María Zambrano Lozano, Juan Francisco Pereira Muñoz, José Luis Márquez Díaz, Ángel Mario Martín, Belén Ramos Fernández e Inmaculada Cuesta Bertomeu.

El decreto de los inspectores farmacéuticos y veterinarios, un importante paso para el futuro de la salud pública

Boletín semanal para profesionales sanitarios de la Secretaría General de Salud Pública y Participación Social de la Consejería de Salud

Núm 1, mayo de 2013

Artículos destacados: Mito: El Sistema Sanitario Público es insostenible. Optimización de los tratamientos con antimicrobianos. Impacto de la crisis actual en la salud y en los sistemas sanitarios

Gut Microbiota Composition in Male Rat Models under Different Nutritional Status and Physical Activity and Its Association with Serum Leptin and Ghrelin Levels.

BACKGROUND Several evidences indicate that gut microbiota is involved in the control of host energy metabolism. OBJECTIVE To evaluate the differences in the composition of gut microbiota in rat models under different nutritional status and physical activity and to identify their associations with serum leptin and ghrelin levels. METHODS IN A CASE CONTROL STUDY, FORTY MALE RATS WERE RANDOMLY ASSIGNED TO ONE OF THESE FOUR EXPERIMENTAL GROUPS: ABA group with food restriction and free access to exercise; control ABA group with food restriction and no access to exercise; exercise group with free access to exercise and feed ad libitum and ad libitum group without access to exercise and feed ad libitum. The fecal bacteria composition was investigated by PCR-denaturing gradient gel electrophoresis and real-time qPCR. RESULTS In restricted eaters, we have found a significant increase in the number of Proteobacteria, Bacteroides, Clostridium, Enterococcus, Prevotella and M. smithii and a significant decrease in the quantities of Actinobacteria, Firmicutes, Bacteroidetes, B. coccoides-E. rectale group, Lactobacillus and Bifidobacterium with respect to unrestricted eaters. Moreover, a significant increase in the number of Lactobacillus, Bifidobacterium and B. coccoides-E. rectale group was observed in exercise group with respect to the rest of groups. We also found a significant positive correlation between the quantity of Bifidobacterium and Lactobacillus and serum leptin levels, and a significant and negative correlation among the number of Clostridium, Bacteroides and Prevotella and serum leptin levels in all experimental groups. Furthermore, serum ghrelin levels were negatively correlated with the quantity of Bifidobacterium, Lactobacillus and B. coccoides-Eubacterium rectale group and positively correlated with the number of Bacteroides and Prevotella. CONCLUSIONS Nutritional status and physical activity alter gut microbiota composition affecting the diversity and similarity. This study highlights the associations between gut microbiota and appetite-regulating hormones that may be important in terms of satiety and host metabolism.

MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations.

The development of Imatinib Mesylate (IM), the first specific inhibitor of BCR-ABL1, has had a major impact in patients with Chronic Myeloid Leukemia (CML), establishing IM as the standard therapy for CML. Despite the clinical success obtained with the use of IM, primary resistance to IM and molecular evidence of persistent disease has been observed in 20-25% of IM treated patients. The existence of second generation TK inhibitors, which are effective in patients with IM resistance, makes identification of predictors of resistance to IM an important goal in CML. In this study, we have identified a group of 19 miRNAs that may predict clinical resistance to IM in patients with newly diagnosed CML.

La austeridad mata: el coste humano de las políticas de recorte

Boletín semanal para profesionales sanitarios de la Secretaría General de Salud Pública y Participación Social, Inclusión y Calidad de vida de la Consejería de Salud y Bienestar Social