Den 13 Januari

Simananniemen käsikirjoituskokoelma.

Congenital anomalies associated with trisomy 18 or trisomy 13: A registry-based study in 16 european countries, 2000-2011.

The aim of this study was to examine the prevalence of trisomies 18 and 13 in Europe and the prevalence of associated anomalies. Twenty-five population-based registries in 16 European countries provided data from 2000-2011. Cases included live births, fetal deaths (20+ weeks' gestation), and terminations of pregnancy for fetal anomaly (TOPFAs). The prevalence of associated anomalies was reported in live births. The prevalence of trisomy 18 and trisomy 13 were 4.8 (95%CI: 4.7-5.0) and 1.9 (95%CI: 1.8-2.0) per 10,000 total births. Seventy three percent of cases with trisomy 18 or trisomy 13 resulted in a TOPFA. Amongst 468 live born babies with trisomy 18, 80% (76-83%) had a cardiac anomaly, 21% (17-25%) had a nervous system anomaly, 8% (6-11%) had esophageal atresia and 10% (8-13%) had an orofacial cleft. Amongst 240 Live born babies with trisomy 13, 57% (51-64%) had a cardiac anomaly, 39% (33-46%) had a nervous system anomaly, 30% (24-36%) had an eye anomaly, 44% (37-50%) had polydactyly and 45% (39-52%) had an orofacial cleft. For babies with trisomy 18 boys were less likely to have a cardiac anomaly compared with girls (OR = 0.48 (0.30-0.77) and with trisomy 13 were less likely to have a nervous system anomaly [OR = 0.46 (0.27-0.77)]. Babies with trisomy 18 or trisomy 13 do have a high proportion of associated anomalies with the distribution of anomalies being different in boys and girls. © 2015 Wiley Periodicals, Inc.

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose.

Glucose is the primary source of energy for the brain but also an important source of building blocks for proteins, lipids, and nucleic acids. Little is known about the use of glucose for biosynthesis in tissues at the cellular level. We demonstrate that local cerebral metabolic activity can be mapped in mouse brain tissue by quantitatively imaging the biosynthetic products deriving from [U-(13)C]glucose metabolism using a combination of in situ electron microscopy and secondary ion mass-spectroscopy (NanoSIMS). Images of the (13)C-label incorporated into cerebral ultrastructure with ca. 100nm resolution allowed us to determine the timescale on which the metabolic products of glucose are incorporated into different cells, their sub-compartments and organelles. These were mapped in astrocytes and neurons in the different layers of the motor cortex. We see evidence for high metabolic activity in neurons via the nucleus (13)C enrichment. We observe that in all the major cell compartments, such as e.g. nucleus and Golgi apparatus, neurons incorporate substantially higher concentrations of (13)C-label than astrocytes.

Enjeux de l'introduction du parcours de soins coordonné en France par la Loi du 13 août 2004

Pour répondre à ces questions sur les enjeux du parcours de soins, nous allons estimer les recours aux médecins ambulatoires en 2003 à partir de l'enquête Santé Insee. Nous nous attacherons plus particulièrement à l'étude de la demande de consultations hors parcours de soins en fonction des déterminants sociodémographiques, économiques et éducatifs. L'objectif est d'évaluer si le cadre de la loi à la potentialité de bouleverser les pratiques de recours aux médecins ambulatoires, et d'évaluer les personnes qui ne s'inscrivent pas dans le schéma du parcours de soins coordonné et d'estimer les impacts possibles des incitations financières mises en place. Nous essayerons ensuite, au regard de nos résultats, de comprendre les objectifs de politique publique de cette réforme. [P. 15]

Sonata No. 1 in A Major for Violin and Piano, Op. 13

Soitinnus: Viulu, piano.

Etudes Symphoniques, Op. 13

Soitinnus: Piano.

Conxita Boncompte,"Iconografia picassiana (1905­-1907). Influencia de la pintura pompeiana". Goya, núm. 335 (2011), pp. 156­-179

La personalitat de Pablo Picasso es una de les més estudiades a la història de l"art, Per aquest motiu són destacables els estudis que hi ha dedicat la Dra. Conxita Boncompte, una aportació que te, a més el valor afegit, que és el resultat d"una tesi doctoral presentada a la Universitat de Barcelona. El llarg article, 24 pàgines de text amb 108 notes documentals, ha estat publicat a revista Goya, editada per la Fundación Lázaro Galdeano de Madrid, i una de les més prestigioses en llengua castellana en Història de l"Art.

Jousikvartetto, op. 12 [!] [nro 13]

Digitoitu 11. 7. 2008

[Cadenze op. 13]

Soitinnus: viulu.