Comparison of Brazilian plants used to treat gastritis on the oxidative burst of helicobacter pylori -stimulated neutrophil

Ten Brazilian medicinal plants used to treat gastritis and ulcers were carefully selected on the basis of ethnopharmacological importance and antiulcerogenic activity previously described. The antioxidant activity of the methanolic extracts was determined in analysis conditions that simulate a real biological activity on inhibition of the oxidative burst induced in neutrophils using Helicobacter pylori as activator, by a luminol-amplified chemiluminescence assay. The extracts, at low concentration (5 g/mL), exhibited a large variation in inhibitory effects of H. pylori-induced oxidative burst ranging from 48% inhibition to inactive, but all extracts, excluding Byrsonima intermedia, had inhibitory activity over 80% at the concentration of 100 g/mL. The total suppressive antioxidant capacity measured as the effective concentration, which represents the extract concentration producing 50% inhibition of the chemiluminescence induced by H. pylori, varies from 27.2 to 56.8 g/mL and was in the following order: Qualea parviflora > Qualea multiflora > Alchornea triplinervia > Qualea grandiflora > Anacardium humile > Davilla elliptica > Mouriri pusa > Byrsonima basiloba > Alchornea glandulosa > Byrsonima intermedia. The main groups of compounds in tested extracts are presented. Differences in the phytochemical profile, quantitatively and qualitatively, of these plants can explain and justify their protective effect on the gastric mucosa caused by the neutrophil-generated ROS that occurs when H. pylori displays its evasion mechanisms. © 2013 Cibele Bonacorsi et al.

Neutrophil dysfunction varies with the stage of canine visceral leishmaniosis

Canine visceral leishmaniosis (CVL) causes a dependent-stage alteration in neutrophil oxidative metabolism. When production of reactive oxygen species (ROS) exceeds the antioxidant capacity of neutrophils, apoptosis is triggered, impairing the viability and function of these cells, which can predispose dogs to infection. However, the uremic condition observed in late-stage CVL can also alter the viability and function of human neutrophils. To more clearly understand this relationship, the apoptosis rate and oxidative metabolism of neutrophils from control dogs (n= 20) were compared to dogs in moderate (n= 15) and very severe (n= 15) stage CVL, classified according to LeishVet Consensus. To assess neutrophil oxidative metabolism, superoxide production was measured using the nitroblue tetrazolium reduction test (NBT) in isolated neutrophils. The apoptosis rate of neutrophils was estimated using the morphological method. Moderate-stage dogs presented increased superoxide production, while dogs with very severe stage CVL presented decreased superoxide production and an increase neutrophil apoptosis rate. Leishmaniosis causes differential neutrophil dysfunction according to disease stage. In moderate stage CVL, increased superoxide production is observed with no change in neutrophil viability. However, in very severe stage CVL, decreased superoxide production and increased apoptosis occur associated with uremia. © 2013 Elsevier B.V.

Migración y urbanización: las barriadas limeñas: un caso de integración a la vida urbana = Migration and urbanization: The barriadas" of Lima: an example of integration into urban life"

Los documentos del Seminario fueron publicados por UNESCO en 1961 con el título: La urbanización en América Latina/Urbanization in Latin America

Problemas económico-sociales sobre migración y urbanización en la ciudad de Esmeraldas, República del Ecuador = Socio-economic problems of migration and urbanization in the town of Esmeraldas, Ecuador

Los documentos del Seminario fueron publicados por UNESCO en 1961 con el título: La urbanización en América Latina/Urbanization in Latin America

Working Group on the Methodology for the Study of International Migration: introductory paper for the meeting

Se detallan los antecedentes del proceso de constitucion del grupo de trabajo sobre la metodologia para el estudio de la migracion internacional y se plantean algunas bases para la discusion en la primera reunion de dicho grupo a realizarse en Helsinki en septiembre de 1978. Se aportan datos sobre la labor desarrollada por el Centro Latinoamericano de Demografia (CELADE) en el estudio de las migraciones internacionales en los paises latinoamericanos. Se inserta la agenda de la reunion de Helsinki.

Dinámica de la población y desarrollo en el Caribe: con especial énfasis en la fertilidad de adolescentes, migración internacional, política de población y planes de desarrollo = Population dynamics and development in the Caribbean: with special emphasis on adolescent fertility, international migration and population policy and development planning

Incluye Bibliografía

Current trends and patterns of female migration: evidence from México

Includes bibliography

Contributions made by ECLAC in the field of international migration from a human rights and development perspective: report of the activities of the Commission, 2012-2013

Includes bibliography

Migration in the Caribbean: what do we know? an overview of data, policies and programmes at the international and regional levels to address critical issues

Includes bibliography

Report of the Expert Group Meeting on Migration, Human Rights and Development in the Caribbean

Includes bibliography

Expert Group Meeting on Migration, Human Rights and Development

Incluye CD-ROM

Migration in the Caribbean: what do we know?: an overview of data, policies and programmes at the international and regional levels to address critical issues

Includes bibliography