Impact of Early Postnatal Androgen Exposure on Voice Development

Background: the impact of early postnatal androgen exposure on female laryngeal tissue may depend on certain characteristics of this exposure. We assessed the impact of the dose, duration, and timing of early androgen exposure on the vocal development of female subjects who had been treated for adrenocortical tumor (ACT) in childhood.Methods: the long-term effects of androgen exposure on the fundamental vocal frequency (F0), vocal pitch, and final height and the presence of virilizing signs were examined in 9 adult (age, 18.4 to 33.5 years) and 10 adolescent (13.6 to 17.8 years) female ACT patients. We also compared the current values with values obtained 0.9 years to 7.4 years after these subjects had undergone ACT surgery, a period during which they had shown normal androgen levels.Results: of the 19 subjects, 17 (89%) had been diagnosed with ACT before 4 years of age, 1 (5%) at 8.16 years, and 1 (5%) at 10.75 years. Androgen exposure (2 to 30 months) was sufficiently strong to cause pubic hair growth in all subjects and clitoromegaly in 74% (14/19) of the subjects, but did not reduce their height from the target value. Although androgen exposure induced a remarkable reduction in F0 (132 Hz) and moderate pitch virilization in 1 subject and partial F0 virilization, resulting in F0 of 165 and 169 Hz, in 2 subjects, the majority had normal F0 ranging from 189 to 245 Hz.Conclusions: Female laryngeal tissue is less sensitive to androgen exposure between birth and adrenarche than during other periods. Differential larynx sensitivity to androgen exposure in childhood and F0 irreversibility in adulthood are age-, concentration-, duration-, and timing-dependent events that may also be affected by exposure to inhibitory or stimulatory hormones. Further studies are required to better characterize each of these factors.

Model-based detection of spiculated lesions in mammograms

R. Zwiggelaar, T.C. Parr, J.E. Schumm. I.W. Hutt, S.M. Astley, C.J. Taylor and C.R.M. Boggis, 'Model-based detection of spiculated lesions in mammograms', Medical Image Analysis 3 (1), 39-62 (1999)

HIV/AIDS and national security

McInnes, C., 'HIV/AIDS and national security', in: AIDS and Governance, N. Poku, A. Whiteside and B. Sandkjaer (eds.),(Aldershot: Ashgate, 2007), pp.93-111 RAE2008

(O)znaki śmierci w polskiej poezji po roku 1956

Wydział Filologii Polskiej i Klasycznej: Instytut Filologii Polskiej

Nouvelles approches de la ville dans la littérature française contemporaine : Thomas Clerc et Philippe Vasset

On the basis of two indecidable texts (Thomas Clerc, “Paris, musée du XXIe siècle. Le dixième arrondissement”, Gallimard 2007 and Philippe Vasset, “Un livre blanc”, Fayard 2007), we will reflect on new approaches to the city in contemporary French litterature. Clerc and Vasset, in their respective texts, suggest considering litterature as a series of practices connected with the exploration of the city (Clerc) and of the urban area (Vasset) according to the idea of an arbitrary itinerary. The image of the city whose space, subject to a permanent process of museifi cation, is constantly considered to be a work of art (Clerc) contrasts with a project of viewing the deserted areas of the city and of its surroundings as an infinite collection of “artistic installations” created in daily life (Vasset). Clerc’s and Vasset’s artistic mentality leads them to the fascination with “works of involuntary art”, both concrete signs and tangible proof of the transitional period which they try to describe systematically, following, at the same time, the principles of an axonometric city map.

Wergiliusz jako twórca labiryntu

Romani antiqui putabant litteras aedificiis similes esse. Nonnulli scriptores Latini tali modo metaphoras suas composuerunt, ut descriptio aedificii una cum descriptione operis poetici esset. Aeneis etiam effigiem suam continet, quae est ecphrasis portae templi Apollinis. In fabulam Aeneae Vergilius fabulam Daedali introduxit, quae diu doctis ad nihil pertinere videbatur. Falsissime quidem, quia non solum coniunctio fabularum exsistit, sed etiam multae sunt causae fabulae Daedali hoc loco imponendae. Imprimis caelamen monstrat multos casus ex vita Daedali et Aeneae similes fuisse, deinde ostendere Daedalum creatorem hibridarum esse videtur. Aeneis etiam hibrida est, quia constat ex duabus partibus, quae sunt, ut ita dicam, „pars Odysseica” et „pars Iliadica”. Utri (Daedalus Vergiliusque scilicet) sunt ergo creatores hibridarum. Maximi momenti est quaestio: quis dicit “miserum!” in hac parte poematis? Auctrix commentationis censet illum clamantem Vergilium esse, quia poeta constructorem „alter ego” suum esse credebat. Auctrix scripsit etiam imaginem illam, in qua caelata est fabula de Minotauro sine Theseo, viam esse pietatis Aeneae minuendae. Scripsit verba illa quoque opinionem Vergilii de natura poesis et vocem Augusti absconditam esse.

Zmienne graficzne sygnatur punktowych w mobilnym systemie rozszerzonej rzeczywistości

Wydział Nauk Geograficznych i Geologicznych

A Doença Celíaca

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas

Síndrome de Kelly

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária

Prevalência de sinais e sintomas de Disfunções Temporomandibulares em pacientes que se dirigem à consulta de Otorrinolaringologia

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária

A desidratação no idoso

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas

A Síndrome progeróide de Hutchinson-Gilford e suas complicações na cavidade oral

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária

Sintomatologia associada à erupção dentária

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária

Controlo do tratamento endodontico não-cirúrgico de dentes com diagnóstico de necrose pulpar associada ou não a lesão apical

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Medicina Dentária

Occupational lead neurotoxicity: A behavioural and electrophysiological evaluation. study design and year one results.

To evaluate the effects of chronic lead exposure on the nervous system in adults, a set of neurobehavioural and electrophysiological tests was administered to 99 lead exposed foundry employees and 61 unexposed workers. Current and past blood lead concentrations were used to estimate the degree of lead absorption; all previous blood lead concentrations had been less than or equal to 90 micrograms/100 ml. Characteristic signs (such as wrist extensor weakness) or symptoms (such as colic) of lead poisoning were not seen. Sensory conduction in the sural nerve was not affected. By contrast, various neurobehavioural functions deteriorated with increasing lead burden. Workers with blood lead concentrations between 40 and 60 micrograms/100 ml showed impaired performance on tests of verbal concept formation, visual/motor performance, memory, and mood. Thus impairment in central nervous system function in lead exposed adults occurred in the absence of peripheral nervous system derangement and increased in severity with increasing lead dose.