MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines

Several noncoding microRNAs (miR or miRNA) have been shown to regulate the expression of drug-metabolizing enzymes and transporters. Xenobiotic drug-induced changes in enzyme and transporter expression may be associated with the alteration of miRNA expression. Therefore, this study investigated the impact of 19 xenobiotic drugs (e. g. dexamethasone, vinblastine, bilobalide and cocaine) on the expression of ten miRNAs (miR-18a, -27a, -27b, -124a, -148a, -324-3p, -328, -451, -519c and -1291) in MCF-7, Caco-2, SH-SY5Y and BE(2)-M17 cell systems. The data revealed that miRNAs were differentially expressed in human cell lines and the change in miRNA expression was dependent on the drug, as well as the type of cells investigated. Notably, treatment with bilobalide led to a 10-fold increase of miR-27a and a 2-fold decrease of miR-148a in Caco-2 cells, but no change of miR-27a and a 2-fold increase of miR-148a in MCF-7 cells. Neuronal miR-124a was generally down-regulated by psychoactive drugs (e. g. cocaine, methadone and fluoxetine) in BE(2)-M17 and SH-SY5Y cells. Dexamethasone and vinblastine, inducers of drug-metabolizing enzymes and transporters, suppressed the expression of miR-27b, -148a and -451 that down-regulate the enzymes and transporters. These findings should provide increased understanding of the altered gene expression underlying drug disposition, multidrug resistance, drug-drug interactions and neuroplasticity. Copyright (C) 2011 John Wiley & Sons, Ltd.

Otto Klitgord at 1952 Commencement

Otto Klitgord (second from left) is pictured with other guests at the Hotel St. George, site of the February 1952 commencement ceremony of the college. Otto Klitgord was the first president of the New York City College of Technology. He was named director of the New York State Institute of Applied Arts and Sciences when it was formed in the 1946 and became president in the 1950s when the administration was reorganized. Klitgord served until 1960, making his tenure as president the longest in City Tech's history.

Otto Klitgord and Andrew Clauson

Otto Klitogord (left) is depicted awarding the Hon. Andrew Clauson (right) with membership in TPS - June 26, 1952. Otto Klitgord was the first president of the New York City College of Technology. He was named director of the New York State Institute of Applied Arts and Sciences when it was formed in the 1946 and became president in the 1950s when the administration was reorganized. Klitgord served until 1960, making his tenure as president the longest in City Tech's history.

Otto Klitgord and Lawrence J. Jarvie

Otto Klitgord (left) and Lawrence Jarvie (right) are pictured at a college dinner. Otto Klitgord was the first president of the New York City College of Technology. He was named director of the New York State Institute of Applied Arts and Sciences when it was formed in the 1946 and became president in the 1950s when the administration was reorganized. Klitgord served until 1960, making his tenure as president the longest in City Tech's history.

Otto Klitgord at 1951 Commencement Ceremony

Otto Klitgord is presiding over the May 24, 1951 commencement ceremony of the New York State Institute of Applied Arts and Sciences held in Carnegie Hall. Otto Klitgord was the first president of the New York City College of Technology. He was named director of the New York State Institute of Applied Arts and Sciences when it was formed in the 1946 and became president in the 1950s when the administration was reorganized. Klitgord served until 1960, making his tenure as president the longest in City Tech's history.

Otto Klitgord and Major Benjamin Namm

Otto Klitgord is depicted giving Benjamin H. Namm, chairman of the college's Board of Trustees a degree. Otto Klitgord was the first president of the New York City College of Technology. He was named director of the New York State Institute of Applied Arts and Sciences when it was formed in the 1946 and became president in the 1950s when the administration was reorganized. Klitgord served until 1960, making his tenure as president the longest in City Tech's history.

Otto Klitgord

This photo shows Otto Klitgord speaking at a college event. Otto Klitgord was the first president of the New York City College of Technology. He was named director of the New York State Institute of Applied Arts and Sciences when it was formed in the 1946 and became president in the 1950s when the administration was reorganized. Klitgord served until 1960, making his tenure as president the longest in City Tech's history.

The LaGuardia - Red Hook Caregiver

Vol. II, No. 2; This document was produced as a result of a training and development project for staff in the social services system through a contractual agreement between the New York State Department of Social Services and the Research Foundation of the City University of New York on behalf of La Guardia Community College. No date, library receipt, 1979.

The LaGuardia - Red Hook Caregiver

Vol. I, No. 5; This document was produced as a result of a training and development project for staff in the social services system through a contractual agreement between the New York State Department of Social Services and the Research Foundation of the City University of New York on behalf of La Guardia Community College. No date, library receipt, 30 January 1979.

The LaGuardia - Red Hook Caregiver

Vol. II, No. 3; This document was produced as a result of a training and development project for staff in the social services system through a contractual agreement between the New York State Department of Social Services and the Research Foundation of the City University of New York on behalf of La Guardia Community College. No date, library receipt, 13 September 1979.

Housing codes : the key to housing conservation /

Cover title.

Housing codes : the key to housing conservation : a demonstration project /

Cover title.

Bulletin /

Title from cover.