Thyroid metastasis as initial presentation of clear cell renal carcinoma.

INTRODUCTION Metastatic tumors account for 1.4-2.5% of thyroid malignancies. About 25-30% of patients with clear cell renal carcinoma (CCRC) have distant metastasis at the time of diagnosis, being the thyroid gland a rare localization [5%]. PRESENTATION OF THE CASE A 62-year woman who underwent a cervical ultrasonography and a PAAF biopsy reporting atypical follicular proliferation with a few intranuclear vacuoles "suggestive" of thyroid papillary cancer in the context of a multinodular goiter was reported. A total thyroidectomy was performed and the histology of a clear cell renal carcinoma (CCRC) was described in four nodules of the thyroid gland. A CT scan was performed and a renal giant right tumor was found. The patient underwent an eventful radical right nephrectomy and the diagnosis of CCRC was confirmed. DISCUSSION Thyroid metastasis (TM) from CCRC are usually apparent in a metachronic context during the follow-up of a treated primary (even many years after) but may sometimes be present at the same time than the primary renal tumor. Our case is exceptional because the TM was the first evidence of the CCRC, which was subsequently diagnosed and treated. CONCLUSION The possibility of finding of an incidental metastatic tumor in the thyroid gland from a previous unknown and non-diganosed primary (as CCRC in our case was) is rare and account only for less than 1% of malignancies. Nonetheless, the thyroid gland is a frequent site of metastasis and the presence of "de novo" thyroid nodules in oncologic patients must be always considered and studied.

Efecte de la recurrència dels incendis sobre la vegetació i el sòl a les zons de bosc del Macizo Central Ourensano

En els últims 30 anys, el número d’incendis patits a Galicia han augmentat de manera important. En el Massís Central Ourensano l’home ha utilitzat el foc com a eina de gestió forestal per tal de permetre pasturar al bestiar i per tal de recuperar terres per a pastos i culius. Aquesta pràctica ha generat grans extensions de matollar sec europeu on hi hauria d’haver formacions boscoses. Partim de la necessitat de recuperar zones de bosc i ecosistema original i per això mesurem el comportament de les diferents espècies que trobem al matollar y al bosc en aquestes altituds davant la pertorbació que suposen els incendis recurrents. Per realitzar això s’ha mostrejat la vegetació de zones cremades en moments diferents o repetides vegades, mesurant superfície i alçades així com nombre d’individus de cada espècie. També s’han analitzat perfils del sòl per tal de conèixer amb més detall les característiques de cada zona. S’ha observat mitjançant el mostreig com per a la recuperació del matollar el factor determinant és el temps, encara que no trobem un sòl de bona qualitat i profund, en una mitjana de 8 anys trobem un matollar ben desenvolupat amb una bona diversitat d’espècies i grau de cobertura. En canvi, per tal d’arribar a un estat de la successió vegetal on trobem un bosc és necessari que existeixin comunitats arbòries a prop per tal de que arribin individus al matollar desenvolupat. Cal aleshores treballar en l’educació de la població i en la cerca d’alternatives a la gestió forestal vigent, donant èmfasi en la valoració econòmica dels ecosistemes en bon estat i facilitant que aquest bon estat proporcioni beneficis a la població local. Per això cal generar una infraestructura per atraure un turisme rural respectuós amb el medi al mateix temps que es duen altres iniciatives com la implantació de centrals de biomassa als pobles que puguin proporcionar calefacció o aigua calenta. Generant llocs de feina i estalvis a la població d’una zona on l’economia encara es basa potencialment en la ramaderia. Al mateix temps l’esforç monetari dedicat a les plantacions ha de dedicar-se a generar espais al territori amb espècies autòctones com el roure en aquells matollars que presentin condicions adients per a recuperar el bosc.

Tecnologies de cloud computing Openstack/StackOps

El propòsit d'aquest TFC és investigar i fer una instal·lació des de zero d'un model de negoci basat en l'allotjament web fent servir tecnologies de Cloud Computing. El software open-source que es farà servir per aquesta finalitat serà Openstack el qual es basa en un model de servei com infraestructura (IaaS). La nostra finalitat és poder implementar el model IaaS basat en Openstack. Per duu a terme aquest desplegament es farà servir dos hipervisors (KVM i VMware ESXi) per tal de testejar diferents sistemes d¿hipervisors treballant conjuntament.

The implementation of liquid chromatography tandem mass spectrometry for the official control of lipophilic toxins in seafood: Single-laboratory validation under four chromatographic conditions

We performed a comprehensive study to assess the fit for purpose of four chromatographic conditions for the determination of six groups of marine lipophilic toxins (okadaic acid and dinophysistoxins, pectenotoxins, azaspiracids, yessotoxins, gymnodimine and spirolides) by LC-MS/MS to select the most suitable conditions as stated by the European Union Reference Laboratory for Marine Biotoxins (EURLMB). For every case, the elution gradient has been optimized to achieve a total run-time cycle of 12 min. We performed a single-laboratory validation for the analysis of three relevant matrices for the seafood aquaculture industry (mussels, pacific oysters and clams), and for sea urchins for which no data about lipophilic toxins have been reported before. Moreover, we have compared the method performance under alkaline conditions using two quantification strategies: the external standard calibration (EXS) and the matrix-matched standard calibration (MMS). Alkaline conditions were the only scenario that allowed detection windows with polarity switching in a 3200 QTrap mass spectrometer, thus the analysis of all toxins can be accomplished in a single run, increasing sample throughput. The limits of quantification under alkaline conditions met the validation requirements established by the EURLMB for all toxins and matrices, while the remaining conditions failed in some cases. The accuracy of the method and the matrix effects where generally dependent on the mobile phases and the seafood species. The MMS had a moderate positive impact on method accuracy for crude extracts, but it showed poor trueness for seafood species other than mussels when analyzing hydrolyzed extracts. Alkaline conditions with EXS and recovery correction for OA were selected as the most proper conditions in the context of our laboratory. This comparative study can help other laboratories to choose the best conditions for the implementation of LC-MS/MS according to their own necessities.

Protein phosphatase inhibition assays for okadaic acid detection in shellfish: matrix effects, applicability and comparison with LC-MS/MS analysis

The applicability of the protein phosphatase inhibition assay (PPIA) to the determination of okadaic acid (OA) and its acyl derivatives in shellfish samples has been investigated, using a recombinant PP2A and a commercial one. Mediterranean mussel, wedge clam, Pacific oyster and flat oyster have been chosen as model species. Shellfish matrix loading limits for the PPIA have been established, according to the shellfish species and the enzyme source. A synergistic inhibitory effect has been observed in the presence of OA and shellfish matrix, which has been overcome by the application of a correction factor (0.48). Finally, Mediterranean mussel samples obtained from Rı´a de Arousa during a DSP closure associated to Dinophysis acuminata, determined as positive by the mouse bioassay, have been analysed with the PPIAs. The OA equivalent contents provided by the PPIAs correlate satisfactorily with those obtained by liquid chromatography–tandem mass spectrometry (LC–MS/MS).

Aplicación cliente del sistema de control de presencia TamTam-Home para dispositivos Android

Aplicación cliente para dispositivos Android que permite a un usuario del sistema TamTam-Home acceder a sus datos y hacer un seguimiento en tiempo real de las entradas y salidas de su personal.

Levels of PSP toxins in bivalves exposed to natural blooms of Alexandrium minutum in Catalan harbours

The development, validation, comparison and evaluation of analytical methods for marine toxins rely on the availability of toxic material. Within the project JACUMAR PSP, our interest is mainly focused on autochthonous bivalve species with the toxic profile of Alexandrium minutum, since this is the principal species involved regionally in PSP outbreaks. Mussels and oysters were exposed during few days in the harbor of Vilanova i la Geltrú, to blooms reaching a maximum A. minutum concentration of 200,000 cells L-1 in 2008, and 40,000 and 800,000 cells L-1, in 2009. Mussels, oysters and clams were exposed to one bloom of 22,000 cells L-1 in the harbor of Cambrils in 2009. In all situations higher toxic levels analyzed by HPLC-FD with postcolumn oxidation were observed in mussels (i.e. 1,200-2,500 μg eq. STX kg-1) than in oysters (i.e. 60-800 μg eq. STX kg-1) exposed to the same bloom. Blooms with higher concentrations of A. minutum did not correspond to higher levels of PSP toxins in bivalves. These differences may be explained by differences in A. minutum population dynamics, toxin production or in the physiological state or behaviour of shellfish. These results confirm that mussels concentrate more PSP toxins from A. minutum than oysters and clams.

ScheUDLe generador d'horaris

La idea d'aquest projecte, neix de la complexitat per a la confecció d'horaris i distribució de professors en centres docents amb una gran quantitat de cursos, professors i assignatures. Amb scheUDLe es pretén simplificar aquesta tasca al màxim i reduir el gran treball que suposa quadrar hores i assignatures.

Utilización de herramientas de simulación en la robótica industrial

Análisis de herramienta de simulación utilizada en el entorno industrial y estudio de las ventajas de la programación "offline" en un entorno productivo. Programación de una célula de trabajo industrial y ampliación posterior de la misma utilizando la herramienta de simulación industrial.

Valorització sostenible del residu verd al municipi de Porqueres

Estudi de les possibles solucions per al tractament de la resta vegetal al municipi de Porqueres. S’estudia la tecnologia més eficient per valoritzar el residu verd per tal d’obtenir un producte final reutilitzable, beneficiós i sostenible, tant ambientalment com socialment. Actualment és tractat com a residu, la qual cosa suposa un cost de gestió important

O cuidado como uma Lei da Natureza: uma percepção integral do cuidar

Este trabalho faz uma reflexão entre a percepção do cuidar pelo profissional de enfermagem e a relação do significado dado ao termo Cuidar, que é um instrumento norteador da qualidade da assistência. Questiona o nível de profundidade do significado que essa palavra pode assumir, identificando sua presença em todos os processos do Universo e na história mitológica do ser humano. Propõe que o cuidar é a Lei que permite a manifestação dos potenciais de organização numa certa direção de estabilidade dinâmica, manifestos na matéria, até a promoção e estabelecimento da saúde e do bem-estar. Concluiu-se, afirmando que a Lei do Cuidar pode ser entendida como um conjunto de forças que permitem o prolongamento ou abreviamento de certo grau de organização, que pode ser expresso em diversos níveis.

Biopsia percutánea de la interfase protésica: técnica para el aislamiento preoperatorio del microorganismo patógeno en casos de infección periprotésica crónica con aspirado articular “seco”.

El objetivo de este estudio es determinar la valía diagnóstica de una biopsia de interfase protésica (BIP) preoperatoria para aislar la bacteria en casos de infección periprotésica crónica con aspirado articular “seco”. Para ello se realizó una revisión retrospectiva de 24 pacientes. Los resultados de los cultivos de la BIP se compararon con los resultados de los cultivos de las muestras intraoperatorias. La sensibilidad fue de un 88,2%, la especificidad del 100%, el valor predictivo positivo del 100% y el valor predictivo negativo del 77,9%. La eficacia global fue del 91,6%. La BIP resultó una prueba efectiva.

Lumen Dantis et Lumen Margaretae: el imaginario compartido por Dante Alighieri y Marguerite dicta Porete

In this article we compare the images used by Dante Alighieri with the ones used by her“heretical” contemporary Marguerite Porete (†1310) for expressing the final contact-vision of God. We will analyze the use of the images of light, the gradual ascent and the knot in bothauthors, putting it into the context of the theological doctrines about the visio Dei. This will allow us, in the first place, to claim a shared cultural background based in the conception of God as a visible being and, in the second, to discuss the historical implications ofheteredoxy/ortodoxy in the Commedia and the Mirouer.