ABD e-News, October 24, 2003

Weekly newsletter for the State of Iowa Alcoholic Beverages Division

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ABD e-News, October 10, 2003

Weekly newsletter for the State of Iowa Alcoholic Beverages Division

ABD e-News October 17, 2003

Weekly newsletter for the State of Iowa Alcoholic Beverages Division

Smart News, Issue 9, 2003

Newsletter for Economic Development.

Distribution of free and conjugated cannabinoids in human bile samples.

The metabolism of Δ(9)-tetrahydrocannabinol (THC) is relatively complex, and over 80 metabolites have been identified. However, much less is known about the formation and fate of cannabinoid conjugates. Bile excretion is known to be an important route for the elimination of phase II metabolites. A liquid chromatography-tandem mass spectrometry LC-MS/MS procedure for measuring cannabinoids in oral fluid was adapted, validated and applied to 10 bile samples. THC, 11-hydroxy-Δ(9)-tetrahydrocannabinol (11-OH-THC), 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THCCOOH), cannabinol (CBN), cannabidiol (CBD), Δ(9)-tetrahydrocannabinolic acid A (THC-A), 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol glucuronide (THCCOOH-gluc) and Δ(9)-tetrahydrocannabinol glucuronide (THC-gluc) were determined following solid-phase extraction and LC-MS/MS. High concentrations of THCCOOH-gluc were found in bile samples (range: 139-21,275 ng/mL). Relatively high levels of THCCOOH (7.7-1548 ng/mL) and THC-gluc (38-1366 ng/mL) were also measured. THC-A, the plant precursor of THC, was the only cannabinoid that was not detected. These results show that biliary excretion is an important route of elimination for cannabinoids conjugates and that their enterohepatic recirculation is a significant factor to consider when analyzing blood elimination profiles of cannabinoids. Furthermore, we suggest that the bile is the matrix of choice for the screening of phase II cannabinoid metabolites.

Distribution des durées de séjour par Diagnosis Related Group

Ce cahier fournit les principales informations concernant les durées de séjour et le nombre de sorties observées dans 33 hôpitaux suisses pour l'années 1984. La description des clientèles hospitalières est fondée sur les "Diagnosis Related Groups" (DRG), qui forment une classification de 472 groupes de patients hospitalisés. [Auteurs, p. 1]

Iowa 100% E News, February 2001, Vol.1, no.1

Newsletter for Information Technology Department

Iowa 100% E News, March 2001, Vol.1, no.2

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Iowa 100% E News, April 2001, Vol.1, no.3

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Iowa 100% E News, May/June 2001, Vol.1, no.4

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Iowa 100% E News, July/August 2001, Vol.1, no.5

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Iowa 100% E News, August/September 2001, Vol.1, no.6

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Iowa 100% E News, December 2001, Vol.1 no.8

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