Prevención de lesiones en el deporte. Claves para un rendimiento deportivo óptimo. Romero Rodríguez, Daniel y Tous Fajardo, Julio. Medica Panamericana D. L., Madrid, 2010

La obra presenta variados temas, alguno de los cuales son abordados en forma general y en otros los autores profundizan introduciendo al lector en el verdadero campo de la prevención. Dentro de estos temas dedican un capítulo a uno de los pilares más importantes para la determinación de puntos débiles, que es la valoración de los aspectos necesarios de la forma física en relación a la posibilidad de lesiones, es decir, poder determinar el perfil lesivo de cada deportista. Se presentan metodologías de tratamiento en la prevención de lesiones basadas en tres pilares fundamentales: enfoque neuromuscular, entrenamiento de la fuerza para orientar los tratamientos y priorizar el componente excéntrico del movimiento como base funcional para la prevención. Así mismo incorpora una metodología de trabajo por medio de la vibración

Prevención de lesiones en el deporte. Claves para un rendimiento deportivo óptimo. Romero Rodríguez, Daniel y Tous Fajardo, Julio. Medica Panamericana D. L., Madrid, 2010

La obra presenta variados temas, alguno de los cuales son abordados en forma general y en otros los autores profundizan introduciendo al lector en el verdadero campo de la prevención. Dentro de estos temas dedican un capítulo a uno de los pilares más importantes para la determinación de puntos débiles, que es la valoración de los aspectos necesarios de la forma física en relación a la posibilidad de lesiones, es decir, poder determinar el perfil lesivo de cada deportista. Se presentan metodologías de tratamiento en la prevención de lesiones basadas en tres pilares fundamentales: enfoque neuromuscular, entrenamiento de la fuerza para orientar los tratamientos y priorizar el componente excéntrico del movimiento como base funcional para la prevención. Así mismo incorpora una metodología de trabajo por medio de la vibración

La eutonía. Sus principios

El presente trabajo pretende dar cuenta de la Eutonía como práctica corporal dando cuenta de sus objetivos y principios. La Eutonía fue creada por Gerda Alexander.El término, del griego, Eu: bueno, óptimo -Tonus: tensión; expresa la idea de una tonicidad armoniosamente equilibrada en adaptación constante al estado o actividad del momento. Es una disciplina basada en la experiencia del propio cuerpo, que conduce a la persona hacia una toma de conciencia de si misma y propone un aprendizaje para la fluctuación de los tonos neuromuscular, neurovegetativo y psíquico, con su adecuación a las distintas situaciones de la vida, a través de sus Principios. Promueve el desarrollo de la conciencia observadora, del "yo observador", posibilitándole la expansión de la conciencia hacia los distintos dominios del ser y la interacción con el entorno. Los principios son: - conciencia de la piel, el tacto conciente, - experiencia del volumen del cuerpo (espacio interno, tridimensionalidad), - desarrollo conciente de la presencia de los huesos y su orientación en el espacio, - contacto conciente, - experiencia del transporte (reflejo conciente de enderezamiento), - repousser (uso de la fuerza), - vibraciones óseas, - vibraciones vocales, - micromovimientos, microdeslizamientos, - movimientos activos y pasivos, - posiciones de control, - movimiento eutónico.

La eutonía. Sus principios

El presente trabajo pretende dar cuenta de la Eutonía como práctica corporal dando cuenta de sus objetivos y principios. La Eutonía fue creada por Gerda Alexander.El término, del griego, Eu: bueno, óptimo -Tonus: tensión; expresa la idea de una tonicidad armoniosamente equilibrada en adaptación constante al estado o actividad del momento. Es una disciplina basada en la experiencia del propio cuerpo, que conduce a la persona hacia una toma de conciencia de si misma y propone un aprendizaje para la fluctuación de los tonos neuromuscular, neurovegetativo y psíquico, con su adecuación a las distintas situaciones de la vida, a través de sus Principios. Promueve el desarrollo de la conciencia observadora, del "yo observador", posibilitándole la expansión de la conciencia hacia los distintos dominios del ser y la interacción con el entorno. Los principios son: - conciencia de la piel, el tacto conciente, - experiencia del volumen del cuerpo (espacio interno, tridimensionalidad), - desarrollo conciente de la presencia de los huesos y su orientación en el espacio, - contacto conciente, - experiencia del transporte (reflejo conciente de enderezamiento), - repousser (uso de la fuerza), - vibraciones óseas, - vibraciones vocales, - micromovimientos, microdeslizamientos, - movimientos activos y pasivos, - posiciones de control, - movimiento eutónico.

Prevención de lesiones en el deporte. Claves para un rendimiento deportivo óptimo. Romero Rodríguez, Daniel y Tous Fajardo, Julio. Medica Panamericana D. L., Madrid, 2010

La obra presenta variados temas, alguno de los cuales son abordados en forma general y en otros los autores profundizan introduciendo al lector en el verdadero campo de la prevención. Dentro de estos temas dedican un capítulo a uno de los pilares más importantes para la determinación de puntos débiles, que es la valoración de los aspectos necesarios de la forma física en relación a la posibilidad de lesiones, es decir, poder determinar el perfil lesivo de cada deportista. Se presentan metodologías de tratamiento en la prevención de lesiones basadas en tres pilares fundamentales: enfoque neuromuscular, entrenamiento de la fuerza para orientar los tratamientos y priorizar el componente excéntrico del movimiento como base funcional para la prevención. Así mismo incorpora una metodología de trabajo por medio de la vibración

Haemolymph inorganic ion composition of crustaceans from the Southern Ocean

Brachyuran and anomuran decapod crabs do not occur in the extremely cold waters of the Antarctic continental shelf whereas caridean and other shrimp-like decapods, amphipods and isopods are highly abundant. Differing capacities for extracellular ion regulation, especially concerning magnesium, have been hypothesised to determine cold tolerance and by that the biogeography of Antarctic crustaceans. Magnesium is known to have a paralysing effect, which is even more distinct in the cold. As only few or no data exist on haemolymph ionic composition of Sub-Antarctic and Antarctic crustaceans, haemolymph samples of 12 species from these regions were analysed for the concentrations of major inorganic ions (Na+, K+, Ca2+, Mg2+, Cl-, SO4 2-) by ion chromatography. Cation relationships guaranteed neuromuscular excitability in all species. Sulphate and potassium correlated positively with magnesium concentration. The Antarctic caridean decapod as well as the amphipods maintained low (6-20% of ambient sea water magnesium concentration), Sub-Antarctic brachyuran and anomuran crabs as well as the Antarctic isopods high (54-96% of ambient sea water magnesium concentration) haemolymph magnesium levels. In conclusion, magnesium regulation may explain the biogeography of decapods, but not that of the peracarids.

Detecting changes in the basin of attraction of a dynamical system: Application to the postural restoring system

A method that provides athree-dimensional representation ofthe basin ofattraction of a dynamical system from experimen tal data was applied tothe problem ofdynamic balance restoration. The method isbased onthe density ofthe data onthe phase space ofthe system under study and makes use ofmodeling and numerical curve fittingtools.For the dynamical system ofbalance restora tion,the shape and the size of the basin of attraction depend on the dynamics of the postural restoring mechanisms and contain important information regarding the biomechanical,as well as the neuromuscular condition of the individual. The aim ofthis work was toexamine the ability ofthe method todetect, through the observed changes inthe shape and/or the size ofthe calculated basins of attraction, (a)the inherent differences between different systems (in the current application, postural restoring systems of different individuals)and (b)induced chan ges in the same system (thepostural restoring system of an individual).The results ofthe study confirm the validity of the method and furthermore justify its robustness.

Experimental implementation of a biometric laser synaptic sensor

We fabricate a biometric laser fiber synaptic sensor to transmit information from one neuron cell to the other by an optical way. The optical synapse is constructed on the base of an erbium-doped fiber laser, whose pumped diode current is driven by a pre-synaptic FitzHugh–Nagumo electronic neuron, and the laser output controls a post-synaptic FitzHugh–Nagumo electronic neuron. The implemented laser synapse displays very rich dynamics, including fixed points, periodic orbits with different frequency-locking ratios and chaos. These regimes can be beneficial for efficient biorobotics, where behavioral flexibility subserved by synaptic connectivity is a challenge.

Three-dimensional distribution of cortical synapses: a replicated point pattern-based analysis

The biggest problem when analyzing the brain is that its synaptic connections are extremely complex. Generally, the billions of neurons making up the brain exchange information through two types of highly specialized structures: chemical synapses (the vast majority) and so-called gap junctions (a substrate of one class of electrical synapse). Here we are interested in exploring the three-dimensional spatial distribution of chemical synapses in the cerebral cortex. Recent research has showed that the three-dimensional spatial distribution of synapses in layer III of the neocortex can be modeled by a random sequential adsorption (RSA) point process, i.e., synapses are distributed in space almost randomly, with the only constraint that they cannot overlap. In this study we hypothesize that RSA processes can also explain the distribution of synapses in all cortical layers. We also investigate whether there are differences in both the synaptic density and spatial distribution of synapses between layers. Using combined focused ion beam milling and scanning electron microscopy (FIB/SEM), we obtained three-dimensional samples from the six layers of the rat somatosensory cortex and identified and reconstructed the synaptic junctions. A total volume of tissue of approximately 4500μm3 and around 4000 synapses from three different animals were analyzed. Different samples, layers and/or animals were aggregated and compared using RSA replicated spatial point processes. The results showed no significant differences in the synaptic distribution across the different rats used in the study. We found that RSA processes described the spatial distribution of synapses in all samples of each layer. We also found that the synaptic distribution in layers II to VI conforms to a common underlying RSA process with different densities per layer. Interestingly, the results showed that synapses in layer I had a slightly different spatial distribution from the other layers.

Three-dimensional spatial distribution of synapses in the neocortex: A dual-beam electron microscopy study

In the cerebral cortex, most synapses are found in the neuropil, but relatively little is known about their 3-dimensional organization. Using an automated dual-beam electron microscope that combines focused ion beam milling and scanning electron microscopy, we have been able to obtain 10 three-dimensional samples with an average volume of 180 µm(3) from the neuropil of layer III of the young rat somatosensory cortex (hindlimb representation). We have used specific software tools to fully reconstruct 1695 synaptic junctions present in these samples and to accurately quantify the number of synapses per unit volume. These tools also allowed us to determine synapse position and to analyze their spatial distribution using spatial statistical methods. Our results indicate that the distribution of synaptic junctions in the neuropil is nearly random, only constrained by the fact that synapses cannot overlap in space. A theoretical model based on random sequential absorption, which closely reproduces the actual distribution of synapses, is also presented.

Planificación del entrenamiento: salto de longitud

En el presente trabajo, para referirnos al entrenamiento de salto de longitud dividimos la acción en tres áreas para su mejor comprensión y así, obtener un punto de vista del entrenamiento más adecuado. Estas áreas son: Técnica: Movimiento realizado por el cuerpo. Posición de los segmentos corporales y centro de gravedad (CDG) así como su manera de interaccionar con el entorno. Metabólica: Obtención y utilización de energía por parte del organismo. En este caso nos referiremos a la obtención y utilización de energía por parte de las células musculares principalmente. Neuromuscular: Modo de actuación del complejo formado por el sistema nervioso y el sistema muscular. Con ello nos referimos a las manifestaciones de fuerza y tipos de tensión generados por este complejo neuromuscular.

Quantitative fine-structural analysis of olfactory cortical synapses

To determine the extent to which hippocampal synapses are typical of those found in other cortical regions, we have carried out a quantitative analysis of olfactory cortical excitatory synapses, reconstructed from serial electron micrograph sections of mouse brain, and have compared these new observations with previously obtained data from hippocampus. Both superficial and deep layer I olfactory cortical synapses were studied. Although individual synapses in each of the areas—CA1 hippocampus, olfactory cortical layer Ia, olfactory cortical area Ib—might plausibly have been found in any of the other areas, the average characteristics of the three synapse populations are distinct. Olfactory cortical synapses in both layers are, on average, about 2.5 times larger than their hippocampal counterparts. The layer Ia olfactory cortical synapses have fewer synaptic vesicles than do the layer Ib synapses, but the absolute number of vesicles docked to the active zone in the layer Ia olfactory cortical synapses is about equal to the docked vesicle number in the smaller hippocampal synapses. As would be predicted from studies on hippocampus that relate paired-pulse facilitation to the number of docked vesicles, the synapses in layer 1a exhibit facilitation, whereas the ones in layer 1b do not. Although hippocampal synapses provide as a good model system for central synapses in general, we conclude that significant differences in the average structure of synapses from one cortical region to another exist, and this means that generalizations based on a single synapse type must be made with caution.

Profound misregulation of muscle-specific gene expression in facioscapulohumeral muscular dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder characterized by an insidious onset and progressive course. The disease has a frequency of about 1 in 20,000 and is transmitted in an autosomal dominant fashion with almost complete penetrance. Deletion of an integral number of tandemly arrayed 3.3-kb repeat units (D4Z4) on chromosome 4q35 is associated with FSHD but otherwise the molecular basis of the disease and its pathophysiology remain obscure. Comparison of mRNA populations between appropriate cell types can facilitate identification of genes relevant to a particular biological or pathological process. In this report, we have compared mRNA populations of FSHD and normal muscle. Unexpectedly, the dystrophic muscle displayed profound alterations in gene expression characterized by severe underexpression or overexpression of specific mRNAs. Intriguingly, many of the deregulated mRNAs are muscle specific. Our results suggest that a global misregulation of gene expression is the underlying basis for FSHD, distinguishing it from other forms of muscular dystrophy. The experimental approach used here is applicable to any genetic disorder whose pathogenic mechanism is incompletely understood.

Activity-dependent regulation of synaptic clustering in a hippocampal culture system

Currently, there is a limited understanding of the factors that influence the localization and density of individual synapses in the central nervous system. Here we have studied the effects of activity on synapse formation between hippocampal dentate granule cells and CA3 pyramidal neurons in culture, taking advantage of FM1–43 as a fluorescent marker of synaptic boutons. We observed an early tendency for synapses to group together, quickly followed by the appearance of synaptic clusters on dendritic processes. These events were strongly influenced by N-methyl-d-aspartic acid receptor- and cyclic AMP-dependent signaling. The microstructure and localization of the synaptic clusters resembled that found in hippocampus, at mossy fiber synapses of stratum lucidum. Activity-dependent clustering of synapses represents a means for synaptic targeting that might contribute to synaptic organization in the brain.

Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: Required role for the MuSK ectodomain?

Formation of the neuromuscular junction (NMJ) depends upon a nerve-derived protein, agrin, acting by means of a muscle-specific receptor tyrosine kinase, MuSK, as well as a required accessory receptor protein known as MASC. We report that MuSK does not merely play a structural role by demonstrating that MuSK kinase activity is required for inducing acetylcholine receptor (AChR) clustering. We also show that MuSK is necessary, and that MuSK kinase domain activation is sufficient, to mediate a key early event in NMJ formation—phosphorylation of the AChR. However, MuSK kinase domain activation and the resulting AChR phosphorylation are not sufficient for AChR clustering; thus we show that the MuSK ectodomain is also required. These results indicate that AChR phosphorylation is not the sole trigger of the clustering process. Moreover, our results suggest that, unlike the ectodomain of all other receptor tyrosine kinases, the MuSK ectodomain plays a required role in addition to simply mediating ligand binding and receptor dimerization, perhaps by helping to recruit NMJ components to a MuSK-based scaffold.