999 resultados para Modèle des boucles de 1 mb
Resumo:
Welsch (Projektbearbeiter): Satire auf die vorherrschende politische Stimmung in dem als reaktionäre Hochburg geltenden Charlottenburg: Beisele und Eisele geraten kurz nach ihrer Entlassung aus sechswöchiger Untersuchungshaft erneut in die Gefahr einer Festnahme, aus der sie nur ein Berliner Demokrat befreit, indem er die beiden als Vertreter des Abgeordneten Kirchmann bzw. Beauftragten für die Beibehaltung der Institution des Adels ausgibt
Resumo:
Molecular mechanisms that underlie preleukemic myelodysplasia (MDS) and acute myelogenous leukemia (AML) are poorly understood. In MDS or AML with a refractory clinical course, more than 30% of patients have acquired interstitial or complete deletions of chromosome 5. The 5q13.3 chromosomal segment is commonly lost as the result of 5q deletion. Reciprocal and unbalanced translocations of 5q13.3 can also occur as sole anomalies associated with refractory AML or MDS. This study addresses the hypothesis that a critical gene at 5q13.3 functions either as a classical tumor suppressor or as a chromosomal translocation partner and contributes to leukemogenesis. ^ Previous studies from our laboratory delineated a critical region of loss to a 2.5–3.0Mb interval at 5q13.3 between microsatellite markers D5S672 and GATA-P18104. The critical region of loss was later resolved to an interval of approximately 2Mb between the markers D5S672 and D5S2029. I, then generated a long range physical map of yeast artificial chromosomes (YACs) and developed novel sequence tagged sites (STS). To enhance the resolution of this map, bacterial artificial chromosomes (BACs) were used to construct a triply linked contig across a 1 Mb interval. These BACs were used as probes for fluorescent in situ hybridization (FISH) on an AML cell line to define the 5q13.3 critical region. A 200kb BAC, 484a9, spans the translocation breakpoint in this cell line. A novel gene, SSDP2 (single stranded DNA binding protein), is disrupted at the breakpoint because its first four exons are encoded within 140kb of BAC 484a9. This finding suggests that SSDP2 is the critical gene at 5q13.3. ^ In addition, I made an observation that deletions of chromosome 5q13 co-segregate with loss of the chromosome 17p. In some cases the deletions result from unbalanced translocations between 5q13 and 17p13. It was confirmed that the TP53 gene is deleted in patients with 17p loss, and the remaining allele harbors somatic mutation. Thus, the genetic basis for the aggressive clinical course in AML and MDS may be caused by functional cooperation between deletion or disruption of the 5q13.3 critical gene and inactivation of TP53. ^
Resumo:
Magyarhon Örömüdvözlete István Föherczeg, Ö cs. kir. Fensége, Magyarhon' helytartójához = Ungarns Jubelgruß an Se. k.k. Hoheit den durchlauchtigsten Erzherzog Stephan, Statthalter des Königreichs Ungarn
Resumo:
Persönliche Nachrichten, Besuch bei Stoltze, Leopold Sonnemann, Ernst Emmerling, Plan des Kaufs des "Darmstädter Volksblatts"
Resumo:
In allegor. Darstellung
Resumo:
Spottgedicht gegen Papst u. kathol. Kirche, erwähnt wird auch Kloster Gnadenberg
Resumo:
... Christophori Gulielmi Putschii ab Haching Tyrolensis ... ; ... Durch Paulsen Ottenthaler, der freyen Künst Magister, auß hieneben gesetzten Latein, inn Teutsche Rheim trewlich verfasset, Im 1571. Jar
Resumo:
von drey Liebhabern des Lotto-Spiels