Regulatory T Cells Accumulate in the Lung Allergic Inflammation and Efficiently Suppress T-Cell Proliferation but Not Th2 Cytokine Production

Foxp3(+)CD25(+)CD4(+) regulatory T cells are vital for peripheral tolerance and control of tissue inflammation. In this study, we characterized the phenotype and monitored the migration and activity of regulatory T cells present in the airways of allergic or tolerant mice after allergen challenge. To induce lung allergic inflammation, mice were sensitized twice with ovalbumin/aluminum hydroxide gel and challenged twice with intranasal ovalbumin. Tolerance was induced by oral administration of ovalbumin for 5 consecutive days prior to OVA sensitization and challenge. We detected regulatory T cells (Foxp3(+)CD25(+)CD4(+) T cells) in the airways of allergic and tolerant mice; however, the number of regulatory T cells was more than 40-fold higher in allergic mice than in tolerant mice. Lung regulatory T cells expressed an effector/memory phenotype (CCR4(high)CD62L(low)CD44(high)CD54(high)CD69(+)) that distinguished them from naive regulatory T cells (CCR4(int)CD62L(high)CD44(int)CD54(int)CD69(-)). These regulatory T cells efficiently suppressed pulmonary T-cell proliferation but not Th2 cytokine production.

Capsaicin for post-surgical neuropathic peripheral pain – calculation of allodynia area

Poster apresentado no Congresso O Norte da Anestesia, 19-21 Novembro 2015, Hotel Ipanema Park, Porto, Portugal.

Resistance of metal-mine airways,

At head of title: ... Department of commerce. Herbert Hoover, secretary. Bureau of mines. Scott Turner, director.

The utility of peripheral vision to motor vehicle drivers. Final technical report.

National Highway Traffic Safety Administration, Washington, D.C.

Peripheral vision training for motor vehicle drivers. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Peripheral Interchange Program (PIP) /

Thesis (M. S.)--University of Illinois at Urbana-Champaign.

Aircraft accident report : Overseas National Airways, inc., McDonnell Douglas DC-8-63, N863, Bangor, Maine, June 20, 1973 /

Mode of access: Internet.

Aircraft accident report : Saturn Airways, inc., Lockheed L-382, N14St, Springfield, Illinois, May 23, 1974 /

Mode of access: Internet.

A survey of endangered, threatened, rare, status undetermined, peripheral, and unique mammals of the southeastern national forests and grasslands /

Cover title: Endangered, threatened and unique mammals of the southern national forests.

Public hearing on applications of Air France and British Airways to operate Concorde aircraft in limited commercial service to New York and Washington, Departmental Auditorium, 14th and Constitution Avenue, Washington, D.C., January 5, 1976.

"The hearing in the above-entitled matter convened at 9:30 o'clock a.m. before the Honorable William T. Coleman, Jr., Secretary of Transportation."

A program of charges for the use of the Federal airways system;

Mode of access: Internet.

Peripheral circulation for low-cost central heating in old houses /

Cover title.

How peripheral a phenomenon is it?: On the interaction of DP-internal ellipsis, degree inversion, and islands

Thesis (Ph.D.)--University of Washington, 2016-06