[Archives de la Parole]. , Parable of the prodigal son : in Hō / [Sir George Grierson], éd. ; Linguistic survey of India ; Voix parlée

[Traditions. Asie. Inde. Chotā Nāgpur]

[Archives de la Parole]. , Parable of the prodigal son : in Santali / [Sir George Grierson], éd. ; Linguistic survey of India ; Voix parlée

[Traditions. Asie. Inde. Chotā Nāgpur]

[Archives de la Parole]. , Parable of the prodigal son : in Kurukh - Dravidien - Linguistic survey of India / [Sir George Grierson], éd. ; Linguistic survey of India ; Voix parlée, homme

[Traditions. Asie. Inde. Chotā Nāgpur]

[Archives de la Parole]. , Parable of the prodigal son in Chhattīsgaṛhī Hindī / [Sir George Grierson], éd. ; Linguistic survey of India ; [Mr. Ramanand, B.A., LL.B], voix

[Traditions. Asie. Inde. Madhya Pradesh. Chhattisgarh]

[Archives de la Parole]. , Parable of the Prodigal Son : in Kolami, from Yeotmal (Berar) - Dravidien - Ling[uistic] survey of India / [Sir George Grierson], éd. ; Linguistic survey of India ; [Rakma Kōlām], voix

[Traditions. Asie. Inde. Madhya Pradesh. Maharashtra]

[Archives de la Parole]. , Parable of the prodigal son in Kanarese : [from Dharwar] / [Sir George Grierson], éd. ; Linguistic survey of India ; [G.G. Kulkarni], voix

[Traditions. Asie. Inde. Etat du Karnataka. Dharwad]

[Archives de la Parole]. , [Parable of the prodigal son in Gujarātī] / [Sir George Grierson], éd. ; Linguistic survey of India ; [Someshvar Dhirajram], voix

[Traditions. Asie. Inde. État du Gujarat. Ahmadabad]

A novel dominant mutation of the Nav1.4 alpha-subunit domain I leading to sodium channel myotonia.

BACKGROUND: Mutations in SCN4A may lead to myotonia. METHODS: Presentation of a large family with myotonia, including molecular studies and patch clamp experiments using human embryonic kidney 293 cells expressing wild-type and mutated channels. RESULTS: In a large family with historic data on seven generations and a clear phenotype, including myotonia at movement onset, with worsening by cold temperature, pregnancy, mental stress, and especially after rest after intense physical activity, but without weakness, the phenotype was linked with the muscle sodium channel gene (SCN4A) locus, in which a novel p.I141V mutation was found. This modification is located within the first transmembrane segment of domain I of the Na(v)1.4 alpha subunit, a region where no mutation has been reported so far. Patch clamp experiments revealed a mutation-induced hyperpolarizing shift (-12.9 mV) of the voltage dependence of activation, leading to a significant increase (approximately twofold) of the window current amplitude. In addition, the mutation shifted the voltage dependence of slow inactivation by -8.7 mV and accelerated the entry to this state. CONCLUSIONS: We propose that the gain-of-function alteration in activation leads to the observed myotonic phenotype, whereas the enhanced slow inactivation may prevent depolarization-induced paralysis.

Proposed Improvement of the Iowa State Capitol Grounds, An Address before the Iowa Chapter American Institute of Architects at the State Historical Buiding, Des Moines, Iowa, October 22, 1913.

Concerning improvements to the State Capitol Grounds including placement of the Allison memorial and Soldiers and Sailor's momuments; removal of heating plant and relieving the state of coal, ashes, gas and smoke; provision of office space to the Adjutant General; an eventual executive mansion; provision of office buildings; and for a Supreme Court building where together with its library auxiliaries will have perpetual growth and constant accessbility; and propose restoration of natural scenic value of the capitol site.

Annual Report of the Hawk-i Board to the Governor, 2007

Annual Report of the hawk-i Board to the Governor

Annual Report of the Hawk-i Board to the Governor, 2008

Annual Report of the hawk-i Board to the Governor

Annual Report of the Hawk-i Board to the Governor, 2010

Annual Report of the hawk-i Board to the Governor

Annual Report of the Hawk-i Board to the Governor, 2009

Annual Report of the hawk-i Board to the Governor

The prognostic value of semi-quantitative i-123 mibg scintigraphy at diagnosis in high risk neuroblastoma: validation of the siopen score method

Purpose: SIOPEN scoring of 123I mIBG imaging has been shown to predict response to induction chemotherapy and outcome at diagnosis in children with HRN.Method: Patterns of skeletal 123I mIBG uptake were assigned numerical scores (Mscore) ranging from 0 (no metastasis) to 72 (diffuse metastases) within 12 body areas as described previously. 271 anonymised, paired image data sets acquired at diagnosis and on completion of Rapid COJEC induction chemotherapy were reviewed, constituting a representative sample of 1602 children treated prospectively within the HR-NBL1/SIOPEN trial. Pre-and post-treatment Mscores were compared with bone marrow cytology (BM) and 3 year event free survival (EFS).Results: Results 224/271 patients showed skeletal MIBG-uptake at diagnosis and were evaluable forMIBG-response. Complete response (CR) on MIBG to Rapid COJEC induction was achieved by 66%, 34% and 15% of patients who had pre-treatment Mscores of <18 (n¼65, 29%), 18-44 (n¼95,42%) and Y ´ 45 (n¼64, 28.5%) respectively (chi squared test p<.0001). Mscore at diagnosis and on completion of Rapid COJEC correlated strongly with BM involvement (p<0.0001). The correlation of pre score with post scores and response was highly significant (p<0.001). Most importantly, the 3 year EFS in 47 children with Mscore 0 at diagnosis was 0.68 (A ` 0.07), by comparison with 0.42 (A` 0.06), 0.35 (A` 0.05) and 0.25 (A` 0.06) for patients in pre-treatment score groups <18, 18-44 and Y ´ 45, respectively (p<0.001). AnMscore threshold ofY ´ 45 at diagnosis was associated with significantly worse outcome by comparison with all other Mscore groups (p¼0.029). The 3 year EFS of 0.53 (A` 0.07) of patients in metastatic CR (mIBG and BM) after Rapid Cojec (33%) is clearly superior to patients not achieving metastatic CR (0.24 (A ` 0.04), p¼0.005).Conclusion: SIOPEN scoring of 123I mIBG imaging has been shown to predict response to induction chemotherapy and outcome at diagnosis in children with HRN.

Burials of the Algonquian, Siouan and Caddoan tribes West of the Mississippi / by David I. Bushnell, jr.

Collection : Bulletin ; 83