The Illinois Department of Public Health, 1877-1977, 100 years : history /

Bibliography: p. 12.

The Boston Academy's Collection of church music : consisting of the most popular psalm and hymn tunes, anthems, sentences, chants, &c., old and new : together with many beautiful pieces, tunes and anthems, selected from the masses and other works of Haydn, Mozart, Beethoven ... and other distinguished composers, arranged and adapted to English words expressly for this work, including, also, original compositions by German, English and American authors.

Includes indexes.

Operator and organizational maintenance manual : generator set, diesel engine, precise power, 100 kw, AC, 120/208V, 240/416V, 3 phase, 60 cycle, at 1800 rpm, 83.3 kw, 120/208V, 240/416V, 3 phase, 50 cycle at 1500 rpm, skid mounted ....

"April 1961."

Tower AB-216/U, tower section set AB-298/U, guy kit MK-99/U, accessory kit MK-100/U, guy kit MK-101/U.

"June 1956."

Operator's manual : truck, lift, fork, gasoline, solid rubber tired wheels, 2,000 lbs capacity, Army model MHE-182, Allis-Chalmers model FT20-24PS-100, FSN 3930-958-3682, Allis-Chalmers model FT20-24PS-127, FSN 3930-958-3683.

"December 1963."

Operator's manual : truck, lift, fork, gasoline, solid-rubber-tired wheels, 2000-pound capacity, Army model MHE-191, Clark model C20B-1632032-100, FSN 3930-781-3857 ....

"October 1964."

Direct support and general support maintenance repair parts and special tools lists : truck, cargo, 1-1/4 ton, 4x4, M880, NSN 2320-00-579-8942, M881, W/28 volt, 60 ampere generating system kit, NSN 2320-00-579-8943, M882, W/28 volt, 60 ampere generating system, and communications kits, NSN 2320-00-579-8957, M883, W/28 volt, 60 ampere generating system, ...

Includes index.

Operator's manual : grader, road, motorized, diesel driven, 12,100 to 14,300 lb pressure at blade, (Huber-Warco model 4D), FSN 3805-542-2995 winterized, FSN 3805-542-2996 nonwinterized.

Includes index.

Operator and organizational maintenance manual including repair parts and special tools list : filter-separator, liquid fuel, 100 gpm, frame mounted (Keene Corp. model 844-5-V-100AL), FSN 4330-491-4957.

"April 1973."

Operator and organizational maintenance manual : tank, steel, vertical, bolted, knockdown, sealed openings, standard bottom and roof, gasoline, oil, or water (type I-pol and potable water, type II-pol and non-potable water), 100 barrel capacity ... 10,000 barrel capacity ....

"May, 1974."

Operation and organizational maintenance : electrical power test sets AN/UPM-93 and AN/UPM-100.

"July 1959."

The Boston Academy's Collection of church music : consisting of the most popular psalm and hymn tunes, anthems, sentences, chants, &c. old and new ... /

Includes index.

Jing chuan wen zai : 100 juan /

Block print.

Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines

There is evidence to suggest that plasma membrane Ca2+-ATPase (PMCA) isoforms are important mediators of mammary gland physiology. PMCA2 in particular is upregulated extensively during lactation. Expression of other isoforms such as PMCA4 may influence mammary gland epithelial cell proliferation and aberrant regulation of PMCA isoform expression may lead or contribute to mammary gland pathophysiology in the form of breast cancers. To explore whether PMCA2 and PMCA4 expression may be deregulated in breast cancer, we compared mRNA expression of these PMCA isoforms in tumorigenic and non-tumorigenic human breast epithelial cell lines using real time RT-PCR. PMCA2 mRNA has a higher level of expression in some breast cancer cell lines and is overexpressed more than 100-fold in ZR-75-1 cells, compared to non-tumorigenic 184135 cells. Although differences in PMCA4 mRNA levels were observed between breast cell lines, they were not of the magnitude observed for PMCA2. We conclude that PMCA2 mRNA can be highly overexpressed in some breast cancer cells. The significance of PMCA2 overexpression on tumorigenicity and its possible correlation with other properties such as invasiveness requires further study. (c) 2005 Elsevier Inc. All rights reserved.

Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives

Tamoxifen is a known hepatocarcinogen in rats and is associated with an increased incidence of endometrial. cancer in patients. One mechanism for these actions is via bioactivation, where reactive metabolites are generated that are capable of binding to DNA or protein. Several metabolites of tamoxifen have been identified that appear to predispose to adduct formation. These include alpha-hydroxytamoxifen, alpha,4-dihydroxytamoxifen, and alpha-hydroxy-N-desmethyltamoxifen. Previous studies have shown that cytochrome P450 (P450) enzymes play an important role in the biotransformation of tamoxifen. The aim of our work was to determine which P450 enzymes were capable of producing a-hydroxylated metabolites from tamoxifen. When tamoxifen (18 or 250,mu M) was used as the substrate, P450 3A4, and to a lesser extent, P450 2D6, P450 2B6, P450 3A5, P450 2C9, and P450 2C19 all produced a metabolite with the same HPLC retention time as alpha-hydroxytamoxifen at either substrate concentration tested. This peak was well-separated from 4-hydroxy-N-desmethyltamoxifen, which eluted substantially later under the chromatographic conditions used. No alpha,4-dihydroxytamoxifen was detected in incubations with any of the forms with tamoxifen as substrate. However, when 4-hydroxytamoxifen (100,mu M) was used as the substrate, P450 2B6, P450 3A4, P450 3A5, P450 1B1, P450 1A1, and P450 2D6 all produced detectable concentrations of a,4-dihydroxytamoxifen. These studies demonstrate that multiple human P450s, including forms found in the endometrium, may generate reactive metabolites in women undergoing tamoxifen therapy, which could subsequently play a role in the development of endometrial cancer.