986 resultados para Er ya.


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Relevo en la dirección de la revista

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Written in one column, 9 lines per page, in black.

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Written in one column, 21 lines per page, in black ink with words and sentences underlined in red.

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بسم الله الرحمن الرحيم هذا كتاب تسطيح الاصطرلاب من انشاء المولى ... :Incipit

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Written in one column, 27 lines per pages, in black and red.

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Bound with ʻAlī ibn al-Ḥasan ibn ʻAsākir, Kitāb al-Arbaʻīn al-buldānīyah, and other hadith collections.

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Tese de mestrado, Biologia Molecular e Genética, Universidade de Lisboa, Faculdade de Ciências, 2016

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Rhomboid intramembrane proteases are the enzymes that release active epidermal growth factor receptor (EGFR) ligands in Drosophila and C. elegans, but little is known about their functions in mammals. Here we show that the mammalian rhomboid protease RHBDL4 (also known as Rhbdd1) promotes trafficking of several membrane proteins, including the EGFR ligand TGFα, from the endoplasmic reticulum (ER) to the Golgi apparatus, thereby triggering their secretion by extracellular microvesicles. Our data also demonstrate that RHBDL4-dependent trafficking control is regulated by G-protein coupled receptors, suggesting a role for this rhomboid protease in pathological conditions, including EGFR signaling. We propose that RHBDL4 reorganizes trafficking events within the early secretory pathway in response to GPCR signaling. Our work identifies RHBDL4 as a rheostat that tunes secretion dynamics and abundance of specific membrane protein cargoes.

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"Conclusiones aprobadas por el Congreso en la sesión del 8 de abril de 1895."