The Optimality of Decision Making During Motor Learning

In our daily lives, we often must predict how well we are going to perform in the future based on an evaluation of our current performance and an assessment of how much we will improve with practice. Such predictions can be used to decide whether to invest our time and energy in learning and, if we opt to invest, what rewards we may gain. This thesis investigated whether people are capable of tracking their own learning (i.e. current and future motor ability) and exploiting that information to make decisions related to task reward. In experiment one, participants performed a target aiming task under a visuomotor rotation such that they initially missed the target but gradually improved. After briefly practicing the task, they were asked to select rewards for hits and misses applied to subsequent performance in the task, where selecting a higher reward for hits came at a cost of receiving a lower reward for misses. We found that participants made decisions that were in the direction of optimal and therefore demonstrated knowledge of future task performance. In experiment two, participants learned a novel target aiming task in which they were rewarded for target hits. Every five trials, they could choose a target size which varied inversely with reward value. Although participants’ decisions deviated from optimal, a model suggested that they took into account both past performance, and predicted future performance, when making their decisions. Together, these experiments suggest that people are capable of tracking their own learning and using that information to make sensible decisions related to reward maximization.

Towards a Fragmented Neighbourhood: Policies of the EU and Russia and their consequences for the area that lies in between. CEPS Essay No. 17, 17 October 2014

In the current volatile climate, the EU needs a strategy towards Russia that goes beyond sanctions. In reviewing the European Neighbourhood Policy and the Eastern Partnership, the EU’s incoming leadership should be more sensitive towards the existing political, diplomatic, economic, energy and military ties between Russia and the countries in the common neighbourhood. After all, it is by exploiting these ties that Russia was able to turn this neighbourhood into an area of destructive competition − the primary victim of which is Ukraine. Understanding Russia’s perceptions and being sensitive to these longstanding ties does not mean justifying their use by the Kremlin. Nevertheless, factoring these ties into the EU’s policies vis-à-vis its Eastern neighbourhood is a prerequisite for more reflective, responsive and effective EU policies.

Analysing the Contribution of Business Services to European Economic Growth. Bruges European Economic Research (BEER) Papers 9/February 2007

The sector business services contributes directly and indirectly to aggregate economic growth in Europe. The direct contribution comes from the sector’s own dynamism. Though the business-services industry appears to be characterised by strong cyclical volatility, there was also a strong structural growth. Business services actually generated more than half of total net employment growth in the European Union since the second half of the 1990s. Apart from this direct growth contribution, the sector also contributed in an indirect way to economic growth by generating knowledge and productivity spill-overs for other industries. The knowledge role of business services is reflected in its employment characteristics. The business-services industry created spill-overs in three ways: original innovations, knowledge diffusion, and the reduction of human capital indivisibilities at firm level. The share of knowledge-intensive business services in the intermediate inputs of the total economy has risen sharply in the last decade. Firm-level scale diseconomies with regard to knowledge and skill inputs are reduced by external deliveries of such inputs, thereby exploiting positive external scale economies. The process goes along with an increasingly complex social division of labour between economic sectors. The European business-services industry itself is characterised by a relatively weak productivity growth. Does this contribute to growth stagnation tendencies à la the socalled “Baumol disease”? The paper argues that there is no reason to expect this as long as the productivity and growth spill-overs from business services to other sectors are large enough. Finally, the paper concludes by suggesting several policy elements that could boost the role of business services in European economic growth. This might to achieve some of the ambitious Lisbon goals with respect to employment, productivity and innovation.

Consensus, contradiction, and conciliation of interests: the geo-economics of the Energy Union. EPC Policy Brief, 8 July 2015

European Union energy policy calls for nothing less than a profound transformation of the EU's energy system: by 2050 decarbonised electricity generation with 80-95% fewer greenhouse gas emissions, increased use of renewables, more energy efficiency, a functioning energy market and increased security of supply are to be achieved. Different EU policies (e.g., EU climate and energy package for 2020) are intended to create the political and regulatory framework for this transformation. The sectorial dynamics resulting from these EU policies already affect the systems of electricity generation, transportation and storage in Europe, and the more effective the implementation of new measures the more the structure of Europe's power system will change in the years to come. Recent initiatives such as the 2030 climate/energy package and the Energy Union are supposed to keep this dynamic up. Setting new EU targets, however, is not necessarily the same as meeting them. The impact of EU energy policy is likely to have considerable geo-economic implications for individual member states: with increasing market integration come new competitors; coal and gas power plants face new renewable challengers domestically and abroad; and diversification towards new suppliers will result in new trade routes, entry points and infrastructure. Where these implications are at odds with powerful national interests, any member state may point to Article 194, 2 of the Lisbon Treaty and argue that the EU's energy policy agenda interferes with its given right to determine the conditions for exploiting its energy resources, the choice between different energy sources and the general structure of its energy supply. The implementation of new policy initiatives therefore involves intense negotiations to conciliate contradicting interests, something that traditionally has been far from easy to achieve. In areas where this process runs into difficulties, the transfer of sovereignty to the European level is usually to be found amongst the suggested solutions. Pooling sovereignty on a new level, however, does not automatically result in a consensus, i.e., conciliate contradicting interests. Rather than focussing on the right level of decision making, European policy makers need to face the (inconvenient truth of) geo-economical frictions within the Union that make it difficult to come to an arrangement. The reminder of this text explains these latter, more structural and sector-related challenges for European energy policy in more detail, and develops some concrete steps towards a political and regulatory framework necessary to overcome them.

Dynamical Scenarios for Chromosome Bi-orientation

Chromosome bi-orientation at the metaphase spindle is essential for precise segregation of the genetic material. The process is error-prone, and error-correction mechanisms exist to switch misaligned chromosomes to the correct, bi-oriented configuration. Here, we analyze several possible dynamical scenarios to explore how cells might achieve correct bi-orientation in an efficient and robust manner. We first illustrate that tension-mediated feedback between the sister kinetochores can give rise to a bistable switch, which allows robust distinction between a loose attachment with low tension and a strong attachment with high tension. However, this mechanism has difficulties in explaining how bi-orientation is initiated starting from unattached kinetochores. We propose four possible mechanisms to overcome this problem (exploiting molecular noise; allowing an efficient attachment of kinetochores already in the absence of tension; a trial-and-error oscillation; and a stochastic bistable switch), and assess their impact on the bi-orientation process. Based on our results and supported by experimental data, we put forward a trial-and-error oscillation and a stochastic bistable switch as two elegant mechanisms with the potential to promote bi-orientation both efficiently and robustly.

Conciliar o novo turista com destinos sol e praia

Um destino de sol e praia, nos dias de hoje, trava uma luta constante para manter ou criar atributos que sejam capazes de atrair turistas às suas costas; torna-se por isso importante conhecer o que permite deixar todos esses turistas “agarrados” ao destino promovendo a volta ao mesmo, tantas vezes quantas as possíveis. Explorar os níveis de lealdade apresentados por (Oliver, 1999) num destino como o Algarve numa tentativa de perceber a persistência deste tipo de destinos, focando neste caso os turistas não residentes, pela importância que este tipo de mercados representa para a sustentabilidade do destino. Pretende-se perceber o que influencia a duração da estadia e a relação do turista com o destino – compromisso - e como se relacionam com aquelas construções teóricas, recorrendo à Análise de Equações Estruturais para a sua concretização, tentando contribuir desta forma para a compreensão das dinâmicas que continuam a promover a escolha destes destinos nos dias de hoje.

Genomic amplification of the caprine EDNRA locus might lead to a dose dependent loss of pigmentation

The South African Boer goat displays a characteristic white spotting phenotype, in which the pigment is limited to the head. Exploiting the existing phenotype variation within the breed, we mapped the locus causing this white spotting phenotype to chromosome 17 by genome wide association. Subsequent whole genome sequencing identified a 1 Mb copy number variant (CNV) harboring 5 genes including EDNRA. The analysis of 358 Boer goats revealed 3 alleles with one, two, and three copies of this CNV. The copy number is correlated with the degree of white spotting in goats. We propose a hypothesis that ectopic overexpression of a mutant EDNRA scavenges EDN3 required for EDNRB signaling and normal melanocyte development and thus likely lead to an absence of melanocytes in the non-pigmented body areas of Boer goats. Our findings demonstrate the value of domestic animals as reservoir of unique mutants and for identifying a precisely defined functional CNV.

A Comprehensive Discussion of HMBC Pulse Sequences: 4. Establishing Two-Bond Correlations from HMBC and Related Experiments

The utility of the HMBC experiment for structure elucidation is unquestionable, but the nature of the coupling pathways leading to correlations in an HMBC experiment creates the potential for misinterpretation. This misinterpretation potential is intimately linked to the size of the long-range heteronuclear couplings involved, and may become troublesome in those cases of a particularly strong 2JCH correlation that might be mistaken for a 3JCH correlation or a 4JCH correlation of appreciable strength that could be mistaken for a weaker 3JCH correlation. To address these potential avenues of confusion, work from several laboratories has been focused on the development of what might be considered “coupling pathway edited” long-range heteronuclear correlation experiments that are derived from or related to the HMBC experiment. The first example of an effort to address the problems associated with correlation path length was seen in the heteronucleus-detected XCORFE experiment described by Reynolds and co-workers that predated the development of the HMBC experiment. Proton-detected analogs of the HMBC experiment intended to differentiate 2JCH correlations from nJCH correlations where n = 3, 4, include the 2J,3J-HMBC, HMBC-RELAY, H2BC, edited-HMBC, and HAT H2BC experiments. The principles underlying the critical components of each of these experiments are discussed and experimental verification of the results that can be obtained using model compounds are shown. This contribution concludes with a brief discussion of the 1,1-ADEQUATE experiments that provide an alternative means of identifying adjacent protonated and non-protonated carbon correlations by exploiting 1JCC correlations at natural abundance.

Edge caching with mobility prediction in virtualized LTE mobile networks

Abstract Mobile Edge Computing enables the deployment of services, applications, content storage and processing in close proximity to mobile end users. This highly distributed computing environment can be used to provide ultra-low latency, precise positional awareness and agile applications, which could significantly improve user experience. In order to achieve this, it is necessary to consider next-generation paradigms such as Information-Centric Networking and Cloud Computing, integrated with the upcoming 5th Generation networking access. A cohesive end-to-end architecture is proposed, fully exploiting Information-Centric Networking together with the Mobile Follow-Me Cloud approach, for enhancing the migration of content-caches located at the edge of cloudified mobile networks. The chosen content-relocation algorithm attains content-availability improvements of up to 500 when a mobile user performs a request and compared against other existing solutions. The performed evaluation considers a realistic core-network, with functional and non-functional measurements, including the deployment of the entire system, computation and allocation/migration of resources. The achieved results reveal that the proposed architecture is beneficial not only from the users’ perspective but also from the providers point-of-view, which may be able to optimize their resources and reach significant bandwidth savings.

Benthic foraminifera and phytodetritus species in sediments from DSDP Leg 85, and ODP Legs 113 and 143

From late middle Eocene through earliest Oligocene, high-latitude regions cooled, and by the end of the period, continental ice sheets existed in Antarctica. Diversity of planktonic microorganisms declined, and modern groups of terrestrial vertebrates originated. Coeval faunal changes in deep-sea benthic foraminifers have been related to cooling of deep waters and increased oxygenation. Cooling, however, occurred globally, whereas species richness declined at high latitudes and not in the tropics. The late Eocene and younger lower-diversity, high-latitude faunas typically contain common Epistominella exigua and Alabaminella weddellensis, opportunistic phytodetritus-exploiting species that indicate a seasonally fluctuating input of organic matter to the sea floor. We speculate that the species-richness gradient and increase in abundance of phytodetritus-exploiting species resulted largely from the onset of a more unpredictable and seasonally fluctuating food supply, especially at high latitudes.

Analysis of minerals from Arctic Ocean sediments

The Arctic Ocean System is a key player regarding the climatic changes of Earth. Its highly sensitive ice Cover, the exchange of surface and deep water masses with the global ocean and the coupling with the atmosphere interact directly with global climatic changes. The output of cold, polar water and sea ice influences the production of deep water in the North Atlantic and controls the global ocean circulation ("the conveyor belt"). The Arctic Ocean is surrounded by the large Northern Hemisphere ice sheets which not only affect the sedimentation in the Arctic Ocean but also are supposed to induce the Course of glacials and interglacials. Terrigenous sediment delivered from the ice sheets by icebergs and meltwater as well as through sea ice are major components of Arctic Ocean sediments. Hence, the terrigenous content of Arctic Ocean sediments is an outstanding archive to investigate changes in the paleoenvironment. Glazigenic sediments of the Canadian Arctic Archipelago and surface samples of the Arctic Ocean and the Siberian shelf regions were investigated by means of x-ray diffraction of the bulk fraction. The source regions of distinct mineral compositions were to be deciphered. Regarding the complex circumpolar geology stable christalline shield rocks, active and ancient fold belts including magmatic and metamorphic rocks, sedimentary rocks and wide periglacial lowlands with permafrost provide a complete range of possible mineral combinations. Non- glaciated shelf regions mix the local input from a possible point source of a particular mineral combination with the whole shelf material and function as a sampler of the entire region draining to the shelf. To take this into account, a literature research was performed. Descriptions of outcropping lithologies and Arctic Ocean sediments were scanned for their mineral association. The analyses of glazigenic and shelf sediments yielded a close relationship between their mineral composition and the adjacent source region. The most striking difference between the circumpolar source regions is the extensive outcrop of carbonate rocks in the vicinity of the Canadian Arctic Archipelago and in N Greenland while siliciclastic sediments dominate the Siberian shelves. In the Siberian shelf region the eastern Kara Sea and the western Laptev Sea form a destinct region defined by high smectite, (clino-) pyroxene and plagioclase input. The source of this signal are the extensive outcrops of the Siberian trap basalt in the Putorana Plateau which is drained by the tributaries of the Yenissei and Khatanga. The eastern Laptev Sea and the East Siberian Sea can also be treated as one source region containing a feldspar, quartz, illite, mica, and chlorite asscciation combined with the trace minerals hornblende and epidote. Franz Josef Land provides a mineral composition rich in quartz and kaolinite. The diverse rock suite of the Svalbard archipelago distributes specific mineral compositions of highly metamorphic christalline rocks, dolomite-rich carbonate rocks and sedimentary rocks with a higher diagenetic potential manifested in stable newly built diagenetic minerals and high organic maturity. To reconstruct the last 30,000 years as an example of the transition between glacial and interglacial conditions a profile of sediment cores, recovered during the RV Polarstern" expedition ARK-VIIIl3 (ARCTIC '91), and additional sediment cores around Svalbard were investigated. Besides the mineralogy of different grain size fractions several additional sedimentological and organo-geochemical Parameterswere used. A detailed stratigraphic framework was achieved. By exploiting this data set changes in the mineral composition of the Eurasian Basin sediments can be related to climatic changes. Certain mineral compositions can even be associated with particular transport processes, e.g. the smectitel pyroxene association with sea ice transport from the eastern Kara Sea and the western Laptev Sea. Hence, it is possible to decipher the complex interplay between the influx of warm Atlantic waters into the Southwest of the Eurasian Basin, the waxing and waning of the Svalbard1Barents- Sea- and Kara-Sea-Ice-Sheets, the flooding of the Siberian shelf regions and the surface and deep water circulation. Until now the Arctic Ocean was assumed to be a rather stable System during the last 30,000 years which only switched from a completely ice covered situation during the glacial to seasonally Open waters during the interglacial. But this work using mineral assemblages of sediment cores in the vicinity of Svalbard revealed fast changes in the inflow of warm Atlantic water with the Westspitsbergen Current (< 1000 years), short periods of advances and retreats of the marine based Eurasian ice sheets (1000-3000 years), and short melting phases (400 years?). Deglaciation of the marine-based Eurasian and the land-based north American and Greenland ice sheets are not simultaneous. This thesis postulates that the Kara Sea Ice Sheet released an early meltwater signal prior to 15,000 14C years leading the Barents Sea Ice Sheet while the western land-based ice sheets are following later than 13,500 14C years. The northern Eurasian Basin records the shift between iceberg and sea-ice material derived from the Canadian Arctic Archipelago and N-Greenland and material transported by sea-ice and surface currents from the Siberian shelf region. The phasing of the deglaciation becomes very obvious using the dolomite and quartd phyllosilicate record. It is also supposed that the flooding of the Laptev Sea during the Holocene is manifested in a stepwise increase of sediment input at the Lomonosov Ridge between the Eurasian and Amerasian Basin. Depending on the strength of meltwater pulses from the adjacent ice sheets the Transpolar Drift can probably be relocated. These movements are traceable by the distribution of indicator minerals. Based on the outcome of this work the feasibility of bulk mineral determination can be qualified as excellent tool for paleoenvironmental reconstructions in the Arctic Ocean. The easy preparation and objective determination of bulk mineralogy provided by the QUAX software bears the potential to use this analyses as basic measuring method preceding more time consuming and highly specialised mineralogical investigations (e.g. clay mineralogy, heavy mineral determination).

Graph-based Semi-Supervised Learning in Acoustic Modeling for Automatic Speech Recognition

Thesis (Ph.D.)--University of Washington, 2016-06

Why do US banks borrow from the Fed? A fresh look at the ‘reluctance’ phenomenon

The role of several theoretical factors in determining the demand of US banks for borrowed reserves from the Fed is empirically investigated. The main objective is to isolate the candidate(s) most likely responsible for the recent observed phenomenon of banks reluctance to borrow from the Fed, particularly since the mid-1980s. The results indicate that the declining number of banks due to mergers and consolidations holds much of the weight for explaining the weakened demand for borrowed reserves since the mid-1980s. Consistent evidence is found suggesting that US banks may have been unlawfully exploiting the discount window service for profit-taking purposes. This finding proves credible and suggests the need for further loan scrutiny at the Federal discount window.

Media, 'Madness' and Ethical Journalism

This article analyses the way newspapers and journalists sometimes fail to acknowledge and resolve some of the contentious ethical dilemmas associated with reporting news. Its focus is on not exploiting and vilifying the vulnerable, especially people with mental illness, through sensationalism and inaccurate and imprecise use of medical terminology such as "psycho ". "schizo" or "lunatic ". Because ethics is central to our understanding of professionalism, this article uses professions and professionalism as benchmarks aginst which to analyse and critique how journalists and newspapers define and report news.Sometimes journalists fail the test of good ethical practice in terms of negative. outdated and inaccurate expressions they use in the news stories they report. Likewise, regulators of news industry standards appear not to recognize and sanction such reporting. The apparent inability to resolve these ethical dilemmas creates a context conducive to tolerance for, not acceptance of. unethical news reporting.

Hyperspace geography: Visualizing fitness landscapes beyond 4D

Human perception is finely tuned to extract structure about the 4D world of time and space as well as properties such as color and texture. Developing intuitions about spatial structure beyond 4D requires exploiting other perceptual and cognitive abilities. One of the most natural ways to explore complex spaces is for a user to actively navigate through them, using local explorations and global summaries to develop intuitions about structure, and then testing the developing ideas by further exploration. This article provides a brief overview of a technique for visualizing surfaces defined over moderate-dimensional binary spaces, by recursively unfolding them onto a 2D hypergraph. We briefly summarize the uses of a freely available Web-based visualization tool, Hyperspace Graph Paper (HSGP), for exploring fitness landscapes and search algorithms in evolutionary computation. HSGP provides a way for a user to actively explore a landscape, from simple tasks such as mapping the neighborhood structure of different points, to seeing global properties such as the size and distribution of basins of attraction or how different search algorithms interact with landscape structure. It has been most useful for exploring recursive and repetitive landscapes, and its strength is that it allows intuitions to be developed through active navigation by the user, and exploits the visual system's ability to detect pattern and texture. The technique is most effective when applied to continuous functions over Boolean variables using 4 to 16 dimensions.