The altar and the throne alliance. The Russian Orthodox Church vs. the government in Russia. OSW STUDIES 54, 2016-01-04

The Russian Orthodox Church Moscow Patriarchate (ROC), the largest religious community in Russia, plays an essential role in the process of the cultural and national self-identification of the Russian people. Being a socio-political institution with a centuries-long history, it possesses great symbolic capital and enjoys public respect, which has been used for political purposes. Since Vladimir Putin regained the presidency in 2012, in order to strengthen the political regime in Russia the Kremlin has begun to extensively draw upon conservative ideology and promote the traditional moral and social values which the Church is viewed as the guardian of. This has resulted in establishing closer relations between the secular government and the ROC, as well as in a greater engagement of ROC hierarchs and organisations in domestic and foreign policy issues. This situation exposes the ROC to criticism for being excessively involved in politics, and in the longer term, to the risks linked to potential destabilisation of the governmental system in Russia.

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.

BACKGROUND The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues. The objective of this study was to identify nucleus pulposus-derived progenitor cells (NPPC) and examine their potential in regenerative medicine in vitro. METHODS Nucleus pulposus cells (NPC) were obtained from 1-year-old bovine coccygeal discs by enzymatic digestion and were sorted for the angiopoietin-1 receptor Tie2. The obtained Tie2- and Tie2+ fractions of cells were differentiated into osteogenic, adipogenic, and chondrogenic lineages in vitro. Colony-forming units were prepared from both cell populations and the colonies formed were analyzed and quantified after 8 days of culture. In order to improve the preservation of the Tie2+ phenotype of NPPC in monolayer cultures, we tested a selection of growth factors known to have stimulating effects, cocultured NPPC with IVD tissue, and exposed them to hypoxic conditions (2 % O2). RESULTS After 3 weeks of differentiation culture, only the NPC that were positive for Tie2 were able to differentiate into osteocytes, adipocytes, and chondrocytes as characterized by calcium deposition (p < 0.0001), fat droplet formation (p < 0.0001), and glycosaminoglycan content (p = 0.0095 vs. Tie2- NPC), respectively. Sorted Tie2- and Tie2+ subpopulations of cells both formed colonies; however, the colonies formed from Tie2+ cells were spheroid in shape, whereas those from Tie2- cells were spread and fibroblastic. In addition, Tie2+ cells formed more colonies in 3D culture (p = 0.011) than Tie2- cells. During expansion, a fast decline in the fraction of Tie2+ cells was observed (p < 0.0001), which was partially reversed by low oxygen concentration (p = 0.0068) and supplementation of the culture with fibroblast growth factor 2 (FGF2) (p < 0.0001). CONCLUSIONS Our results showed that the bovine nucleus pulposus contains NPPC that are Tie2+. These cells fulfilled formally progenitor criteria that were maintained in subsequent monolayer culture for up to 7 days by addition of FGF2 or hypoxic conditions. We propose that the nucleus pulposus represents a niche of precursor cells for regeneration of the IVD.

Partners of the Alliance.

At head of title: 89th Congress, 2d session. Subcommittee print.

U. S. foreign aid and the Alliance for progress : proposed fiscal year 1971 program /

"An excerpt from the Agency for International Development's program presentation to the Congress outlining the President's foreign aid request for fiscal year ... 1971."

U.S. aid operations in Latin America under the Alliance for Progress ; thirty-sixth report by Committee on Government Operations.

"Aug. 5, 1968"

The Alliance for Progress; a hemispheric response to a global threat.

Mode of access: Internet.

United States-Latin American relations: some observations on the operation of the Alliance for Progress, the first six months.

At head of title: 87th Cong., 2d sess. Committee print.

A review of Alliance for Progress goals : a report by the Bureau for Latin America, Agency for International Development.

"March 1969."

Alliance for Progress : an American partnership /

Cover title.

North Atlantic Treaty Organization : an alliance of shared values : report of the Delegation to NATO Countries--1982, of the Committee on Armed Services, House of Representatives, Ninety-seventh Congress, second session.

Mode of access: Internet.