The Alzheimer disease afflicted : understanding the disease and the resident instructors guide and teaching materials /

On cover: New horizons in long term care.

Variae lectiones ad textum Act. App. Epp. Catholicarum et Pauli ...

Mode of access: Internet.

Eine Auswahl für Freunde der altern vaterländischen Dichtkunst,

Mode of access: Internet.

Die evangelischen kirchen rettung von falscher Beschuldigung der trennund und gemeinschafft mit altern ketzereyen : ausz gnädigstem befehl des durchläuchtigsten ... in das Churfürstlichens Sämländische Consistorium eingegebenen dubiis /

Mode of access: Internet.

Q & A : Alzheimer's disease.

Mode of access: Internet.

Organizational maintenance repair parts and special tools lists : power plant, utility (MUST) gas turbine engine, (Amertech Corp. model APP-1), NSN 6115-00-937-0929.

Includes index.

Direct support and general support maintenance manual : power plant, utility (MUST) gas turbine engine driven (Amertech Corporation model no. APP-1), NSN 6115-00-937-0929.

Includes index.

Operator and organizational maintenance manual : power plant, utility, (MUST) gas turbine engine driven (Amertech Corporation model no. APP-1), NSN 6115-00-937-0929 (non-winterized) and NSN 6115-00-134-0825 (winterized).

Includes index.

Direct support and general support maintenance repair parts and special tools lists ... : power plant, utility (MUST) gas turbine engine (Amertech Corp model APP-1), NSN 6115-00-937-0929.

"7 September 1979."

Moderating Variables Impacting Adherence to the Reducing Disability in Alzheimer's Disease (RDAD) Intervention

Thesis (Ph.D.)--University of Washington, 2016-06

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease

We recently reported that a linkage disequilibrium (LD) block on chromosome 10q encompassing the gene encoding insulin-degrading enzyme (IDE) harbors sequence variants that associate with Alzheimer disease (AD). Evidence also indicated effects upon a number of quantitative indices of AD severity, including age-at-onset (AAO). Since linkage of this immediate region to AAO has been shown in both AD and Parkinson disease (PD), we have explored the possibility that polymorphism within this LD block might also influence PD. Utilizing single nucleotide polymorphisms that delineate common haplotypes from this region, we observed significant evidence of association with AAO in an Australian PD case-control sample. Analyses were complemented with AAO data from two independent Swedish AD case samples, for which previously reported findings were replicated. Results were consistent between AD and PD, suggesting the presence of equivalent detrimental and protective alleles. These data highlight a genomic region in the proximity of IDE that may contribute to AD and PD in a similar manner.

Selective loss of NMDA receptor NR1 subunit isoforms in Alzheimer's disease

Previous work had shown that the ratio of NMDA receptor NR1 subunit mRNA transcripts containing an N-terminal splice cassette to those that do not is markedly lower in regions of the Alzheimer's disease (AD) brain that are susceptible to pathological damage, compared with spared regions in the same cases or homotropic regions in controls. To elucidate the origins of this difference in proportionate expression, we measured the absolute levels of each of the eight NR1 transcripts by quantitative internally standardized RT-PCR assay. Expression of transcripts with the cassette was strongly attenuated in susceptible regions of Alzheimer's brain, whereas expression of non-cassette transcripts differed little from that in controls. The expression of other NR1 splice variants was not associated with pathology relevant to disease status, although some combinations of splice cassettes were well maintained in AD cases. The population profile of NR1 transcripts in occipital cortex differed from the profiles in other brain regions studied. Western analysis confirmed that the expression of protein isoforms containing the N-terminal peptide was very low in susceptible areas of the Alzheimer's brain. Cells that express NR1 subunits with the N-terminal cassette may be selectively vulnerable to toxicity in AD.