Hematologic changes in propofol-anesthetized dogs with or without tramadol administration

Drugs commonly used in anesthesia practice may significantly alter the oxidative state of blood cells. This mechanism could contribute to the immune suppression that occurs transiently in the early postoperative period. Thus, we assessed the effects of continuous rate infusion (CRI) of propofol associated or not with tramadol on hematologic parameters in dogs. Eight adult mongrel dogs were anesthetized on 2 occasions, 15 d apart. Two groups were formed: control group (CG) and tramadol group (GT). Propofol was used for induction (10mg kg-1) followed by a CRI (0.7mg kg-1minute-1). The animals were positioned in lateral recumbency and mechanically ventilated with inspired oxygen fraction of 0.6. In TG, tramadol (2mg kg-1) followed by a CRI (0.5mg kg-1minute-1) was administered in dogs. In the CG the sodium chloride (NaCl) solution at 0.9% was administered followed by its CRI, in the same volume that was used in TG. The measurement was taken before anesthesia induction (Tbasal), 30 minutes after induction (T0) and then at 30-minute intervals (T30 to T60). Red blood cells, hematocrit, hemoblogin concentration and total leukocytes count decreased from T0 in both groups. In TG, lymphocytes count at Tbasal [1.86 (0.82) x103µl-1] was greater than at T0, T30 and T60 [0.96(0.50), 0.92(0.48) and 0.95(0.48) x103µl-1, respectively]. No significant differences were observed for platelets neutrophil, eosinophil, basophil and monocyte count. In dogs, propofol-anesthesia associated or not with tramadol promoted decrease in blood cell count and should be used with caution in immunossupressed patients.

Comparison of shear bond strength of orthodontics brackets on composite resin restorations with different surface treatments

INTRODUÇÃO: frequentemente, os pacientes ortodônticos apresentam restaurações de resina composta; no entanto, existem poucos estudos que avaliam a melhor forma de colagem ortodôntica nessa situação. OBJETIVO: o objetivo do presente trabalho foi avaliar a força adesiva de braquetes ortodônticos em restaurações resinosas com tratamento de superfície. MÉTODOS: foram utilizados 51 incisivos inferiores bovinos divididos aleatoriamente em três grupos. No grupo controle (GC), os braquetes foram colados em esmalte dentário; nos grupos experimentais com tratamento (GCT) e sem tratamento (GST), os braquetes foram colados em restauração de resina previamente realizada, diferenciando-se pelo tratamento de superfície com broca diamantada. Os dentes foram incluídos em tubos de PVC com resina acrílica autopolimerizável. O ensaio de cisalhamento foi executado em máquina universal de ensaios Emic. Os grupos foram submetidos à ANOVA com pós-teste de Tukey para verificação da diferença estatística entre os grupos (α = 0,05). RESULTADOS: GC (6,62MPa) e GCT (6,82MPa) apresentaram resultados semelhantes, enquanto o GST (5,07MPa) obteve resultados estatisticamente menores (p < 0,05). CONCLUSÃO: conclui-se que a melhor técnica de colagem de braquetes ortodônticos em restaurações de resina composta é a de realização de desgaste sobre a superfície.

Efeito do treinamento com pesos na pressão arterial de repouso em idosas normotensas

INTRODUCTION: Resistance training (RT) has been widely used for older adults in order to minimize or reverse the deleterious effects of aging in the neuromuscular system. However, the potential benefits of RT on arterial blood pressure and heart rate at rest in older adults remain controversial. OBJECTIVE: To analyze the effect of eight weeks of RT on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) in older women without hypertension. METHODS: Seventeen women (aged 66.0 ± 5.8 years) without previous experience in RT were randomly assigned to either a training (TG, n = 10) or control (CG, n = 7) groups. Hemodynamic parameters at rest were evaluated by auscultatory method (mercury sphygmomanometer) and HR monitor (Polar), before and after eight weeks of experimental period. RESULTS: Reductions attributable to RT were found only to SBP (-13.4 mmHg, p <0.01). Although significant reductions were observed for DBP and MBP, the analysis of covariance showed no interaction Group x Time significant. CONCLUSION: RT proved an effective training to promote adaptations in the cardiovascular system of older women without hypertension. Eight weeks of RT can significantly reduce SBP at rest in older women.

Semen parameters and seminal plasma protein and biochemical profiles of dogs with benign prostatic hyperplasia after botulinum toxin type A intraprostatic injection

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Experimental infection of one-day-old chicks with Salmonella Serotypes Previously isolated from poultry facilities, wild birds, and swine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Plasma rico em plaquetas empregado na cirurgia reconstrutiva em coelhos (Oryctolagus cuniculus): avaliação da exequibilidade da técnica, achados macroscópicos e histopatológicos

Pós-graduação em Cirurgia Veterinária - FCAV

Caracterização da narrativa oral de história de indivíduos com transtorno do espectro alcoólico fetal

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Processamento auditivo em trabalhadores expostos a ruído e inseticida: testes de ordenação temporal e P300

Pós-graduação em Fonoaudiologia - FFC

Expressão gênica e proteica e cinética celular no processo inflamatório induzido pela Helicobacter pylori antese após terapia de erradicação

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo genético quantitativo da qualidade da carcaça e da carne e suas associações com as características de avaliação visual na raça Nelore

Pós-graduação em Genética e Melhoramento Animal - FCAV

Modelos bayesianos para análise de características reprodutivas de fêmeas Nelore

Pós-graduação em Genética e Melhoramento Animal - FCAV

Participação hepática e efeito glicocorticoide na resposta inflamatória aguda induzida por Aeromonas hydrophila em tilápia do Nilo, intoxicada por CCl4

Pós-graduação em Medicina Veterinária - FCAV

Sintese e aplicação de filmes biocomponentes nanoestruturados de 'TI'/'TI''O IND.2'/'W''O IND.3' por template e 'SI'/'TI''O IND.2'/'PT' por heterojunção em conversão de energia solar e remediação ambiental

Pós-graduação em Química - IQ

Efeito do treinamento físico sobre o perfil metabólico e ósseo de ratos recém-desmamados

Introduction: The practice of moderate-intensity exercise can reduce the risk of infections and improve metabolic aspects of the person. Objective: To investigate the effects of aerobic physical training on endocrine and metabolic aspects, bone and immune system. Methods: Twenty Wistar rats were divided in two groups: sedentary (GS) and trained group (TG). Training program consisted in swimming, 6 weeks, supporting a workload corresponding to 5% of body weight. At the end of the experiment, were performed counting total and differential leukocyte count and hematocrit. After training period, were analyzed glucose, total protein, triglycerides, cholesterol, liver and muscle samples for the determination of the levels of glycogen, and determination of the tibia length and bone area. All dependent variables were analyzed by one-way analysis of variance (ANOVA) and a significance level of P < 0.05 was used for all comparisons. Results: Hematocrit (%) analyzed showed a significant difference, with higher values for TG (54.63 +/- 1.41) than for the GS (49.5 +/- 1.65). The total leukocyte count was not significantly different, as there was no difference in the differential count. Total cholesterol showed significant decrease in GT (GT = 68.27 +/- 13.71 mg/dL; GS = 94.44 +/- 28.09), the total protein levels also showed significant reduction (GT = 7.3 +/- 0,40 g/dL; GS = 7.74 +/- 0.36 g/dL) glucose levels and triglyceride showed no significant differences. The bone length showed a significant difference (GT = 40 +/- 0.14 mm; CG = 42.10 +/- 0.12mm). The tibial area showed the lowest value for the GT (1.53 +/- 0.12cm(2)) than for the GS (1.67 +/- 0.18cm(2)) however the difference was not statistically significant. Conclusion: It can be concluded that aerobic exercise training is able to produce some unique physiological changes in young rats. There is also the need to prescribe exercises that meet the particular maturational stage of development.

Quantitative genetic study of age at subsequent rebreeding in Nellore cattle by using survival analysis

The continuous trait age at subsequent rebreeding (ASR) was evaluated using survival analysis in Nellore breed cows that conceived for the first time at approximately 14 months of age. This methodology was chosen because the restricted breeding season produces censored data. The dataset contained 2885 records of ASR (in days). Records of females that did not produce calves in the following year after being exposed to a sire were considered censored (48.3% of the total). The statistical model used was a Weibull mixed survival model, which included fixed effects of contemporary groups (CG) and period and a random effect of individual animal. The effect of contemporary groups on ASR was significant (P < 0.01). Heritabilities obtained for ASR were 0.03 and 0.04 in logarithmic and original scales, respectively. These results indicate that the genetic selection response for subsequent reproduction of 2-year-old Nellore breed females is not expected to be effective based on survival analysis. Furthermore, these results suggest that environmental improvement is fundamental to this important trait. It should be highlighted that an increase in the average date of birth can produce an adverse effect in the future, since this cannot be compensated by genetic improvement.