Cyclic Cationic Peptides Containing Sugar Amino Acids Selectively Distinguishes and Inhibits Maturation of Pre-miRNAs of the Same Family

The discovery of microRNAs (miRNAs) has added a new dimension to the gene regulatory networks, making aberrantly expressed miRNAs as therapeutically important targets. Small molecules that can selectively target and modulate miRNA levels can thus serve as lead structures. Cationic cyclic peptides containing sugar amino acids represent a new class of small molecules that can target miRNA selectively. Upon treatment of these small molecules in breast cancer cell line, we profiled 96 therapeutically important miRNAs associated with cancer and observed that these peptides can selectively target paralogous miRNAs of the same seed family. This selective inhibition is of prime significance in cases when miRNAs of the same family have tissue-specific expression and perform different functions. During these conditions, targeting an entire miRNA family could lead to undesired adverse effects. The selective targeting is attributable to the difference in the three-dimensional structures of precursor miRNAs. Hence, the core structure of these peptides can be used as a scaffold for designing more potent inhibitors of miRNA maturation and hence function.

Speaker verification based on the fusion of speech acoustics and inverted articulatory signals

We propose apractical, feature-level and score-level fusion approach by combining acoustic and estimated articulatory information for both text independent and text dependent speaker verification. From a practical point of view, we study how to improve speaker verification performance by combining dynamic articulatory information with the conventional acoustic features. On text independent speaker verification, we find that concatenating articulatory features obtained from measured speech production data with conventional Mel-frequency cepstral coefficients (MFCCs) improves the performance dramatically. However, since directly measuring articulatory data is not feasible in many real world applications, we also experiment with estimated articulatory features obtained through acoustic-to-articulatory inversion. We explore both feature level and score level fusion methods and find that the overall system performance is significantly enhanced even with estimated articulatory features. Such a performance boost could be due to the inter-speaker variation information embedded in the estimated articulatory features. Since the dynamics of articulation contain important information, we included inverted articulatory trajectories in text dependent speaker verification. We demonstrate that the articulatory constraints introduced by inverted articulatory features help to reject wrong password trials and improve the performance after score level fusion. We evaluate the proposed methods on the X-ray Microbeam database and the RSR 2015 database, respectively, for the aforementioned two tasks. Experimental results show that we achieve more than 15% relative equal error rate reduction for both speaker verification tasks. (C) 2015 Elsevier Ltd. All rights reserved.

Role of spacer length in interaction between novel gemini imidazolium surfactants and Rhizopus oryzae lipase

An insight into the effects of new ionic liquid-type gemini imidazolium cationic surfactants on the structure and function of the lipases is of prime importance for their potential application. Changes in the activity, stability and structure of Rhizopus ouzae lipase in the presence of novel gemini surfactants, C-16-3-C(16)im]Br-2 and C-16-12-C(16)im]Br-2 were probed in the present study. Surfactant with shorter spacer length, C-16-3-C(i6)im]Br-2 was found to be better in improving the hydrolytic activity and thermal stability of the lipase. For both the surfactants, activation was concentration dependent. CD spectroscopy results showed a decrease in a-helix and an increase in beta-sheet content in the presence of these surfactants. A higher structural change observed in presence of C-16-12-C(16)im]Br-2 correlated with lower enzyme activity. Isothermal titration calorimetric studies showed the binding to be spontaneous in nature based on sequential two site binding model. The forces involved in binding were found to differ for the two surfactants proving that the spacer length is an important factor which governs the interaction. These surfactants could be used as promising components both in enzyme modification and media engineering for attaining the desired goals in biocatalytic reactions. (C) 2015 Elsevier B.V. All rights reserved.

Computationally efficient models for simulation of non-ideal DC-DC converters operating in continuous and discontinuous conduction modes

This paper discusses dynamic modeling of non-isolated DC-DC converters (buck, boost and buck-boost) under continuous and discontinuous modes of operation. Three types of models are presented for each converter, namely, switching model, average model and harmonic model. These models include significant non-idealities of the converters. The switching model gives the instantaneous currents and voltages of the converter. The average model provides the ripple-free currents and voltages, averaged over a switching cycle. The harmonic model gives the peak to peak values of ripple in currents and voltages. The validity of all these models is established by comparing the simulation results with the experimental results from laboratory prototypes, at different steady state and transient conditions. Simulation based on a combination of average and harmonic models is shown to provide all relevant information as obtained from the switching model, while consuming less computation time than the latter.

Beyond Schur's Conjecture

Schur 4] conjectured that the maximum length N of consecutive quadratic nonresidues modulo a prime p is less than root p if p is large enough. This was proved by Hummel in 2003. In this note, we outline a clear improvement over Hummel's bound for p > 23.

Beyond Schur's Conjecture

Schur 4] conjectured that the maximum length N of consecutive quadratic nonresidues modulo a prime p is less than root p if p is large enough. This was proved by Hummel in 2003. In this note, we outline a clear improvement over Hummel's bound for p > 23.

Estados Unidos : ¿ante una suba de tasas de interés en 2015?

Introducción: A raíz de la crisis de hipotecas sub-prime de 2008 en Estados Unidos, tanto la Reserva Federal (FED) como los demás bancos centrales del mundo (en especial, el Banco Central Europeo y el de Japón actualmente) comenzaron a aplicar un continuo estímulo monetario vía bajas tasas de interés (cercanas a cero en los tres casos). Dicha política monetaria activa fue efectiva, en el caso de Estados Unidos, para otorgar liquidez al mercado y actuar sobre las expectativas de los agentes. De este modo, además de generarse una importante recuperación de valor en los activos y un colapso en las yields de la parte larga de la curva de bonos soberanos, se comenzó a observar una muy gradual mejora en la economía real, la cual viene siendo cada vez más robusta a juzgar por ciertos indicadores que se verán más adelante en este ensayo...

Informe de Economía e Instituciones

Resumen: En su quinto número el Informe de Economía e Instituciones cuenta con tres columnas que abordan cuestiones teóricas y de política económica relacionadas con la temática de la economía y las instituciones. En la primera columna, La crisis financiera y el debate regulatorio, presenta una explicación institucional a la crisis hipotecaria actual en Estados Unidos. Según el autor en el origen de la inestabilidad del sistema financiero, que produjo consecutivos efectos de “burbujas” bursátiles se encuentra la revolución tecnológica y una desregulación imprudente de los sistemas financieros desde los años 1980. Con respecto a las soluciones en curso se resalta que las medidas que no incluyan, aparte de soluciones coyunturales como los rescates de entidades bancarias y financieras, una reformulación de las regulaciones no podrán atacar el problema en toda su magnitud. En la segunda columna, Causas institucionales de la crisis económica mundial, se enfoca en las causas de la crisis actual, que según el autor provienen de notorias fallas institucionales. El vacío de reglas prudenciales en las hipotecas sub-prime produjo primero una “burbuja” en el precio de los inmuebles y luego, al colapsar ésta, condujo a elevados porcentajes de incobrabilidad. Un rasgo en la organización institucional de la sociedad es evitar que alguien sea “juez y parte” en un tema, evitando asimetrías en la información y lobbies. Por último, se comenzó a transferir a los ahorristas el riesgo crediticio, esto transforma esencialmente la función del sector bancario de evaluadores de riesgos a vendedores de bonos. En la tercera columna, Los subsidios estatales en un contexto de vacío institucional, se puntualiza que la absoluta discrecionalidad de que gozan los gobiernos para disponer la asignación de dineros públicos vía subsidios es una constante histórica, que en los países más avanzados a comenzado a revertirse. El crecimiento explosivo de los subsidios en nuestro país durante los últimos años, en un marco de vacío de reglas jurídicas que fijen ciertos criterios imperativos para el gobierno, ha conducido a situaciones de marcada ineficiencia. Existen muchas recetas para revertir tal escenario, pero lo complejo es encontrar la llave para torcer la natural resistencia de los gobiernos a crear sistemas que los limiten en ese terreno.

Materia, forma y privación en el opúsculo de “Principiis naturae” de Santo Tomás de Aquino

Resumen: En este trabajo seguimos la presentación de la materia, la forma y la privación realizada por Santo Tomás de Aquino en los dos primeros capítulos del De principiis naturae. Identificados como los principios de la naturaleza, son la clave para entender las definiciones de generación de las que nos provee el Aquinate. Él entiende la generación, protagonista de los cambios del mundo material, en sus principios, descubiertos en sus relaciones acto-potenciales. Completa esta presentación la distinción entre las substancias y los accidentes y sus consecuencias en el campo de los cambios de los cuerpos. Luego, Santo Tomás extiende los análisis de la privación y de la materia. La privación, entonces, es bien distinguida de la negación, porque el Aquinate muestra su dimensión potencial. La materia, por otro lado, se descubre en su pluralidad de sentidos y nos permite hablar de una participación de la materia, a partir de la principalísima materia ex qua o primera. Por último, tomamos nota de las fuentes secundarias de este texto, revisando pasajes de San Agustín y Averroes.

助推-远程滑翔三维飞行的热流峰值分析

为简便分析助推-远程滑翔弹道三维情况下的热流特性,基于远程滑翔三维飞行动力学模型和热力学基本公式,根据助推-远程滑翔弹道的两类飞行弹道（平衡滑翔弹道和跳跃滑翔弹道）的特点,推导建立了两类弹道三维情况下平均热流和驻点热流计算的解析公式。详尽分析了再入角、再入速度、升阻比、滚转角和翼载荷对两类弹道热流峰值的影响规律。由分析可知在远程滑翔三维飞行情况下,滚转角对其热流峰值有显著影响;升阻比大于1,滚转角控制在60度以内,其热流峰值能够得到有效降低。

Evaluation of SP1001 (Pelargonic Acid) in Combination with Glyphosate on Cattail and Alligatorweed

Cattail (Typha latifolia L.) is a common and troublesome weed in shallow, freshwater environments throughout the United States. Alligatorweed (Alternanthera philoxeroides (Mart.)Griseb.), in spite of the introduction and success of several insects as biological controls, remains a troublesome we4ed in a a number of locations in the Southeast where there are frequent human disturbances (e.g., insecticide spraying, mechaniceal removal, etc.) and/or weather conditions that affect the life cycle of the insects (Kay1992, Vogt et al. 1992). Both of these weeds routinely are managed by foliar applications of the herbicide, glyphosate [N-(phosphonomethyl)glycine]. Regrowth and reinfestation of previously treated areas usually necessitates additional herbicide application during subsequent years. A new product that could enhance the activity of glyphosate on these weeds would be useful in their management. In 1997, SePRO Corp. initiated t4esting of an experimental compound, SP1001, to determine its efficacy either as a herbicide or as an adjuvant to boost the activity of glyphosate for use in aquatic sites. The objective of this study was to evaluate the potential for using SP1001 as an adjuvant to replace surfactants customarily used during application of glyphosate for control of cattail and alligatorweed.

Aquaculture Asia, Vol.14, No.1, pp.1-51, January-March 2009

Peter Edwards writes on rural aquaculture: Myanmar revisited. Harvesting, traditional preservation and marketing of fishes of Chalan Beel, Bangladesh, by Galib, S.M. and Samad, M.A. Role of community in production and supply of larger, quality fingerlings, by Radheyshyam, De, H.K. and Saha, G.S. Can rice-fish farming provide food security in Bangladesh? by Ahmed, N. and Luong-Van, J. Nutritional and food security for rural poor through multi-commodity production from a lake of eastern Uttar Pradesh, by Singh, S.K. Emerging boost in Sri Lankan reservoir fish production: a case of adoption of past research findings, by Amarasinghe, U.S., Weerakoon, D.E.M., Athukorala, D.A. Farming the freshwater prawn Macrobrachium malcolmsonii, by Radheyshyam Breeding and seed production of butter catfish, Ompok pabda (Siluridae) at Kalyani Centre of CIFA, India, by Chakrabarti, P.P., Chakrabarty, N.M. and Mondal, S.C. Asia-Pacific Marine Finfish Aquaculture Magazine Use of fish in animal feeds: a fresh perspective National strategies for aquatic animal health management, by Mohan, C.V. NACA Newsletter.

Microstructure Evolution of Laser Pulse processed Ductile Iron Surface

Pulsed laser beam was used to modify surface processing for ductile iron. The microstructures of processed specimen were observed using optical microscope (OM). Nanoindentation and micro-hardness of microstructures were measured from surface to inner of sample. The experimental results show that, modification zone is consisted of light melted zone, phase transformation hardening area and transient area. The light melt area is made up of coarse dendrite crystalline with a thickness less than 20um, phase transformation hardening area mainly of laminal or acicular martensite, retained austenite and graphite, i.e. M+A prime+ G. The cow-eye microstructure around graphite sphere always is formed in phase transformation hardening area zone, which consisting of a variety structure with the distance from the surface. So, it maybe as a obvious sign distinguishing modification zone border. Finally, the microstructures evolution of laser pulse processed ductile iron was analyzed coupling with beam energy distribution in space and laser pulse heating procession characteristics. The analysis shows that energy distribution of laser pulse has an important effect on microstructure during laser pulse modified ductile iron. Multi-scale and interlace arrangement are the important features for laser pulse modified ductile iron. Of microstructure.

Adapting integrated agriculture aquaculture for HIV and AIDS-affected households: the case of Malawi

The WorldFish Center in conjunction with World Vision Malawi carried out a project to improve income and nutrition status of households affected by HIV and AIDS with funding from the World Bank. The project was implemented in Southern Malawi particularly in the West of Zomba District from July 2005 to June 2006. Through participatory approaches, the project identified constraints that limit HIV and AIDS affected households’ realisation of the benefits from fish farming and adapted technologies and practices for the affected beneficiaries to boost fish production and utilization. Specifically, the project sought (1) to identify the constraints that limit HIV and AIDS affected households to realise the benefits from fish farming and based on the constraints, (2) to adapt technologies and practices for use by the affected beneficiaries to boost fish production and utilization. (PDF cotains 17 pages)

Management of northern fur seals on the Pribilof Islands, Alaska, 1786-1981

This paper includes information about the Pribilof Islands since their discovery by Russia in 1786 and the population of northern fur seals, Cailorhinus ursinus, that return there each summer to bear young and to breed. Russia exterminated the native population of sea Oilers, Enhydra lulris, here and nearly subjected the northern fur seal to the same fate before providing proper protection. The northern fur seal was twice more exposed to extinction following the purchase of Alaska and the Pribilof Islands by the United States in 1867. Excessive harvesting was stopped as a result of strict management by the United States of the animals while on land and a treaty between Japan, Russia, Great Britain (for Canada), and the United States that provided needed protection at sea. In 1941, Japan abrogated this treaty which was replaced by a provisional agreement between Canada and the United States that protected the fur seals in the eastern North Pacific Ocean. Japan, the U.S.S.R., Canada, and the United States again insured the survival of these animals with ratification in 1957 of the "Interim Convention on the Conservation of North Pacific Fur Seals," which is still in force. Under the auspices of this Convention, the United States launched an unprecedented manipulation of the resource through controlled removal during 1956-68 of over 300,000 females considered surplus. The biological rationale for the reduction was that production of fewer pups would result in a higher pregnancy rate and increased survival, which would, in turn, produce a sustained annual harvest of 55,000-60,000 males and 10,000-30,000 females. Predicted results did not occur. The herd reduction program instead coincided with the beginning of a decline in the number of males available for harvest. Suspected but unproven causes were changes in the toll normally accounted for by predation, disease, adverse weather, and hookworms. Depletion of the animals' food supply by foreign fishing Heets and the entanglement of fur seals in trawl webbing and other debris discarded at sea became a prime suspect in altering the average annual harvest of males on the Pribilof Islands from 71,500 (1940-56) to 40,000 (1957-59) to 36,000 (1960) to 82,000 (1961) and to 27,347 (1972-81). Thus was born the concept of a research control area for fur seals, which was agreed upon by members of the Convention in 1973 and instituted by the United States on St. George Island beginning in 1974. All commercial harvesting of fur seals was stopped on St. George Island and intensive behavioral studies were begun on the now unharvested population as it responds to the moratorium and attempts to reach its natural ceiling. The results of these and other studies here and on St. Paul Island are expected to eventually permit a comparison between the dynamics of unharvested and harvested populations, which should in turn permit more precise management of fur seals as nations continue to exploit the marine resources of the North Pacific Ocean and Bering Sea. (PDF file contains 32 pages.)