Vista de la puerta de entrada de la fortaleza de Xativa [ [Material gráfico]= Vue de la porte d'entrèe de la forteresse de Xativa, et d'une partie de la ville de St. Philippe = View of the great gate of the fortress of Xativa, and of a part of the town of St. Philip

Datos de publicación tomados de la obra a la que pertenece

Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity

Staphylococcus aureus produces a virulence factor, protein A (SpA), that contains five homologous Ig-binding domains. The interactions of SpA with the Fab region of membrane-anchored Igs can stimulate a large fraction of B cells, contributing to lymphocyte clonal selection. To understand the molecular basis for this activity, we have solved the crystal structure of the complex between domain D of SpA and the Fab fragment of a human IgM antibody to 2.7-Å resolution. In the complex, helices II and III of domain D interact with the variable region of the Fab heavy chain (VH) through framework residues, without the involvement of the hypervariable regions implicated in antigen recognition. The contact residues are highly conserved in human VH3 antibodies but not in other families. The contact residues from domain D also are conserved among all SpA Ig-binding domains, suggesting that each could bind in a similar manner. Features of this interaction parallel those reported for staphylococcal enterotoxins that are superantigens for many T cells. The structural homology between Ig VH regions and the T-cell receptor Vβ regions facilitates their comparison, and both types of interactions involve lymphocyte receptor surface remote from the antigen binding site. However, T-cell superantigens reportedly interact through hydrogen bonds with T-cell receptor Vβ backbone atoms in a primary sequence-independent manner, whereas SpA relies on a sequence-restricted conformational binding with residue side chains, suggesting that this common bacterial pathogen has adopted distinct molecular recognition strategies for affecting large sets of B and T lymphocytes.

Memoire pour servir de reponse a l'ecrit des reflections mal et sans fondement refléchiés par les res p[èr]es Jesuistes (sic) du College de Quebec remis pars le R[everen]d J. Duparc superieur dud[it] college a un Ecclesiastique du Seminaire de Quebec le 8 avril 1728 : manuscript, [17--]

Reply to Jean-Baptiste Du Parc's Reflexions sur la contestation survenus entre messieurs du chapitre de Quebec concerning church administration in Quebec.

India & South Asia, 1752 (Image 1 of 2) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte de l'Inde : dressée pour la Compagnie des Indes, par le Sr. d'Anville, Sécrétaire de S.A.S. Mgr. le Duc d'Orleans ; [engraved by] Guill.' de-la-Haye. It was published by Jean Baptiste Bourguignon d'Anville in November 1752. Scale [ca. 1:3,100,000]. This layer is image 1 of 2 total images of the two sheet source map, representing the northern portion of the map. Covers India and portions of South Asia. Map in French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Kalianpur 1975 India Zone III projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, shoreline features, and more. Relief shown pictorially. Includes insets: Negraïs -- Rivière d'Aracan -- Riv. de Sirian -- Archipel de Merghi -- Environs de Junk Selon -- Environs d'Ashem -- Entréé du Gange -- Environs de Goa. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

India & South Asia, 1752 (Image 2 of 2) (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Carte de l'Inde : dressée pour la Compagnie des Indes, par le Sr. d'Anville, Sécrétaire de S.A.S. Mgr. le Duc d'Orleans ; [engraved by] Guill.' de-la-Haye. It was published by Jean Baptiste Bourguignon d'Anville in November 1752. Scale [ca. 1:3,100,000]. This layer is image 2 of 2 total images of the two sheet source map, representing the southern portion of the map. Covers India and portions of South Asia. Map in French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Kalianpur 1975 India Zone III projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, roads, shoreline features, and more. Relief shown pictorially. Includes insets: Negraïs -- Rivière d'Aracan -- Riv. de Sirian -- Archipel de Merghi -- Environs de Junk Selon -- Environs d'Ashem -- Entréé du Gange -- Environs de Goa. This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Southeast Asia, 1742 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Royaume de Siam, avec les royaumes qui luy sont tributaires, et les isles de Sumatra, Andemaon, etc., corrigés selon les observations des six Peres Jesuites ... ; dressé et dedie à Mr. l'abbé de Dangeau par ... le Pere Coronelli, Cosmographe de la Republique de Venisse. It was published by chez Jean Baptiste Nolin in 1742. Scale [ca. 1:4,400,000]. Covers a portion of Southeast Asia including: Indonesia, Malaysia, Thailand, India, Burma, Laos, Cambodia, and Vietnam. Map in French. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM Zone 48N, meters, WGS 1984) projected coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial and administrative boundaries, shoreline features, and more. Relief shown pictorially. Depth shown by sounding. Includes notes.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Map of the Indus River and the neighbouring countries: comprising Sind, parts of Beloochistan and Afghanistan, Cashmeer, Punjab, Bhawulpoor, the protected Sikh States, Bickaneer and Jaysulmeer; & the Western Parts of Rajpootana

compiled by order of Government in the Office of the Surveyor General of India [Geo. Everest] from authentic and recent materials April 1834 by J. Graham ; drawn by Ed. Winston and D. F. Chill.

Martini Azpilcuetæ ... Consiliorum & responsorum, quæ in quinque libros, iuxta numerum & titulos Decretalium, distribuuntur, tomi duo.

Sign.: *6, A-Z6, 2A-2I6, A-Y6, Z8, a-d6, e4

Biological and environmental time series obtained from Point B, Bay of Villefranche

Ecological succession provides a widely accepted description of seasonal changes in phytoplankton and mesozooplankton assemblages in the natural environment, but concurrent changes in smaller (i.e. microbes) and larger (i.e. macroplankton) organisms are not included in the model because plankton ranging from bacteria to jellies are seldom sampled and analyzed simultaneously. Here we studied, for the first time in the aquatic literature, the succession of marine plankton in the whole-plankton assemblage that spanned 5 orders of magnitude in size from microbes to macroplankton predators (not including fish or fish larvae, for which no consistent data were available). Samples were collected in the northwestern Mediterranean Sea (Bay of Villefranche) weekly during 10 months. Simultaneously collected samples were analyzed by flow cytometry, inverse microscopy, FlowCam, and ZooScan. The whole-plankton assemblage underwent sharp reorganizations that corresponded to bottom-up events of vertical mixing in the water-column, and its development was top-down controlled by large gelatinous filter feeders and predators. Based on the results provided by our novel whole-plankton assemblage approach, we propose a new comprehensive conceptual model of the annual plankton succession (i.e. whole plankton model) characterized by both stepwise stacking of four broad trophic communities from early spring through summer, which is a new concept, and progressive replacement of ecological plankton categories within the different trophic communities, as recognised traditionally.