Máxima fase estável de lactato é ergômetro-dependente em modelo experimental utilizando ratos

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

El desarrollo económico de América Latina en épocas de globalización. Una agenda de investigación

Incluye Bibliografía

Importaciones y modernización económica en América Latina durante la primera mitad del siglo XX: las claves de un programa de investigación

Incluye Bibliografía

Evolução tecnológica em uma firma de processo produtivo continuo no setor metal-mecânico brasileiro

Incluye Bibliografía

El transporte urbano en América Latina: consideraciones acerca de su igualdad y eficiencia

Incluye Bibliografía

Urban transport in Latin America: some considerations on its equity and efficiency

Includes bibliography

Mito e performance na Olímpica I de Píndaro

Pós-graduação em Estudos Literários - FCLAR

Informe sobre la recuperación del patrimonio documental estadístico histórico de la CEPAL. Las series de larga duración sobre las principales variables macroeconómicas de América Latina y el Caribe

Incluye Bibliografía

O impacto da política de permanência estudantil na UNESP - a percepção do aluno bolsista

This research focuses on the inquiry about the impact of the Studentship Program offered by the Academic Extension Board of the São Paulo State University – UNESP. The project emphasized the importance of this program to all college students. The data was obtained through a questionnaire and indicated that the budget invested by the university is essential to the permanence and performance of the low-income students in all graduation courses offered.

Marcos legais para os cursos de graduação em pedagogia no Brasil: análise das atribuições do pedagogo

The current National Curricular Guidelines sets as parameters for Education’s programs the teaching and professional training in order to allow the realization of activities of school tutoring (management) and educational research. Our objective was to analyze educators’ attributions since 1930. For that, we made an analysis of the main laws that guided the activities of these professionals. We tried to demonstrate how the educator became from an “old” school teacher (1854-1880) to a primary education professor (end of XIX and XX centuries) and, nowadays, in a “make it all” in schools and in the administrative tasks into the schools. We hope, with this analysis, to contribute to the definition of attributions of the educator in current days and to offer subsidies for a better thinking of the process to students of Education in Brasil, helping in the tutoring of those future professionals.

Early fetoscopic tracheal occlusion for extremely severe pulmonary hypoplasia in isolated congenital diaphragmatic hernia: Preliminary results

Objective: To evaluate the effect of early fetoscopictracheal occlusion (FETO) (22–24 weeks’ gestation) onpulmonary response and neonatal survival in cases ofextremely severe isolated congenital diaphragmatic hernia(CDH). Methods: This was a multicenter study involving fetuseswith extremely severe CDH (lung-to-head ratio < 0.70,liver herniation into the thoracic cavity and no otherdetectable anomalies). Between August 2010 and December 2011, eight fetuses underwent early FETO. Datawere compared with nine fetuses that underwent standard FETO and 10 without fetoscopic procedure fromJanuary 2006 to July 2010. FETO was performed undermaternal epidural anesthesia, supplemented with fetalintramuscular anesthesia. Fetal lung size and vascularitywere evaluated by ultrasound before and every 2 weeksafter FETO. Postnatal therapy was equivalent for bothtreated fetuses and controls. Primary outcome was infantsurvival to 180 days and secondary outcome was fetalpulmonary response. Results: Maternal and fetal demographic characteristicsand obstetric complications were similar in the threegroups (P > 0.05). Infant survival rate was significantlyhigher in the early FETO group (62.5%) comparedwith the standard group (11.1%) and with controls(0%) (P < 0.01). Early FETO resulted in a significantimprovement in fetal lung size and pulmonary vascularitywhen compared with standard FETO (P < 0.01). Conclusions: Early FETO may improve infant survival byfurther increases of lung size and pulmonary vascularityin cases with extremely severe pulmonary hypoplasia inisolated CDH. This study supports formal testing of thehypothesis with a randomized controlled trial.

Loss of Interleukin-10 Signaling and Infantile Inflammatory Bowel Disease: Implications for Diagnosis and Therapy

BACKGROUND & AIMS: Homozygous loss of function mutations in interleukin-10 (IL10) and interleukin-10 receptors (IL10R) cause severe infantile (very early onset) inflammatory bowel disease (IBD). Allogeneic hematopoietic stem cell transplantation (HSCT) was reported to induce sustained remission in 1 patient with IL-10R deficiency. We investigated heterogeneity among patients with very early onset IBD, its mechanisms, and the use of allogeneic HSCT to treat this disorder. METHODS: We analyzed 66 patients with early onset IBD (younger than 5 years of age) for mutations in the genes encoding IL-10, IL-10R1, and IL-10R2. IL-10R deficiency was confirmed by functional assays on patients' peripheral blood mononuclear cells (immunoblot and enzyme-linked immunosorbent assay analyses). We assessed the therapeutic effects of standardized allogeneic HSCT. RESULTS: Using a candidate gene sequencing approach, we identified 16 patients with IL-10 or IL-10R deficiency: 3 patients had mutations in IL-10, 5 had mutations in IL-10R1, and 8 had mutations in IL-10R2. Refractory colitis became manifest in all patients within the first 3 months of life and was associated with perianal disease (16 of 16 patients). Extraintestinal symptoms included folliculitis (11 of 16) and arthritis (4 of 16). Allogeneic HSCT was performed in 5 patients and induced sustained clinical remission with a median follow-up time of 2 years. In vitro experiments confirmed reconstitution of IL-10R-mediated signaling in all patients who received the transplant. CONCLUSIONS: We identified loss of function mutations in IL-10 and IL-10R in patients with very early onset IBD. These findings indicate that infantile IBD patients with perianal disease should be screened for IL-10 and IL-10R deficiency and that allogeneic HSCT can induce remission in those with IL-10R deficiency.