Trends in diabetes incidence from 1992 to 2015 and projections for 2024: A Portuguese General Practitioner’s Network study

Background: Diabetes is known as a major cause of morbidity and mortality worldwide. Portugal is known as the European country with the highest prevalence of this disease. While diabetes prevalence data is updated annually in Portugal, the General Practitioner’s (GP) Sentinel Network represents the only data source on diabetes incidence. This study describes the trends in Diabetes incidence, between 1992 and 2015, and estimate projections for the future incidence rates in Portugal until 2024. Methods: An ecological time-series study was conducted using data from GP Sentinel Network between 1992 and 2015. Family doctors reported all new cases of Diabetes in their patients’ lists. Annual trends were estimated through Poisson regression models as well as the future incidence rates (until 2024), sex and age group stratified. Incidence rate projections were adjusted to the distribution of the resident Portuguese population given Statistics Portugal projections. Results: The average increase in Diabetes incidence rate was in total 4.29% (CI95% 3.80–4.80) per year under study. Until 1998–2000, the annual incidence rate was higher in women, and from 1998–2000 to 2013–2015 turn out to be higher in men. The incidence rate projected for 2022–2024 was 972.77/105 inhabitants in total, and 846.74/105 and 1114.42/105, respectively, in women and men. Conclusions: This is the first study in Portugal to estimate diabetes incidence rate projections. The disturbing reported projections seem realistic if things continue as in the past. Actually, effective public health policies will need to be undertaken to minimize this alarming future scenario.

Recommendations for Genetic Testing to Reduce the Incidence of Anthracycline-induced Cardiotoxicity

AIM Anthracycline-induced cardiotoxicity (ACT) occurs in 57% of treated patients and remains an important limitation of anthracycline-based chemotherapy. In various genetic association studies, potential genetic risk markers for ACT have been identified. Therefore, we developed evidence-based clinical practice recommendations for pharmacogenomic testing to further individualize therapy based on ACT risk. METHODS We followed a standard guideline development process; including a systematic literature search, evidence synthesis and critical appraisal, and the development of clinical practice recommendations with an international expert group. RESULTS RARG rs2229774, SLC28A3 rs7853758 and UGT1A6 rs17863783 variants currently have the strongest and the most consistent evidence for association with ACT. Genetic variants in ABCC1, ABCC2, ABCC5, ABCB1, ABCB4, CBR3, RAC2, NCF4, CYBA, GSTP1, CAT, SULT2B1, POR, HAS3, SLC22A7, SCL22A17, HFE and NOS3 have also been associated with ACT, but require additional validation. We recommend pharmacogenomic testing for the RARG rs2229774 (S427L), SLC28A3 rs7853758 (L461L) and UGT1A6*4 rs17863783 (V209V) variants in childhood cancer patients with an indication for doxorubicin or daunorubicin therapy (Level B - moderate). Based on an overall risk stratification, taking into account genetic and clinical risk factors, we recommend a number of management options including increased frequency of echocardiogram monitoring, follow-up, as well as therapeutic options within the current standard of clinical practice. CONCLUSIONS Existing evidence demonstrates that genetic factors have the potential to improve the discrimination between individuals at higher and lower risk of ACT. Genetic testing may therefore support both patient care decisions and evidence development for an improved prevention of ACT.

Housing discrimination study : incidence of discrimination and variation in discriminatory behavior /

"Contract HC-5811."

Housing discrimination study : incidence and severity of unfavorable treatment /

"HUD-1327-PDR"--Cover p. 4.

The incidence of drugs in fatally injured drivers. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

The relationship of solid waste storage practices in the inner city to the incidence of rat infestation and fires /

"A current report on solid waste management"--Cover.

Model for determining the incidence of unemployment among offenders.

Mode of access: Internet.

The incidence and role of drugs in fatally injured drivers. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Disclosures on a precipitation indicator, moisture detector, vacuum ball valve, film strip printer, normal incidence interferometer, color sorter, and coaxial T. /

Mode of access: Internet.

Back scattering of a plane electromagnetic wave from an infinite cylinder of plasma with small axial gradients and arbitrary radial gradients of electron density : normal incidence /

"Prepared under contract no. NOrd 18053."

The incidence of abnormal loading in residential buildings /

"Supersedes NBSIR 76-1048."

Annual cancer incidence by cancer type, sex, and race Illinois, 1986-1993 /

"April 1995."

Cancer incidence in community areas of Chicago, Illinois, 1987-1991 /

Mode of access: Internet.

Cancer incidence and age at Northern migration of African Americans in Illinois, 1986-1991 /

"April 1997."

Cancer incidence by community area, Chicago, Illinois, 1986-1989.

"December 1991."