[14 juillet 1919, Hôtel de ville et place de l'Hôtel de ville de Paris décorés et illuminés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 54999

[14 juillet 1919, Hôtel de ville et place de l'Hôtel de ville de Paris décorés et illuminés] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55000

[14 juillet 1919, un bal populaire dans Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55001

[14 juillet 1919, un bal populaire dans Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55002

I-380 dedication : Boyson Road to Iowa 101, August 14, 1984.

Program from the dedication of Boyson Road to Iowa 101 on Interstate I-380.

Iowa Animal Industry News, 2013, Vol. 14, no. 1

Newsletter produced by Department of Agriculture and Land Stewardship about the animal industry in Iowa. Previously titled Animal Industry News.

Iowa Workforce Monthly, March 2010, Issue 14

Highlights: * Iowa Workforce Development Director Elisabeth Buck and Deputy Director Joe Walsh recently visited a number of IowaWORKS offices in Eastern Iowa as part of a summer tour........................................pg. 2 * Amber Connolly was recently awarded the Iowa Association of Workplace Professionals (IAWP) individual award for Outstanding Specialized Customer Service...............pg. 2 * Iowa Workforce Development has partnered with Iowa’s Community Colleges to implement Iowa’s National Career Readiness Certificate (NCRC).................pg. 3 * O*NET is an occupational information network developed under the sponsorship of the U.S. Department of Labor/Employment and Training Administration.....................pg. 3

Myeloid-related proteins 8 and 14 contribute to monosodium urate monohydrate crystal-induced inflammation in gout.

OBJECTIVE: Monosodium urate monohydrate (MSU) crystal-induced interleukin-1β (IL-1β) secretion is a critical factor in the pathogenesis of gout. However, without costimulation by a proIL-1β-inducing factor, MSU crystals alone are insufficient to induce IL-1β secretion. The responsible costimulatory factors that act as a priming endogenous signal in vivo are not yet known. We undertook this study to analyze the costimulatory properties of myeloid-related protein 8 (MRP-8) and MRP-14 (endogenous Toll-like receptor 4 [TLR-4] agonists) in MSU crystal-induced IL-1β secretion and their relevance in gout. METHODS: MRP-8/MRP-14 was measured in paired serum and synovial fluid samples by enzyme-linked immunosorbent assay (ELISA) and localized in synovial tissue from gout patients by immunohistochemistry. Serum levels were correlated with disease activity, and MSU crystal-induced release of MRPs from human phagocytes was measured. Costimulatory effects of MRP-8 and MRP-14 on MSU crystal-induced IL-1β secretion from phagocytes were analyzed in vitro by ELISA, Western blotting, and polymerase chain reaction. The impact of MRP was tested in vivo in a murine MSU crystal-induced peritonitis model. RESULTS: MRP-8/MRP-14 levels were elevated in the synovium, tophi, and serum of patients with gout and correlated with disease activity. MRP-8/MRP-14 was released by MSU crystal-activated phagocytes and increased MSU crystal-induced IL-1β secretion in a TLR-4-dependent manner. Targeted deletion of MRP-14 in mice led to a moderately reduced response of MSU crystal-induced inflammation in vivo. CONCLUSION: MRP-8 and MRP-14, which are highly expressed in gout, are enhancers of MSU crystal-induced IL-1β secretion in vitro and in vivo. These endogenous TLR-4 ligands released by activated phagocytes contribute to the maintenance of inflammation in gout.

Friday Facts, June 14, 2013, Vol. 177

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.

EPI Update, June 14, 2013

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Quick Reads, May 14, 2013

IDPH Quick Reads is an electronic newsletter produced by the Director’s Office at the Iowa Department of Public Health. IDPH Quick Reads are published every three to four weeks.

Quick Reads, June 14, 2013

IDPH Quick Reads is an electronic newsletter produced by the Director’s Office at the Iowa Department of Public Health. IDPH Quick Reads are published every three to four weeks.

Iowa Crop and Weather Report, June 10, 2013 Vol 13, no.14

Report produced by the The Department of Agriculture and Land Stewardship, Climatology Bureau. Iowa Secretary of Agriculture Bill Northey today commented on the Iowa Crops and Weather report released by the USDA National Agricultural Statistical Service. The report is released weekly from April through October.

Heterogeneity of t(4;14) in multiple myeloma. Long-term follow-up of 100 cases treated with tandem transplantation in IFM99 trials.

One hundred de novo multiple myeloma patients with t(4;14) treated with double intensive therapy according to IFM99 protocols were retrospectively analyzed. The median overall survival (OS) and event-free survival (EFS) were 41.4 and 21 months, respectively, as compared to 65 and 37 for patients included in the IFM99 trials without t(4;14) (P<10(-7)). We identified a subgroup of patients presenting at diagnosis with both low beta(2)-microglobulin <4 mg/l and high hemoglobin (Hb) >/=10 g/l (46% of the cases) with a median OS of 54.6 months and a median EFS of 26 months, respectively, which benefits from high-dose therapy (HDT); conversely patients with one or both adverse prognostic factor (high beta(2)-microglobulin and/or low Hb) had a poor outcome. The achievement of either complete response or very good partial response after HDT was also a powerful independent prognostic factor for both OS and EFS.