Reliure de : M. Annaei Lucani pharsalia, sive de bello civili Caesaris et Pompeii lib. X. Ex emendatione V.C. Hug : Grotii.

[La guerre civile (latin). 1626]

Reliure de : Luciani Samosatensis Opera quae quidem extant omnia, e graeco sermone in latinum, partim jam olim diversis autoribus, partim nunc demum per Jacobum Micyllum, quaecunque reliqua fuere translata. Cum argumentis et annotationibus ejusdem passim adjectis... Francoforti, apud Chrisitanum Egenolphum Hadamarium. - "A la fin" : Francoforti, Christianus Aegenolphus excudebat, mense martio, anno M.D.XXXVIII

Numérisation partielle de reliure

A non-random chromosome abnormality found in precursor-B lineage acute lymphoblastic leukaemia: dic(9;20)(p1?3;q11).

A comparison of cytogenetical data on acute lymphoblastic leukaemia studied at four large European centres has revealed a non-random dicentric chromosome abnormality: dic(9;20) (p1?3;q11) in 10 patients, nine of whom were children. All had early precursor-B lineage ALL, and eight children had a non-standard risk clinical presentation. The origin of the dicentric chromosome was demonstrated using a range of chromosome banding techniques. This was confirmed by FISH using paints and centromeric probes for chromosomes 9 and 20, together with a number of cosmid probes. The follow-up time of these patients is presently too short and the number of patients too few to determine the prognostic significant of this chromosome abnormality.

Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice.

The antidiuretic effect of vasopressin is mediated by V2 receptors (V2R) that are located in kidney connecting tubules and collecting ducts. This study provides evidence that V2R signaling is negatively regulated by regulator of G protein signaling 2 (RGS2), a member of the family of RGS proteins. This study demonstrates that (1) RGS2 expression in the kidney is restricted to the vasopressin-sensitive part of the nephron (thick ascending limb, connecting tubule, and collecting duct); (2) expression of RGS2 is rapidly upregulated by vasopressin; (3) the vasopressin-dependent accumulation of cAMP, the principal messenger of V2R signaling, is significantly higher in collecting ducts that are microdissected from the RGS2(-/-) mice compared with their wild-type littermates; and (4) analysis of urine output of mice that were exposed to water restriction followed by acute water loading revealed that RGS2(-/-) mice exhibit an increased renal responsiveness to vasopressin. It is proposed that RGS2 is involved in negative feedback regulation of V2R signaling.

[Illustrations de La Gloire du Val-de-Grâce] / Pierre Mignard, dess. ; François Chauveau, grav.

Comprend : [Fig. à la Page de Titre : cartouche avec devise, ange et soldat.] In Hoc Signo Vinces. [Cote : Ye 669/Microfilm R 122335] ; [Fronstispice après la Page de Titre : Le Parnasse, Apolllon et les Muses.] [Cote : Ye 669/Microfilm R 122335] ; [Bandeau et lettre historiée folio Aiij : putti dessinant, travaillant la peinture, le modelage, la géométrie et la perspective. La reine Marie de Médicis offrant à Dieu la construction du Val-de-Grâce.] [Cote : Ye 669/Microfilm R 122335] ; [Fig. p.26 : allégories du Temps, de la Mort et de la Peinture (ou Postérité?), putti.] [Cote : Ye 669/Microfilm R 122335]

[Illustrations de Le Decameron] / Titien, dess. et peint.; Bonenfant, grav. ; Jean Boccace, aut. du texte

Comprend : [Portrait en reg. folio I : portrait de l'auteur, Jean Boccace, dessiné par P. Jude et gravé par Bonenfant d'après une peinture de Titien.] Johannes Boccatius. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. folio I : Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. folio xlviii : Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. en reg. folio lxxi : Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. en reg. folio lxxiiii : Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. en reg. folio xcv : Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. avant folio cxv : Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. folio cxxviii : Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. en reg. folio clxvii : Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. en reg. folio ccvii: Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601] ; [Fig. folio ccxxxiiii : Jean Boccace rédigeant son livre.] Bocace. [Cote : Res Y2 402/Microfilm R 1601]

Outcome and prognostic factors in olfactory neuroblastoma: a rare cancer network study.

Purpose: To assess the outcome in patients with olfactory neuroblastoma (ONB). Methods and Materials: Seventy-seven patients treated for nonmetastatic ONB between 1971 and 2004 were included. According to Kadish classification, there were 11 patients with Stage A, 29 with Stage B, and 37 with Stage C. T-classification included 9 patients with T1, 26 with T2, 16 with T3, 15 with T4a, and 11 with T4b tumors. Sixty-eight patients presented with N0 (88%) disease. Results: Most of the patients (n = 56, 73 %) benefited from surgery (S), and total excision was possible in 44 patients (R0 in 32, R1 in 13, R2 in 11). All but five patients benefited from RT, and chemotherapy was given in 21(27%). Median follow-up period was 72 months (range, 6-315). The 5-year overall survival (OS), disease-free survival (DES), locoregional control, and local control were 64%, 57%, 62%, and 70%, respectively. In univariate analyses, favorable factors were Kadish A or B disease, T1 T3 tumors, no nodal involvement, curative surgery, R0/R1 resection, and RT-dose 54 Gy or higher. Multivariate analysis revealed that the best independent factors predicting the outcome were T1 T3, N0, R0/R1 resection, and total RT dose (54 Gy or higher). Conclusion: In this multicenter retrospective study, patients with ONB treated with R0 or R1 surgical resection followed by at least 54-Gy postoperative RT had the best outcome. Novel strategies including concomitant chemotherapy and/or higher dose RT should be prospectively investigated in this rare disease for which local failure remains a problem.

[Illustrations de Kalendarium] / [Non identifié] ; Johann Regiomontanus, aut. du texte

Comprend : [Pl. : calendrier d es éclipses de lune et de soleil de 1475 à 1479.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier d es éclipses de lune et de soleil de 1479 à 1482.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier d es éclipses de lune et de soleil de 1483 à 1487.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier d es éclipses de lune et de soleil de 1487 à 1491.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier d es éclipses de lune et de soleil de 1493 à 1497.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier d es éclipses de lune et de soleil de 1497 à 1504.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier d es éclipses de lune et de soleil de 1505 à 1513.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier d es éclipses de lune et de soleil de 1515 à 1518.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier d es éclipses de lune et de soleil de 1519 à 1523.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier d es éclipses de lune et de soleil de 1523 à 1530.] [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : cadran solaire.] Instrumentum Horarum inaequalium. [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : calendrier lunaire.] Instrumentum veri motus lunae minue. Adde. [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : cadran solaire.] Quadrans Horologii Horizontalis. [Cote : Res g V 57/Microfilm R 16374] ; [Pl. : cadran solaire.] Quadratum Horarium Generale. [Cote : Res g V 57/Microfilm R 16374]

Toxoplasmosis during pregnancy and infancy. A new approach for Switzerland.

In recent years it has become evident that screening for and treatment of acute toxoplasmosis during pregnancy may have no measurable impact on vertical transmission and neonatal morbidity and mortality. A broad lack of evidence with regard to many aspects of congenital toxoplasmosis has been recognised in a common European initiative (EUROTOXO) which reviewed several thousand published papers on the subject of toxoplasmosis during pregnancy and childhood. It was therefore clear that the strategies currently implemented in our country would, on closer inspection, no longer withstand the claim for evidence-based procedures. The arguments and call for a change of paradigm in Switzerland which follow here are the result of a national consensus-finding process involving experts from various specialities, including gynaecology/obstetrics, paediatrics/neonatology, infectiology, ophthalmology and laboratory medicine, together with representatives of the public health authorities.