Impact of Taylor-Aris diffusivity on analyte and system zone dispersion in CZE assessed by computer simulation and experimental validation.

Application of pressure-driven laminar flow has an impact on zone and boundary dispersion in open tubular CE. The GENTRANS dynamic simulator for electrophoresis was extended with Taylor-Aris diffusivity which accounts for dispersion due to the parabolic flow profile associated with pressure-driven flow. Effective diffusivity of analyte and system zones as functions of the capillary diameter and the amount of flow in comparison to molecular diffusion alone were studied for configurations with concomitant action of imposed hydrodynamic flow and electroosmosis. For selected examples under realistic experimental conditions, simulation data are compared with those monitored experimentally using modular CE setups featuring both capacitively coupled contactless conductivity and UV absorbance detection along a 50 μm id fused-silica capillary of 90 cm total length. The data presented indicate that inclusion of flow profile based Taylor-Aris diffusivity provides realistic simulation data for analyte and system peaks, particularly those monitored in CE with conductivity detection.

PICADAR: a diagnostic predictive tool for primary ciliary dyskinesia.

Symptoms of primary ciliary dyskinesia (PCD) are nonspecific and guidance on whom to refer for testing is limited. Diagnostic tests for PCD are highly specialised, requiring expensive equipment and experienced PCD scientists. This study aims to develop a practical clinical diagnostic tool to identify patients requiring testing.Patients consecutively referred for testing were studied. Information readily obtained from patient history was correlated with diagnostic outcome. Using logistic regression, the predictive performance of the best model was tested by receiver operating characteristic curve analyses. The model was simplified into a practical tool (PICADAR) and externally validated in a second diagnostic centre.Of 641 referrals with a definitive diagnostic outcome, 75 (12%) were positive. PICADAR applies to patients with persistent wet cough and has seven predictive parameters: full-term gestation, neonatal chest symptoms, neonatal intensive care admittance, chronic rhinitis, ear symptoms, situs inversus and congenital cardiac defect. Sensitivity and specificity of the tool were 0.90 and 0.75 for a cut-off score of 5 points. Area under the curve for the internally and externally validated tool was 0.91 and 0.87, respectively.PICADAR represents a simple diagnostic clinical prediction rule with good accuracy and validity, ready for testing in respiratory centres referring to PCD centres.

Isak Noah Mannheimer [Illustration] : nach einem im Besitz der Familie Finkel-Singer (Wien) befindlichen Original (geb. 1793 - gest. 1865)

Scan von Monochrom-Mikroform

Does the Federal Reserve Follow a Non-Linear Taylor Rule?

The Taylor rule has become one of the most studied strategies for monetary policy. Yet, little is known whether the Federal Reserve follows a non-linear Taylor rule. This paper employs the smooth transition regression model and asks the question: does the Federal Reserve change its policy-rule according to the level of inflation and/or the output gap? I find that the Federal Reserve does follow a non-linear Taylor rule and, more importantly, that the Federal Reserve followed a non-linear Taylor rule during the golden era of monetary policy, 1985-2005, and a linear Taylor rule throughout the dark age of monetary policy, 1960-1979. Thus, good monetary policy is associated with a non-linear Taylor rule: once inflation approaches a certain threshold, the Federal Reserve adjusts its policy-rule and begins to respond more forcefully to inflation.

Franceschina Prevosti, Mary Prevosti, Doppelbildnis

Signatur des Originals: S 36/F01550

Charlotte Wolter als Jane Eyre, Rollenbild, in: Charlotte Birch-Pfeiffer: Die Waise aus Lowood, Wien: Burgtheater

Signatur des Originals: S 36/F02186

Peter Benoît, Brustbild, Profil, 1865

Signatur des Originals: S 36/F02988

Peter Benoît, Brustbild, Profil, 1865

Signatur des Originals: S 36/F02989

Mary Brand als Salomé, Rollenbild, in: Oscar Wilde: Salomé

Signatur des Originals: S 36/F03149

Mary Brand als Salomé, Rollenbild, in: Oscar Wilde: Salomé

Signatur des Originals: S 36/F03150

Sarah Jane Walker, Kniestück

Signatur des Originals: S 36/F03308

Sarah Jane Walker, Hüftbild

Signatur des Originals: S 36/F03309

Sarah Jane Walker, Rollenbild, Brustbild

Signatur des Originals: S 36/F03310

Mary Grasenick, Brustbild

Signatur des Originals: S 36/F04225