Ação antiúlcera do citral em modelos experimentais in vivo: análise do envolvimento do óxido nítrico, muco aderido e grupamentos sulfidrílicos na proteção da mucosa

As úlceras gástricas, além de representarem eventos patológicos comuns na clínica médica, são atualmente consideradas importantes desafios para a terapêutica, à medida que o tratamento e/ou prevenção dessa doença ainda apresentam limitações, como os efeitos adversos e a baixa qualidade de cicatrização. Outro grande problema é a difícil acessibilidade às terapias disponíveis pela população de baixa renda, devido ao seu alto custo. Considerando a problemática abordada, e levando em consideração que estudos têm mostrado que terpenóides têm apresentado atividade antiúlcera bastante significativa, propusemos investigar o efeito gastroprotetor do monoterpeno Citral em úlceras gástricas experimentais induzidas tanto por etanol quanto por antiinflamatórios não esteroidais (utilizando a Indometacina como agente indutor das ulcerações), bem como avaliar seu efeito cicatrizante. O Citral mostrou ser gastroprotetor frente ao agente lesivo etanol, a partir da dose de 25 mg/kg, em uma relação dose-dependente quando administrado oralmente, sendo mais potente do que a Carbenoxolona, utilizada como controle positivo, a partir de uma dose duas vezes menor [dose de 50 mg/kg, na qual o Citral apresentou 98 % de proteção em relação ao controle negativo (Tween 80 a 8%), contra 85 % de proteção proporcionada pela Carbenoxolona na dose de 100 mg/kg]. No entanto, no modelo de indução de úlceras gástricas por Indometacina o Citral mostrou um efeito dual, ao passo que em doses intermediárias (25 e 50 mg/kg) apresentou efeito gastroprotetor, e em doses extremas (100 e 200 mg/kg) apresentou uma significativa potencialização das lesões, permitindo assim a hipótese de um possível efeito antiinflamatório e/ou antinociceptivo nessas doses. Também foi verificado seu efeito cicatrizante na dose de 25 mg/kg, sendo tão eficaz quanto o Lansoprazol (controle positivo)... (Resumo completo, clicar acesso eletrônico abaixo)

Implicações federativas da emenda Ibsen Pinheiro

Since it was proposed, the Ibsen Pinheiro amendment has given rise to a huge debate in Brazilian society. This amendment proposes to share the revenue generated by royalties and special participations from offshore oil drilling between all municipalities and states, using for this the states and municipalities participation funds. This new distribution is a great rupture with the current model, which mandates that these resources should only be distributed to producing municipalities and states. Since the new proposal affects all offshore operations, and not only those in the new pre-salt areas, the producing municipalities and states would face an immediate loss of revenue in the scale of billions of reais. This study's objective is to analyze the validity of the criteria of redistribution of the government participations proposed by the Ibsen amendment. In this sense, we present the current Brazilian government participation model, focusing on the overfinancing of subnational spheres generated by this model, and compare it to a distribution simulation using the Ibsen amendment criteria. This comparison shows that the current beneficiaries would face a significant loss of revenue, and a distribution that favors the poorest regions of the country, consequence of the states and municipalities participation funds use. The study's last part discusses the various arguments in favor and against the amendment, especially those of constitutional character, most of which are contrary to the Ibsen amendment

Análise dos impactos do Programa Bolsa Família: redistribuição de renda ou assistencialismo?

Esta monografia trata da questão do Programa Bolsa Família desenvolvido pelo governo Luís Inácio Lula da Silva. O objetivo é analisar se o programa tem capacidade de reduzir a pobreza no país. Esta dividida em três capítulos. O primeiro aborda a questão da pobreza no Brasil, apontando em dados qual é a magnitude desta. O segundo capítulo expõe o programa apontando as origens, características e o debate acadêmico. Por fim o terceiro capitulo faz uma análise do impacto do programa e as possíveis possibilidades de ação deste como política social de redução da pobreza

Modelos de tratamento para adenocarcinomas de próstata tratados por radioterapia conformacional 3D

Radiotherapy is a branch of medical physics related to the treatment of malignant neoplasm, being an important instrument in the fight against cancer, when combined with the effort of a multidisciplinary team, composed of, physicians, physicists, nurses and technicians. Every year more than 3.5 million new cases of cancer are recorded in the world, being the prostate cancer responsible for approximately 25% of this amount (INCA and IARC, 2008). In this type of cancer, radiotherapy is a method indicated for treatement. The technological advance in this area over years has allowed a greater accuracy in the tumor location, more conformation of the radiation beam around the tumor, reducing the dose in healthy tissues and a consequent dose increase on treatment (Bedford et al., 1999). A radiotherapy planning, in which the physicist develops an important role, is composed of several steps, including choosing the best configuration of treatment beams. This choice has a close relationship with success of therapy and is critical to achieve the best distribution of dose inside the tumor and expose the least as possible the healthy tissue to radiation. In this work, two options for setting up camps in the first phase in a treatment of prostate cancer were simulated in computer planning: 4 fields orthogonal or “Box” with gantry angles in 00, 1800, 2700 e 90° and 4 fields angled or “X” (1350, 450, 3150 e 2250). The percentage of the rectal volume exposed to 40, 50, 60, 72 and 76 Gy should be limited to 60, 50, 25, 15 and 5% respectively (Greco et al., 2003). The femoral toxicity have limited dose by 70% of the total dose prescribed in a prostate treatment (Bedford et al., 1999). The planning of 27 patients with prostate adenocarcinoma submitted to 3D conformal radiotherapy were accompanied. As a result, it was assessed that the best TCP (tumor control probability)... (Complete abstract click electronic access below)

Da questão agrária brasileira: uma análise sobre o debate da década de 60 e 70

This monograph object of analysis is the agriculture modernization in Brazil between 1960 and 1980, highlighting the discussion of the economic and politic ideas around the Brazilian agrarian question. The first parte presents an introduction about this issue and the theoretical positions, as well as social and economic implications for the development of the productive forces on rural areas. Nevertheless, reflections of its development to the economy as a whole, highlighting the way the income distribution and concentration was realized. On the second part its presented the agriculture modernization Project on the centralized militar government point of view, by the propositions of that time Agriculture Minister, Antônio Delfim Netto. The approach is made through the proposals precreeded by the Rural Worker Statute and the Land Statute, before the Military Coup, with its news counterpoints settled in law by the Agriculture Modernization Project installed in 1964; the concessions of funding grants and subsidized credits; the relationship between the authoritarian State and the militarization of the land conflicts. The third part deals with the salary dinamics, income and profit on the modernized rural economy created by the agroindustrial productions system. Lastly the conclusion cross the economic and social results of the agrarian question evolution, to the Brazilian agriculture modernization on income distribution

Modelos matemáticos e computacionais em dengue

This work was developed starting the study of traditionals mathematical models that describe the epidemiology of infectious díseases by direct or indirect transmission. We did the classical approach of equilibrium solutions search, its analysis of stability analytically and by numerical solutions. After, we applied these techniques in a compartimental model of Dengue transmission that consider the mosquito population (susceptible vector Vs and 'infected vector VI), human population (suseeptíble humans S, infected humans I and recovered humans R) and just one sorotype floating in this population. We found the equilibrium solutions and from their analises, it was possible find the reprodution rate of dísease and which define if the disease will be endemic or not in the population.- ext, we used the method described a..~, [1] to study the infíuence of seasonalíty at vírus transmission, when it just acts on one of rates related with the vector. Lastly, we made de modeling considering the periodicity of alI rates, thereby building, a modeI with temporal dependence that permits to study periodicity of transmission through of the approach of parametrical ressonance and genetic algorithm

Aplicação de produtos fitossanitários na cultura dos citros utilizando pulverizador envolvente

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Métodos econométricos para a análise do índice de inflação no Brasil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Planejamento de reativos em sistemas elétricos de potência multi-área através de modelos estocásticos

Pós-graduação em Engenharia Elétrica - FEIS

Heurística especializada aplicada na alocação ótima de bancos de capacitores em sistemas de distribuição radial

Pós-graduação em Engenharia Elétrica - FEIS

Condição periodontal, perda dentária e diferenças socioeconômicas em adultos e idosos brasileiros

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Soluções numéricas de Equações Diferenciais Fracionária e Ordinária para o cálculo da distribuição da concentração em um sistema de compartimento

The purpose of this work was the study of numerical methods for differential equations of fractional order and ordinary. These methods were applied to the problem of calculating the distribution of the concentration of a given substance over time in a given physical system. The two compartment model was used for representation of this system. Comparison between numerical solutions obtained were performed and, in particular, also compared with the analytical solution of this problem. Finally, estimates for the error between the solutions were calculated

Desenvolvimento econômico e desigualdade social: um estudo sobre os aspectos sociais presentes na obra de Raúl Prebisch

This study aims to conduct an analysis on the social aspects present in the works of the Argentine economist Raúl Prebisch (1901-1986). Based on the author's research on the economic development of the peripheral countries, it will be demonstrated how the social and economic factors have interconnected in the developmental theory of the peripheral worldwide economy. To achieve this goal, the six works of Prebisch considered essentials by Economic Commission for Latin America and the Caribbean (ECLAC) were used as main bibliographic axis. Such texts are: Introduction to Keynes, The Economic Development of Latin America and Its Principal Problems, Economic development or monetary stability: the false dilemma, Towards a Dynamic Development Policy for Latin America, .Change and Development: Latin America's Great Task, Capitalismo periférico: crisis y transformación, Five stages in my thinking on development. Firstly the topics essential to economic development according to the author will be exposed, such as industrialization of peripheral countries as a means of raising the income of masses and the way it should be coordinated beyond the theoretical author's choice on historical events, the evolution of the deterioration of terms of trade between peripheral and central countries and the need for productivity gains to increase the income of the worker. Afterwards it will be exposed how such terms align with social inequalities and which definitions are incorporated by the author on the subject

Monitoramento de cultivos submersos de linhagens de Streptomyces clavuligerus para a quantificação de distribuição de fluxos metabólicos

Pós-graduação em Biotecnologia - IQ

Alocação ótima de chaves de interconexão nas redes de distribuição de energia elétrica

Pós-graduação em Engenharia Elétrica - FEIS