Multimodal Imaging of Cotton Wool Spots in Branch Retinal Vein Occlusion.

PURPOSE: To describe and follow cotton wool spots (CWS) in branch retinal vein occlusion (BRVO) using multimodal imaging. METHODS: In this prospective cohort study including 24 patients with new-onset BRVO, CWS were described and analyzed in color fundus photography (CF), spectral domain optical coherence tomography (SD-OCT), infrared (IR) and fluorescein angiography (FA) every 3 months for 3 years. The CWS area on SD-OCT and CF was evaluated using OCT-Tool-Kit software: CWS were marked in each single OCT B-scan and the software calculated the area by interpolation. RESULTS: 29 central CWS lesions were found. 100% of these CWS were visible on SD-OCT, 100% on FA and 86.2% on IR imaging, but only 65.5% on CF imaging. CWS were visible for 12.4 ± 7.5 months on SD-OCT, for 4.4 ± 3 months and 4.3 ± 3.4 months on CF and on IR, respectively, and for 17.5 ± 7.1 months on FA. The evaluated CWS area on SD-OCT was larger than on CF (0.26 ± 0.17 mm(2) vs. 0.13 ± 0.1 mm(2), p < 0.0001). The CWS area on SD-OCT and surrounding pathology such as intraretinal cysts, avascular zones and intraretinal hemorrhage were predictive for how long CWS remained visible (r(2) = 0.497, p < 0.002). CONCLUSIONS: The lifetime and presentation of CWS in BRVO seem comparable to other diseases. SD-OCT shows a higher sensitivity for detecting CWS compared to CF. The duration of visibility of CWS varies among different image modalities and depends on the surrounding pathology and the CWS size.

Calcium carbonate vein compositions from drill sites in the Atlantic and Pacific

Chemical (Sr, Mg) and isotopic (d18O, 87Sr/86Sr) compositions of calcium carbonate veins (CCV) in the oceanic basement were determined to reconstruct changes in Sr/Ca and Mg/Ca of seawater in the Cenozoic. We examined CCV from ten basement drill sites in the Atlantic and Pacific, ranging in age between 165 and 2.3 Ma. Six of these sites are from cold ridge flanks in basement <46 Ma, which provide direct information about seawater composition. CCV of these young sites were dated, using the Sr isotopic evolution of seawater. For the other sites, temperature-corrections were applied to correct for seawater-basement exchange processes. The combined data show that a period of constant/low Sr/Ca (4.46 - 6.22 mmol/mol) and Mg/Ca (1.12 - 2.03 mol/mol) between 165 and 30 Ma was followed by a steady increase in Mg/Ca ratios by a factor of three to modern ocean composition. Mg/Ca - Sr/Ca relations suggest that variations in hydrothermal fluxes and riverine input are likely causes driving the seawater compositional changes. However, additional forcing may be involved in explaining the timing and magnitude of changes. A plausible scenario is intensified carbonate production due to increased alkalinity input to the oceans from silicate weathering, which in turn is a result of subduction-zone recycling of CO2 from pelagic carbonate formed after the Cretaceous slow-down in ocean crust production rate.

Geothermometry, ore geochemistry and fluid flow in the Esperanza Vein, Huachocolpa District (Huancavelica, Peru)

The Esperanza Zn-Pb-Ag vein, owned by Compañía de Minas Buenaventura S.A.A., lies over 4000 to 4650 masl in the Western Cordillera of the Peruvian Central Andes. The Esperanza low sulphidation epithermal vein trends ~E-W along 1500 m; it dips to the South and can be followed to 350 m depth. As other veins of the district, like Teresita and Bienaventurada, it is hosted by intermediate to felsic volcanics (andesitic to dacitic compositions) of the Huachocolpa Group (Middle Miocene to Upper Pliocene). The mineralisation occurs mostly as open space filling related to fracture development during the Quechua III deformational event. Main ore minerals are sphalerite, galena, tetrahedrite, pyrite, chalcopyrite and Ag and Pb sulfosalts; quartz, barite and calcite are the main gangue minerals. Current production grades are ~5% Zn, ~8Oz/t Ag, ~3% Pb; usually very low Cu (mean ~0.04%).

Portal Observatorio: El nuevo punto de encuentro de la comunidad IDE

El Portal Observatorio IDE es una plataforma colaborativa online en desarrollo que aspira a convertirse en un destacado punto de encuentro para toda la comunidad IDE. Nace con el fin de conseguir atraer las diversas iniciativas relacionadas con las IDE que se están gestando en la actualidad, contribuyendo así a la concentración, coordinación y monitorización de esfuerzos. Para conseguirlo, se propone una plataforma con una estructura adaptable y dinámica, en la que se invite a los propios usuarios a colaborar en la gestión de su estructura, funcionamiento y alojamiento de contenidos. En el presente artículo se realiza una declaración de los fundamentos e ideas que han llevado a las instituciones implicadas a la creación del Portal Observatorio IDE, se detallan las herramientas tecnológicas empleadas para su programación, las características y utilidades implementadas y los resultados esperados con su puesta en marcha.

Factor analysis for metal grade exploration at Pallancata Vein in Peru

Se investiga la distribución espacial de contenidos metálicos analizados sobre testigos de sondeos obtenidos en las campañas de exploración de la Veta Pallancata. Se aplica el análisis factorial a dicha distribución y a los cocientes de los valores metálicos, discriminando los que están correlacionados con la mineralización argentífera y que sirven como guías de exploración para hallar zonas de potenciales reservas por sus gradientes de variación.Abstract:The metal distribution in a vein may show the paths of hydrothermal fluid flow at the time of mineralization. Such information may assist for in-fill drilling. The Pallancata Vein has been intersected by 52 drill holes, whose cores were sampled and analysed, and the results plotted to examine the mineralisation trends. The spatial distribution of the ore is observed from the logAg/logPb ratio distribution. Au is in this case closely related to Ag (electrum and uytenbogaardtite, Ag3AuS2 ). The Au grade shows the same spatial distribution as the Ag grade. The logAg/logPb ratio distribution also suggests possible ore to be expected at deeper locations. Shallow supergene Ag enrichment was also observed.

AFRICA BUILD Portal: developing a social network of African health researchers and educators

One of the main outputs of the project is a collaborative platform which integrates a myriad of research and learning resources. This article presents the first prototype of this platform: the AFRICA BUILD Portal (ABP 1.0). The ABP is a Web 2.0 platform which facilitates the access, in a collaborative manner, to these resources. Through a usable web interface, the ABP has been designed to avoid, as much as possible, the connectivity problems of African institutions. In this paper, we suggest that the access to complex systems does not imply slow response rates, and that their development model guides the project to a natural technological transfer, adaptation and user acceptance. Finally, this platform aims to motivate research attitudes during the learning process and stimulate user?s collaborations.

Definición del modelo de negocio y plan de marketing para un portal de venta de productos para el bebé

En este documento se presenta el plan de marketing realizado para una empresa de venta online de productos para bebés y padres. Partiendo de una reflexión de qué quiere ser la empresa (Visión, Misión y Valores), y siguiendo la metodología “Go to Market”, detallada a continuación, se realiza un trabajo de estudio de situación, cubriendo todas las fases de dicha metodología, que culmina en un plan de acción que detalla un conjunto de iniciativas cuyo fin último es la mejora operativa de la empresa, y el aumento de ingresos y rentabilidad. ---ABSTRACT---In this document it’s presented the marketing plan done for an online company selling products for babies and parents. Starting with a consideration of what the company wants to be (Vision, Mission and Values), and following “Go to market” methodology, explained below, a status analysis is performed, covering all the stages of the methodology, culminating in an action plan detailing a set of initiatives whose ultimate goal is the operational improvement of the company, and increasing its revenues and profitability.

Sistema de recomendación semántico para la movilidad en el entorno AFRICA BUILD Portal

La Gestión de Recursos Humanos a través de Internet es un problema latente y presente actualmente en cualquier sitio web dedicado a la búsqueda de empleo. Este problema también está presente en AFRICA BUILD Portal. AFRICA BUILD Portal es una emergente red socio-profesional nacida con el ánimo de crear comunidades virtuales que fomenten la educación e investigación en el área de la salud en países africanos. Uno de los métodos para fomentar la educación e investigación es mediante la movilidad de estudiantes e investigadores entre instituciones, apareciendo así, el citado problema de la gestión de recursos humanos. Por tanto, este trabajo se centra en solventar el problema de la gestión de recursos humanos en el entorno específico de AFRICA BUILD Portal. Para solventar este problema, el objetivo es desarrollar un sistema de recomendación que ayude en la gestión de recursos humanos en lo que concierne a la selección de las mejores ofertas y demandas de movilidad. Caracterizando al sistema de recomendación como un sistema semántico el cual ofrecerá las recomendaciones basándose en las reglas y restricciones impuestas por el dominio. La aproximación propuesta se basa en seguir el enfoque de los sistemas de Matchmaking semánticos. Siguiendo este enfoque, por un lado, se ha empleado un razonador de lógica descriptiva que ofrece inferencias útiles en el cálculo de las recomendaciones y por otro lado, herramientas de procesamiento de lenguaje natural para dar soporte al proceso de recomendación. Finalmente para la integración del sistema de recomendación con AFRICA BUILD Portal se han empleado diversas tecnologías web. Los resultados del sistema basados en la comparación de recomendaciones creadas por el sistema y por usuarios reales han mostrado un funcionamiento y rendimiento aceptable. Empleando medidas de evaluación de sistemas de recuperación de información se ha obtenido una precisión media del sistema de un 52%, cifra satisfactoria tratándose de un sistema semántico. Pudiendo concluir que con la solución implementada se ha construido un sistema estable y modular posibilitando: por un lado, una fácil evolución que debería ir encaminada a lograr un rendimiento mayor, incrementando su precisión y por otro lado, dejando abiertas nuevas vías de crecimiento orientadas a la explotación del potencial de AFRICA BUILD Portal mediante la Web 3.0. ---ABSTRACT---The Human Resource Management through Internet is currently a latent problem shown in any employment website. This problem has also appeared in AFRICA BUILD Portal. AFRICA BUILD Portal is an emerging socio-professional network with the objective of creating virtual communities to foster the capacity for health research and education in African countries. One way to foster this capacity of research and education is through the mobility of students and researches between institutions, thus appearing the Human Resource Management problem. Therefore, this dissertation focuses on solving the Human Resource Management problem in the specific environment of AFRICA BUILD Portal. To solve this problem, the objective is to develop a recommender system which assists the management of Human Resources with respect to the selection of the best mobility supplies and demands. The recommender system is a semantic system which will provide the recommendations according to the domain rules and restrictions. The proposed approach is based on semantic matchmaking solutions. So, this approach on the one hand uses a Description Logics reasoning engine which provides useful inferences to the recommendation process and on the other hand uses Natural Language Processing techniques to support the recommendation process. Finally, Web technologies are used in order to integrate the recommendation system into AFRICA BUILD Portal. The results of evaluating the system are based on the comparison between recommendations created by the system and by real users. These results have shown an acceptable behavior and performance. The average precision of the system has been obtained by evaluation measures for information retrieval systems, so the average precision of the system is at 52% which may be considered as a satisfactory result taking into account that the system is a semantic system. To conclude, it could be stated that the implemented system is stable and modular. This fact on the one hand allows an easy evolution that should aim to achieve a higher performance by increasing its average precision and on the other hand keeps open new ways to increase the functionality of the system oriented to exploit the potential of AFRICA BUILD Portal through Web 3.0.