Melhorias dos processos no setor de expedição em uma transportadora de cargas fracionadas

The transport market has forced organizations reduce the cost of services and processes, resulting from the highly competitive and, for such waste at all levels and processes are a focus of study for its elimination. This study refers to carrier fractional loads, located in the municipality of Itapecerica da Serra Layout and headquartered in São Paulo, which requires a rapid development throughout its structure, because its expansion was not accompanied by an evolution of effective processes. The need to increase efficiency in delivery with a reduced cost of transport forced the company to hire a logistics consulting to help identify potential bottlenecks in processes, suggest improvements with greater impact and implementation at the end of a critical analysis of results. This work focuses on the Layout of the warehouse shipping area of this organization and we used the method of action research to the consultant and involved could reach this conclusion collaboratively, as well as interviews with those involved in the process and also visual observation. Tools such as Key Performance Indicator, Mapping Workflow, Analytic Hierarchy Process, Applied Statistics and Standard Operating Procedure were used to assist in the identification, analysis and implementation of the proposed improvements

Avaliação do desempenho ambiental da produção canavieira com colheita mecanizada: contribuição à implantação de um sistema simplificado de gestão ambiental da propriedade

The consuming of the natural resources in the agricultural sector does not represent only one external factor of the productive process, but also it implies in a bigger cost for the production, justified for this environmental degradation. In view of the necessity of evaluating the sustainment of the agricultural businesses, the use of performance indicators if makes of extreme importance. The measurement of the support through environmentalindicators is one of the most accepted forms of performing the evaluation of one given agricultural activity. In this context, the Base System for Eco-certification of Agricultural Businesses (Eco-cert Rural) developed by the Embrapa Environment at Jaguariúna/SP, has for purpose to present a method of evaluation of the agricultural businesses, not only of the point of view of the ecological performance, as well as considering the social, economic and organizational aspects. Through the analysis of the performance of the activity and the regularization of the disconformities found, it makes possible the eco-certification of the activities in the varied existing protocols, offering technologies designed to the sustainable development of the agricultural businesses. Using Eco-cert.Rural, this work evaluated the contribution of the use of mechanized harvest in sugar cane handling, front to the traditional system of manual harvest, using the fire. In the Sugar Cane Activity General Performance Index, Agrícola Rio Claro scored 2,08 of a maximum of 15. Amongst all the indicators, those wich reached performance worse had been related to the Use of Energy and the Income, by increasing fossil fuel consumptiom, and implying income concentration due to resignations of rural workers. However, the improvements on the environment quality by supressing manual harvest through fire are very significant. Beyond the great reduction in...(Complete abstract click electronic access below)

Importância da avaliação de hematúrias através do dismorfismo eritrocitário

A hematúria é a eliminação de um número anormal de hemácias na urina e suas causas são múltiplas e nem sempre a investigação clínica é simples. A indicação para se estabelecer a diferenciação entre as causas das hematúrias, se glomerulares ou não glomerulares é feita através de solicitação específica do exame de dismorfismo eritrocitário. Esse exame é realizado em urina recém emitida, colhida em jato médio, por meio de microscopia de contraste de fase onde a morfologia das hemácias pode sugerir a origem da hematúria, direcionando o diagnóstico e conduta terapêutica pelo clínico. Neste projeto estudou-se a aplicação da caracterização das hemácias por microscopia de contraste de fase nos casos de hematúrias detectadas, sem a presença de leucocitúrias (sinais que sugerem infecção do trato urinário) nos achados de sedimentoscopia urinária realizados na rotina do setor de bioquímica clínica do CRD-Nac-UNESP, avaliando assim a importância da indicação da aplicação deste procedimento para a clínica

Condições mínimas para o encerramento de áreas que abrigaram resíduos sólidos domiciliares

In 2010 Brazil produced about 60.8 million of municipal solid waste, an amount 6.8% higher than in 2009 and six times the rate of urban population growth recorded in the same period. According to a study by the Brazilian Association of Companies of Special Wasteand Public Cleansing (Abrelpe), the average waste generated per person in the same period the country was 378 Kilograms, an amount 5.3% higher to 2009 (359 Kg). The total reached 60.8 milion tons of waste, 6.5 million tons were collected and not end up inrivers, streams and vacant lots. Of this total production, 42.4% or 22.9 million Tons, did not receive proper destination and destiny had dumps and landfills. The data show that the country is in upward trend in waste generation, but did not advance the appropriate destination at the same pace. The waste thus throw open cause public helth problems, such as proliferation of disease vectors (flies, mosquitoes, cockroaches, rats, and others). Generation of odors and especially the pollution of soil, surface water and groundwater through slurry ( liquid black, smelly and high pollution potential produced by the decomposition of organic matter contained in waste), affecting the water. This Study shows the popper closure of the areas, wich long has been degrading our natural resources, not to cause damage to nature and therefore society

Geração de vacinas antitumorais de células dendríticas humanas sensibilizadas com RNA de células tumorais pré-tratadas com agentes antineoplásicos

O câncer colorretal (CCR) é a terceira causa mais comum de câncer no mundo em ambos os sexos e a segunda causa em países desenvolvidos. Seu tratamento convencional é baseado na cirurgia associada à radioterapia e à quimioterapia em dose máxima tolerável, para tentativa de eliminação massiva das células tumorais. Tal abordagem, no entanto, pode causar efeitos colaterais importantes, entre eles as alterações hematopoiéticas e a supressão da resposta imune. As vacinas de células dendríticas mostram-se como opção terapêutica promissora para muitos tipos de câncer, havendo diferentes protocolos de preparação e sensibilização dessas células para dirigir a resposta antitumoral específica. Alguns agentes antineoplásicos em doses ultrabaixas mostraram modular positivamente as células dendríticas (DCs) e, na célula tumoral, promover alterações na transcrição de vários genes imunologicamente relevantes. Considerando que, em estudos prévios, tais mudanças transcricionais resultaram em aumento de imunogenicidade das células tumorais, hipotetizamos que o RNA das células pré-tratadas deve ser mais eficiente do que o RNA das células originais para preparação de vacinas de células dendríticas. Assim, objetivamos avaliar se o tratamento de células do tumor de cólon humano (HT-29) com PAC ou 5-FU/LEUCO torna seu RNA mais eficiente para preparação dessas vacinas. Para essa investigação, DCs humanas geradas a partir de monócitos de sangue periférico foram transfectadas com RNA total das células tumorais pré-tratadas e, a seguir, testadas quanto à capacidade de apresentação de antígenos e indução de células T citolíticas específicas. Apesar da baixa viabilidade celular pós eletroporação, os resultados obtidos sugerem que o tratamento de células tumorais com concentrações não tóxicas de 5-FU ou PAC promove alteração de expressão... (Resumo completo, clicar acesso eletrônico abaixo)

Analise de defeitos em motores através de vibração mecânica: estudo de caso

Revolving machines are among the most used equipment in general industry and therefore expenditures on this equipment class are a significant portion of the total amount spent by the company. If there is an unscheduled stop of some of this equipment, industrial plants can lose huge amounts of money caused by interrupted production and parts delay. Others may increase significantly maintenance costs due to consequences elsewhere not affected before. Even plant and people safety can be in danger if there is an operation interruption without a backup system start. This work is focused on a rotating system case study which is monitored by vibration analysis that shows that is possible to determine when is the most appropriate time for equipment intervention without any reliability loss just by using a simple and cheap system which is not much used because professionals are not aware to its utility. Industrial facilities were evaluated by fail detection and historical analysis in some equipment in order to show feasibility of vibration analysis through a before-during-after process. The plant evaluated is part of a chemical multinational located in Guaratinguetá-SP. At this time, that plant had around 650 critical equipment monthly monitored and no unscheduled shutdown was registered in one year period due to equipment monitoring

Gerenciamento dos resíduos de serviços de saúde do pronto socorro de um hospital escola na cidade de Botucatu

Health Care Waste (HCW) represents 1%, and it has presently gained a lot of importance. Adequate management is one of the great challenges to be faced by health care centers. It has gained distinction and been widely discussed by members of the sectors involved with sanitation, public health and environmental issues due to waste physical, chemical biological characteristics, which pose potential risk to the environment and public health. The present study aims at evaluating HCW internal management by following all its phases, determining indicators, classifying and quantifying, establishing production rates (kg /patient/day) for the sector and designing materials to disseminate appropriate HCW disposal in the Emergency Room of the UNESP University Hospital in the city of Botucatu according to the guidelines presently in force. : From June to October 2011, the waste flow was observed from its production to final disposal. Four weight measurements were performed on four consecutive days in the month of August by using a properly calibrated (in grams) digital scale at the times scheduled for collection of the produced waste. Hence, the daily and monthly amounts were estimated according to their classification. All the waste packaged in the bags in garbage cans in the Emergency Room for a 24-hour period was considered to be a sample. Separation was not adequately performed in that sector, and waste from Group A was mixed with that from Group D. The amount of infectious waste produced in the sector corresponded to 87.80 %, common waste to 10.93 % and recyclable waste to 1.27%. The mean daily HCW production was of 123.300 kg/day, and the total monthly production was of 3,822 kg/month, which was distributed as follows: Group A 3,355,750 kg/month; Group D 417,570 kg/month and recyclables 48,670 kg/month. The production rate corresponded to 0.47 kg/patient/day, thus showing... (Complete abstract click electronic access below)

Diagnóstico dos resíduos de construção e demolição: uma contribuição à elaboração e implantação da gestão integrada dos RCD no município de Guaratinguetá – SP

The problem of solid waste has caused discussions about the huge amount that is generated in Brazilian cities, in particular the waste from construction and demolition (CDW), called spoil. In many cases these wastes are disposed of improperly and even criminally in urban areas, causing serious economic, social and environmental problems. Due to the lack of public policies and appropriate management of such waste came up with the CONAMA, in its resolution nº 307 of 2002, the obligation of municipalities in deploy the integrated management of construction and demolition wastes for the resolution of problems caused by inadequate management and disposal of such waste. By following a methodology suggested by Pinto & González (2005), with adaptations of other authors, it is proposed in this work the lifting of a diagnosis of the CDW in the municipality of Guaratinguetá-SP, through theoretical analysis and field research, with purpose to guide the public servants in the elaboration and implementation of integrated management. The results must contain information necessary for that end, such as the knowledge of generators, agents, collectors and transporters, disposition areas and the disposal of waste

Estudo sobre a condição de coleta e tratamento de esgoto sanitário do município de Ubatuba-SP

The actual work broaches a study about the collection and treatment of sanitary sewage from the municipality of Ubatuba in its operational aspects and the tariff policy from the service. Themes related to the subject like the history of collection and treatment of sewage, its development in Brazil and its importance for public health and environmental preservation, as well as historical and geographical aspects of Ubatuba/SP, are present in the literature review. The methodology consists in guided visit in the colletion and treatment of sewage facilities and interview with technical managers. With the technical data obtained, it is made a discussion of the results and possible recommendations

Platinosomíase em felinos domésticos: um diferencial para obstrução biliar

The platinosomiase is a disease the hepatobiliary system of domestic felines being caused by trematode Platynosomum fastosum. The life cycle of the parasite includes the presence of three intermediate hosts (snails, terrestrial isopodes, lizards or frogs). The cat is considered definitive host of the parasite and acquires the infection eating a vertebrate intermediate host containing metacercariae. The adult parasites generally inhabit the liver, gallbladder and bile ducts of cats. The severity of clinical manifestations depends mainly on the number of flukes in the biliary tract. Many animals are asymptomatic or exhibit nonspecific clinical manifestations such as anorexia, lethargy, weight loss, vomiting and diarrhea. In large infestations can occur biliary obstruction resulting in jaundice, cirrhosis, hepatitis cholangiohepatitis and even death. The definitive diagnosis is accomplished through by the detection of fluke eggs in feces or through laparotomy and liver biopsy. Treatment should be based on the use of anthelmintic for the elimination of the parasite and supportive therapy for the animal. Prevention is difficult due to predatory nature of the cat. The control can be accomplished through periodic fecal examinations

Bancos de capacitores se corrente de Inrush

This work discusses about the effects and methods of control and elimination of the currents transients generated by switching capacitor banks, this currents are called inrush currents. Capacitor banks are widely used to compensate a low power factor generated by the widespread use of inductive loads. Currently many of these banks are automatic and therefore the capacitive cells are connected and disconnected according to the inductive loads on the network. However when connecting a capacitor bank to a bus can generate currents transients generated by electromagnetic transients. Aspects of the network, for example, the existence of a bank already connected to the bus, can influence the intensity of this phenomenon. This paper discusses some characteristics of the capacitors and the network to justify and explain the appearance of these transients and discusses its effects on the network and to other equipment. It is concluded that the main cause of this phenomenon is the voltage difference between the capacitor to be connected to the network and the bus, the results of the study were the bases to discuss the traditional methods to mitigate these currents and therefore its negative effects. Although in this paper is yet developed a method of electronic switching that can greatly reduce these transients

Análise dos efeitos do fipronil (ingrediente ativo do Frontline) nas células das glândulas salivares de fêmeas de Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae)

O presente estudo analisou os efeitos da substância química fipronil, ingrediente ativo do Frontline® (acaricida e inseticida), nas glândulas salivares de fêmeas em jejum e semi-ingurgitadas de carrapatos Rhipicephalus sanguineus. As fêmeas em jejum foram expostas apenas à concentração de 1ppm do composto e as semi-ingurgitadas foram expostas a três concentrações de 1ppm, 5ppm e 10ppm (foi utilizada água destilada como controle). Os resultados histológicos e histoquímicos revelaram ação significativa desse composto, alterando morfofisiologicamente o tecido glandular dos indivíduos em jejum e semiingurgitados. Nas fêmeas em jejum, verificaram-se mudanças morfológicas nos ácinos do tipo I, como aumento do tamanho e do diâmetro do seu lúmen. Estas mudanças, provavelmente, estejam relacionadas à função excretora, apontando para os ácinos I como sendo os responsáveis pela eliminação do sistema deste xenobiótico ao qual o parasita foi exposto. Naquelas semi-ingurgitadas, o composto não interferiu no processo de morte que, nestes indivíduos, é por meio de apoptose. Nas fêmeas semi, no entanto, o fipronil acelerou o processo de degeneração das glândulas salivares, que se intensificou (danos mais acentuados) à medida que aumentaram as concentrações do produto. Os dados aqui apresentados deixaram clara a interferência dessa substância no processo de ingurgitamento das fêmeas de R. sanguineus, o que conseqüentemente poderia refletir no seu processo reprodutivo, diminuindo ou mesmo cessando a postura de ovos e provocando menores perdas de sangue nos hospedeiros, reduzindo assim, a transmissão de patógenos veiculados por estas glândulas.

Avaliação da influência da esterilização por radiação gama nas propriedades mecânicas, estruturais e na biocompatibilidade de matrizes híbridas orgânico-inorgânicas

Atualmente, as pesquisas acadêmicas e industriais não estão voltadas apenas para a descoberta de novos fármacos, mas também para novas maneiras de administração de medicamentos pretendendo obter melhores ações farmacológicas alem de reduzir efeitos colaterais. Partindo deste pressuposto, estudos demonstram que inúmeras moléculas podem ser incorporadas a polímeros híbridos orgânico-inorgânico preparados pelo processo sol-gel, assim pretende-se estudar a possibilidade de sua aplicação no desenvolvimento de um dispositivo de liberação controlada de fármacos na forma de implantes subcutâneos. As matrizes hibridas para serem implantadas devem, necessariamente, ser estéreis. Para isto este trabalho analisa a interação entre o processo de esterilização e uma provável alteração estrutural nestes polímeros. A esterilização por calor úmido em autoclave e a esterilização por radiação gama foram escolhidas para analisar a correlação entre alteração estrutural do hibrido e o processo de eliminação de microorganismos. Outro aspecto que levamos em consideração foi a melhora das características mecânicas das matrizes poliméricas confeccionadas com poli óxido etileno de peso molecular 1900 (POE 1900) e poli óxido propileno de peso molecular 400 (POP 400). Para serem implantadas estas matrizes devem estar uniformes, e não podem trincar ou quebrar antes ou após a implantação. Considerando estes fatores foi adicionado as amostras um agente plastificante, o álcool polivinílico (PVA), na tentativa de melhorar estas características

Propriedades estruturais de géis de sílica preparados com adições de dodecil sulfato de sódio

This work aims to study the structural characteristics of silica gels obtained from the acid hydrolysis of tetraethoxysilane (TEOS) in water solutions with different concentrations of sodium dodecyl sulfate (SDS). The structural characteristics were studied in stages ranging from the wet gel to the dry stages of the gels (aerogels and xerogels). Aerogels were obtained by ambient pressure drying (APD) after silylation process using trimethylchlorosilane (TMCS) as silylating agent. Xerogels were obtained by conventional evaporating the liquid phase from non silylated gels. The samples were characterized by nitrogen adsorption and small angle X-ray scattering (SAXS). The structure of the wet gels and of the aerogels prepared with the surfactant exhibited characteristics of mass-fractal structures with fractal dimension D in the range 2.1-2.2 for the wet gels and 2.3-2.4 for the aerogels. The characteristic size  of the fractal domain reduces while the size a0 of the primary silica particle composing the fractal structure increases with the drying of the gels, in a process in which share of the porosity is eliminated. Aerogels exhibited typical values for the specific surface of 900 m2g-1 and of 3.5 cm3.g-1 for the total pore volume. These values are correspondingly comparable to those of the aerogels prepared by supercritical drying, since the silylation process replaces hydrophilic –OH groups by hydrophobic –Si-R3 ones, inhibiting the porosity elimination on drying. The silica particle size also increases lightly with the silylation because the attachment of the –Si-R3 groups on the silica surface. The pore size distribution curves of the aerogels are similar for all samples exhibiting a maximum in around 40 nm, independent the concentration of surfactant. This suggests that the characteristic size of 40 nm is due to the association of surfactant micelles... (Complete abstract click electronic access below)

O Sistema de Gestão Ambiental e sua contribuição socioambiental para a biblioteca central da UNESP, Campus Rio Claro/SP

The minimization and mitigation of environmental impacts caused by the activities of organizations is increasingly becoming a key concern due to factors such as market demand, including suppliers and consumer markets, quality standards and even marketing strategies. The implementation of an EMS - Environmental Management System - allows the organization to achieve the level of environmental performance for its determined and promotes continuous improvement over time. This system consists of a schedule of activities, so as to eliminate or minimize impacts to the environment through preventive actions. It also provides a structured approach to set and achieve goals and objectives, and to establish procedures, work instructions and control, ensuring that the implementation of the policy can become reality. The objective of this work consists in planning a system using environmental management based on the ISO 14001 - standard internationally more widespread and accepted in the requirements to establish and operate an EMS - the Central Library, UNESP, Rio Claro / SP to stimulate the quest for continuous improvement and sustainability in the educational institution. For making the diagnosis of this planning was used the PDCA methodology, suggested by the standard, as well as all requirements for compliance. The results show that the benefits that the organization will receive involve reducing expenses and cost of energy and water, and improve the organization's reputation before the whole university and other educational institutions, reaching about three thousand people on university