Environmental geochemical studies of selected mineral deposits in Wrangell-St. Elias National Park and Preserve, Alaska /

Mode of access: Internet.

The general history of the Christian Church, from her birth to her final triumphant state in heaven: chiefly deduced from the Apocalypse of St. John, the apostle and evangelist.

Mode of access: Internet.

Memorials of the parochial church, the collegiate chantry, and the chapel of St. Mary : commonly called Mortimer's Chapel, in the Parish of Attleborough, in the county of Norfolk, together with some account of the services used at the consecration of churches from the Anglo-Saxon to the present time /

Includes bibliographical references.

Practical pharmacy and prescribing for students of medicine : being the course in use at St. Bartholomew's Hospital /

Interleaved.

Die bergpredigt Christi nach St. Matthäus. Homiletisch bearbeitet und in vier und zwanzig predigten dargestellt

Mode of access: Internet.

An interpreter of war, Habakkuk : addresses delivered in St. Margaret's Westminster.

Mode of access: Internet.

St. Barbara, die schutzheilige der bergleute und der artillerie, und ihre darstellung in der kunst ...

Bibliographical foot-notes.

A voyage to Senegal ; or, historical, philosophical, and political memoirs, relative to the discoveries ... of Europeans in the Atlantic Ocean ... to which is added an account of a journey from Isle St. Louis to Galam

by J. P. L. Durand

West Nile and St. Louis encephalitis virus antibody seroconversion, prevalence, and persistence in naturally infected pig-tailed macaques (Macaca nemestrina)

Pig-tailed macaques (Macaca nemestrina) naturally infected with West Nile virus were monitored from 1999 to 2005 to determine virus-specific antibody seroconversion, prevalence, and persistence. Antibodies persisted for up to 36 months, as detected by epitope-blocking enzyme-linked immunosorbent and hemagglutination inhibition assays. Exposure to cocirculating St. Louis encephalitis virus was evaluated by Western blotting and immunofluorescence assays.

HOCl-modified phosphatidylcholines induce apoptosis and redox imbalance in HUVEC-ST cells

Electrophilic attack of hypochlorous acid on unsaturated bonds of fatty acyl chains is known to result mostly in chlorinated products that show cytotoxicity to some cell lines and were found in biological systems exposed to HOCl. This study aimed to investigate more deeply the products and the mechanism underlying cytotoxicity of phospholipid-HOCl oxidation products, synthesized by the reaction of HOCl with 1-stearoyl-2-oleoyl-, 1-stearoyl-2-linoleoyl-, and 1-stearoyl-2-arachidonyl-phosphatidylcholine. Phospholipid chlorohydrins were found to be the most abundant among obtained products. HOCl-modified lipids were cytotoxic towards HUVEC-ST (endothelial cells), leading to a decrease of mitochondrial potential and an increase in the number of apoptotic cells. These effects were accompanied by an increase of the level of active caspase-3 and caspase-7, while the caspase-3/-7 inhibitor Ac-DEVD-CHO dramatically decreased the number of apoptotic cells. Phospholipid-HOCl oxidation products were shown to affect cell proliferation by a concentration-dependent cell cycle arrest in the G/G phase and activating redox sensitive p38 kinase. The redox imbalance observed in HUVEC-ST cells exposed to modified phosphatidylcholines was accompanied by an increase in ROS level, and a decrease in glutathione content and antioxidant capacity of cell extracts. © 2014 Elsevier Inc. All rights reserved.

36 monocyte subpopulations counts and associations with global longitudinal strain in st-elevation myocardial infarction patients with normal ejection fraction

Introduction - Monocytes, with 3 different subsets, are implicated in the initiation and progression of the atherosclerotic plaque contributing to plaque instability and rupture. Mon1 are the “classical” monocytes with inflammatory action, whilst Mon3 are considered reparative with fibroblast deposition ability. The function of the newly described Mon2 subset is yet to be fully described. In PCI era, fewer patients have globally reduced left ventricular ejection fraction post infarction, hence the importance of studying regional wall motion abnormalities and deformation at segmental levels using longitudinal strain. Little is known of the role for the 3 monocyte subpopulations in determining global strain in ST elevation myocardial infarction patients (STEMI). Conclusion In patients with normal or mildly impaired EF post infarction, higher counts of Mon1 and Mon2 are correlated with GLS within 7 days and at 6 months of remodelling post infarction. Adverse clinical outcomes in patients with reduced convalescent GLS were predicted with Mon1 and Mon2 suggestive of an inflammatory role for the newly identified Mon2 subpopulation. These results imply an important role for monocytes in myocardial healing when assessed by subclinical ventricular function indices. Methodology - STEMI patients (n = 101, mean age 64 ± 13 years; 69% male) treated with percutaneous revascularisation were recruited within 24 h post-infarction. Peripheral blood monocyte subpopulations were enumerated and characterised using flow cytometry after staining for CD14, CD16 and CCR2. Phenotypically, monocyte subpopulations are defined as: CD14++CD16-CCR2+ (Mon1), CD14++CD16+CCR2+ (Mon2) and CD14+CD16++CCR2- (Mon3). Phagocytic activity of monocytes was measured using flow cytometry and Ecoli commercial kit. Transthoracic 2D echocardiography was performed within 7 days and at 6 months post infarct to assess global longitudinal strain (GLS) via speckle tracking. MACE was defined as recurrent acute coronary syndrome and death. Results - STEMI patients with EF ≥50% by Simpson’s biplane (n = 52) had GLS assessed. Using multivariate regression analysis higher counts of Mon1 and Mon 2 and phagocytic activity of Mon2 were significantly associated with GLS (after adjusting for age, time to hospital presentation, and peak troponin levels) (Table 1). At 6 months, the convalescent GLS remained associated with higher counts of Mon1, Mon 2. At one year follow up, using multivariate Cox regression analysis, Mon1 and Mon2 counts were an independent predictor of MACE in patients with a reduced GLS (n = 21)

A postcolonial queer analysis of aboriginal queer clients' experiences of health care services in St. John's, Newfoundland

This thesis examines the gaps between health care services aimed at Aboriginal queer individuals living in St. John’s, Newfoundland and their health care needs. I used a multi-methods research design that includes interviews and demographic surveys, unobtrusive observation and qualitative content analysis. I conducted semi-structured interviews with institutional representatives from selected health related organizations – Eastern Health, Planned Parenthood Newfoundland and Labrador, the AIDS Committee of Newfoundland and Labrador, and St. John’s Native Friendship Center; as well as a transgender activist and three people who identify as Aboriginal and queer. I conducted observational research at two public seminars on Aboriginal people and health. Finally, I carried out qualitative content analysis of organizational reports and webpages of the selected community organizations. Using a postcolonial queer framework that analyzes how Newfoundland and Labrador’s colonial history is reflected in current health care realities I argue that the lack of appropriate services and culturally insensitive delivery of services reproduce the historical marginalization of an already vulnerable group.

Building connections: political participation, social capital and the built environment in St. John's, Newfoundland

How does where we live affect how we live? Do characteristics of the built environment affect the civic and social lives of the people living there? This study examines these questions at the neighbourhood scale in the Canadian city of St. John's, Newfoundland. To do so, it combines data from a survey measuring respondents' social capital (defined as a combination of social participation, social trust, and civic participation) and a "built environment audit" that records the built characteristics of each respondent's neighbourhood. The study finds a significant, positive relationship between the walkability of a neighbourhood and the social capital of the people living there. This relationship is driven primarily by the effect of the built environment on voluntary participation and relationships with neighbours. The study also tests several methods of measuring walkability, and finds that an objective measure based on street geometry is the best predictor of social capital.

The current state of /L/ allophony in St. John's English

This project examines the use and evaluation of light post-vocalic /l/ in St. John's, Newfoundland. The city, which was primarily settled by the Irish, traditionally did not conform to the Standard Canadian pattern of /l/ allophony. That is, it was reported to have light /l/ in all positions, in contrast to Canadian English, which has dark /l/ in codas and light /l/ in onsets (Clarke 2012). There have been, however, several major social and economic changes in Newfoundland since the mid-twentieth century, which have impacted local dialects (Clarke 2010). In terms of postvocalic /l/, data collected by Clarke in St. John's in the 1980s shows that the light variant is declining in use and being replaced by the dark variant, and that little overt awareness is accompanying this change (2012). This study addresses the decline and awareness of this feature, through production and perception experiments, respectively. This work follows that of Clarke in that it looks at younger age groups that have been born since Clarke's study was conducted in the early 1980s. The results of these experiments suggest that the light post-vocalic /l/ has continued its decline in St. John's English, and that the dark variant is a stable norm. In fact, it is light /l/ in initial position that is experiencing social variation, in that younger speakers are using darker /l/s in this position than their older counterparts. Women, though they display a more standard /l/ allophony pattern overall than men, also show more dramatic initial-/l/ darkening in apparent time. Additionally, there is a significant style shift between word list and interview tasks in this position. The perception experiment shows that there is awareness and stigma associated with the light variant in coda, which could extend to light /l/s in general.