Three-dimensional visualization of human hemoglobin phenotypes with HPLC

Hemoglobinopathies were included in the Brazilian Neonatal Screening Program on June 6, 2001. Automated high-performance liquid chromatography (HPLC) was indicated as one of the diagnostic methods. The amount of information generated by these systems is immense, and the behavior of groups cannot always be observed in individual analyses. Three-dimensional (3-D) visualization techniques can be applied to extract this information, for extracting patterns, trends or relations from the results stored in databases. We applied the 3-D visualization tool to analyze patterns in the results of hemoglobinopathy based on neonatal diagnosis by HPLC. The laboratory results of 2520 newborn analyses carried out in 2001 and 2002 were used. The Fast, F1, F and A peaks, which were detected by the analytical system, were chosen as attributes for mapping. To establish a behavior pattern, the results were classified into groups according to hemoglobin phenotype: normal (N = 2169), variant (N = 73) and thalassemia (N = 279). 3-D visualization was made with the FastMap DB tool; there were two distribution patterns in the normal group, due to variation in the amplitude of the values obtained by HPLC for the F1 window. It allowed separation of the samples with normal Hb from those with alpha thalassemia, based on a significant difference (P > 0.05) between the mean values of the Fast and A peaks, demonstrating the need for better evaluation of chromatograms; this method could be used to help diagnose alpha thalassemia in newborns.

Agricultural incentives, growth and poverty in Latin America and the Caribbean: cross-country evidence for the period 1960-2005. Did trade liberalization increase the incomes of the poorest?

Includes bibliography

Fruit color and contrast in seasonal habitats - a case study from a cerrado savanna

Communication contributes to mediate the interactions between plants and the animals that disperse their genes. As yet, seasonal patterns in plant-animal communication are unknown, even though many habitats display pronounced seasonality e.g. when leaves senescence. We thus hypothesized that the contrast between fruit displays and their background vary throughout the year in a seasonal habitat. If this variation is adaptive, we predicted higher contrasts between fruits and foliage during the fruiting season in a cerrado-savanna vegetation, southeastern Brazil. Based on a six-year data base of fruit ripening and a one-year data set of fruit biomass, we used reflectance measurements and contrast analysis to show that fruits with distinct colors differed in the beginning of ripening and the peak of fruit biomass. Black, and particularly red fruits, that have a high contrast against the leaf background, were highly seasonal, peaking in the wet season. Multicolored and yellow fruits were less seasonal, not limited to one season, with a bimodal pattern for yellow ones, represented by two peaks, one in each season. We further supported the hypothesis that seasonal changes in fruit contrasts can be adaptive because fruits contrasted more strongly against their own foliage in the wet season, when most fruits are ripe. Hence, the seasonal variation in fruit colors observed in the cerrado-savanna may be, at least partly, explicable as an adaptation to ensure high conspicuousness to seed dispersers. © 2013 The Authors.

Desenvolvimento do protótipo de um atlas escolar interativo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Modelagem neutrosférica sobre a América do Sul baseada em PNT e assimilação de dados locais e robusta avaliação utilizando observações GNSS

Pós-graduação em Ciências Cartográficas - FCT

Sistema microcontrolado para medição de forças na região plantar e nos membros superiores de pacientes

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Metodologia e diretrizes para desenvolvimento de um ambiente computacional para ensino a distância

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Diversidade de morcegos em dois fragmentos florestais da região noroeste do Estado do Paraná, Brasil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Indicadores entomológicos dos levantamentos rápidos de infestação de Aedes aegypti e ocorrência de dengue na cidade de Penápolis, São Paulo Brasil. 2006-2010

Pós-graduação em Ciência Animal - FMVA

Contribuições para desenvolvimento da pesquisa e da avaliação em política e gestão educacional com uso de novas tecnologias: desenvolvimento de bases de dados

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Mineração de dados em triagem neonatal de hemoglobinopatias

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Avaliação da qualidade da água do reservatório de Itupararanga, bacia do Alto Sorocaba (SP)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Planejamento do uso do solo em uma bacia hidrográfica para conservação dos recursos hídricos

Pós-graduação em Agronomia (Irrigação e Drenagem) - FCA

Análise comparativa do processo de gramaticalização das perífrases conjuncionais agora que e já que

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A presença das literaturas portuguesa e africana de língua portuguesa no Suplemento Literário Minas Gerais (1966/1988): indexação, coletânea de textos e banco de dados

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)