Peregrinación de Juárez : novela histórica mexicana /

Mode of access: Internet.

Código de minería de la República Mexicana con el reglamento para la organización de sus diputaciones y aracel para el cobro de derechos y honorarios.

Mode of access: Internet.

Indicador particular del administrador de hacienda : breve manual, basado sobre reglas de economía rural, inherentes al sistema agrícola en la República mexicana, por J. B. de Dantistéban.

Earlier publication, 1901.

Boletín de la Sociedad de Geografía y Estadística de la República Mexicana.

Title from cover.

Apéndice al Diccionario universal de historia y de geografía. Colección de artículos relativos á la República mexicana ...

Mode of access: Internet.

Revista política de las diversas administraciones que la república Mexicana ha tenido hasta 1873 [i.e. 1837] /

Spine title: Revista política.

Cronica mexicana /

Mode of access: Internet.

Arte mexicana /

"Se reimprime en 1885 bajo el cuidado del Dr. Antonio Peñafiel ..."

Código de colonizacion y terrenos baldíos de la República Mexicana

Mode of access: Internet.

Colección de las leyes fundamentales que han regido en la República Mexicana, y de lo planes que han tenido el mismo caracter desde el año de 1821, hasta el de 1857.

Mode of access: Internet.

Colección legislativa completa de la República Mexicana : con todas las disposiciónes expedidas para la Federación, el Distrito y los territorios federales.

Vol. 34, part l published in 1904 by Eduardo Dublan with same title as the continued title.

Geografía y estadística de la República Mexicana.

t. 1. México.--t. 2. Sinaloa.--t. 3. Veracruz.--t. 4. Nuevo León.--t. 5. Guanajuato.--t. 6. Michoacán.--t. 7. Morelos.--t. 8. Querétaro.--t. 9. Oaxaca.--t. 10. Guerrero.--t. 11. Tlaxcala.--t. 12. Tamaulipas.--t. 13. Durago.--t. 15. Zacatecas.--t. 16. Campeche.--t. 17. Aguascalientes.--t. 18. Colima.--t. 19. Coahuila de Zaragoza.--t. 20. Chiapas.

Boletin de la Sociedad de Geografia y Estadistica de la Republica Mexicana

Mode of access: Internet.

The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis

Resistance to pentavallent antimonial (Sb-v) agents such as sodium stibogluconate (SSG) is creating a major problem in the treatment of visceral leishmaniasis. In the present study the in vivo susceptibilities of Leishmania donovani strains, typed as SSG resistant (strain 200011) or SSG sensitive (strain 200016) on the basis of their responses to a single SSG dose of 300 mg of Sb-v/kg of body weight, to other antileishmanial drugs were determined. In addition, the role of glutathione in SSG resistance was investigated by determining the influence on SSG treatment of concomitant treatment with a nonionic surfactant vesicle formulation of buthionine sulfoximine (BSO), a specific inhibitor of the enzyme gamma-glutamylcysteine synthetase which is involved in glutathione biosynthesis, and SSG, on the efficacy of SSG treatment. L. donovani strains that were SSG resistant (strain 200011) and SSG sensitive (strain 200016) were equally susceptible to in vivo treatment with miltefosine, paromomycin and amphotericin B (Fungizone and AmBisome) formulations. Combined treatment with SSG and vesicular BSO significantly increased the in vivo efficacy of SSG against both the 200011 and the 200016 L. donovani strains. However, joint treatment that included high SSG doses was unexpectedly associated with toxicity. Measurement of glutathione levels in the spleens and livers of treated mice showed that the ability of the combined therapy to inhibit glutathione levels was also dependent on the SSG dose used and that the combined treatment exhibited organ-dependent effects. The SSG resistance exhibited by the L. donovani strains was not associated with cross-resistance to other classes of compounds and could be reversed by treatment with an inhibitor of glutathione biosynthesis, indicating that clinical resistance to antimonial drugs should not affect the antileishmanial efficacies of alternative drugs. In addition, it should be possible to identify a treatment regimen that could reverse antimony resistance.

The effect of climate change on the potential distribution of the European Phlebotomus species and the parasite Leishmania infantum in 2011-2070. A climate envelope modeling approach

Aims: In the Mediterranean areas of Europe, leishmanisasis is one of the most emerging vector-borne diseases. Members of genus Phlebotomus are the primary vectors of the genus Leishmania. To track the human health effect of climate change it is a very important interdisciplinary question to study whether the climatic requirements and geographical distribution of the vectors of human pathogen organisms correlate with each other. Our study intended to explore the potential effects of ongoing climate change, in particular through a potential upward altitudinal and latitudinal shift of the distribution of the parasite Leishmania infantum, its vectors Phlebotomus ariasi, P. neglectus, P. perfiliewi, P. perniciosus, and P. tobbi, and some other sandfly species: P. papatasi, P. sergenti, and P. similis. Methods: By using a climate envelope modelling (CEM) method we modelled the current and future (2011-2070) potential distribution of 8 European sandfly species and L. infantum based on the current distribution using the REMO regional climate model. Results: We found that by the end of the 2060’s most parts of Western Europe can be colonized by sandfly species, mostly by P. ariasi and P. pernicosus. P. ariasi showed the greatest potential northward expansion. For all the studied vectors of L. infantum the entire Mediterranean Basin and South-Eastern Europe seemed to be suitable. L. infantum can affect the Eastern Mediterranean, without notable northward expansion. Our model resulted 1 to 2 months prolongation of the potentially active period of P. neglectus P. papatasi and P. perniciosus for the 2060’s in Southern Hungary. Conclusion: Our findings confirm the concerns that leishmanisais can become a real hazard for the major part of the European population to the end of the 21th century and the Carpathian Basin is a particularly vulnerable area.