Sadducäer und Pharisäer in ihren Beziehungen zu Alexander Jannai und Salome : zweiter Rechenschafts-Bericht der Jüdisch-Literarischen Gesellschaft für die Jahre 1904-1906. Mit einer wissenschaftlichen Beilage

von Bamberger-Hanau

Briefe an Johann Heinrich Merck von Göthe, Herder, Wieland und andern bedeutenden Zeitgenossen : mit Merck's biographischer Skizze

herausgegeben von Karl Wagner

Role of transforming growth factor-α in von Hippel– Lindau (VHL)−/− clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis

Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the majority of sporadic clear cell renal carcinomas (VHL−/− RCC). Loss of VHL protein function is associated with constitutive expression of mRNAs encoding hypoxia-inducible proteins, such as vascular endothelial growth factor. Overproduction of angiogenic factors might explain why VHL−/− RCC tumors are so highly vascularized, but whether this overproduction is sufficient for oncogenesis still remains unknown. In this report, we examined the activity of transforming growth factor-α (TGF-α), another VHL-regulated growth factor. We show that TGF-α mRNA and protein are hypoxia-inducible in VHL−/− RCC cells expressing reintroduced VHL. In addition to its overexpression by VHL−/− RCC cells, TGF-α can also act as a specific growth-stimulatory factor for VHL−/− RCC cells expressing reintroduced wild-type VHL, as well as primary renal proximal tubule epithelial cells, the likely site of origin of RCC. This role is in contrast to those of other growth factors overexpressed by VHL−/− RCC cells, such as vascular endothelial growth factor and TGF-β1, which do not stimulate RCC cell proliferation. A TGF-α-specific antisense oligodeoxynucleotide blocked TGF-α production in VHL−/− RCC cells, which led to the dependence of those cells on exogenous growth factors to sustain growth in culture. Growth of VHL−/− RCC cells was also significantly reduced by a drug that specifically inhibits the epidermal growth factor receptor, the receptor through which TGF-α stimulates proliferation. These results suggest that the generation of a TGF-α autocrine loop as a consequence of VHL inactivation in renal proximal tubule epithelial cells may provide the uncontrolled growth stimulus necessary for the initiation of tumorigenesis.

Anatomie des Frosches / A. Ecker und R. Wiedersheim ; auf Grund eigener Untersuchungen durchaus neu bearbeitet von Ernst Gaupp.

abt. 1

Triennial Catalogue annotated by Jeremy Belknap, 1791

The collection holds a heavily interleaved 1791 Triennial Catalogue annotated, in part, by Jeremy Belknap. A note by Harvard Librarian John Langdon Sibley, on the verso of the flyleaf, indicates a second annotator: "It should be observed that this catalogue is in the handwriting of two persons, Dr. Belknap & probably interlineations & additions by Rev. Dr. [John] Eliot. The interlineing part should not be too confidently relied on for accuracy. J. L. Sibley, April 14, 1848." The volume contains biographical notes, newspaper clippings, excerpts from manuscript and printed sources such as New England's First Fruits, the manuscript memoirs of Charles Chauncey, and John Winthrop's Journal, and a 1795 letter from Isaac Mansfield. In the letter, Mansfield references an item he believed to be written by his grandfather, Ames Cheever (Harvard AB 1707), and briefly describes his grandfather. A list of election sermon orators with dates is also pasted into the inside back cover, along with an obituary of the Rev. John Wales (Harvard AB 1728) from the Boston Post-Boy, March 4, 1765.

Estonia & Latvia, 1791 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Livland nach der Eintheilung Heinrich des Letten : und zu den Zeiten der Bischöffe u. Ordensmeister bis 1562, entworffen von W. C. Friebe ; gezeichnet von J. W. Krause ; gestochen von F. Ramberg. It was published by J. F. Hartknoch, ca. 1791. Scale [ca. 1:880,000]. Covers Estonia and a portion of Latvia. Map in German.The image inside the map neatline is georeferenced to the surface of the earth and fit to the Europe Lambert Conformal Conic coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as drainage, cities and other human settlements, territorial boundaries, shoreline features, and more. Relief shown by hachures.This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Hamburg, Germany, 1791 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Grundriss der Kayserl. freien Reichs und Handels stadt Hamburg nebst dem auf Königl. : Danischen gebiet daran liegenden Altona einen hochpreislichen Senat, gehorsamst zugeeignet von F.A. von Lawrence, Lieutenant ; gestochen von T.A. Pingeling. It was published in 1791. Scale [ca. 1:5,600]. Map in German. Covers Hamburg, Germany. The image inside the map neatline is georeferenced to the surface of the earth and fit to the WGS84 UTM Zone 32N coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, fortification, ground cover, and more. Relief is shown by hachures. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

General Charte der Laender Zwischen dem Schwarzen und Caspischen Meere: Circassien, Georgien, Armenien, Wüste von Astrachan und Caucasus hauptsoechlich die Grosse und Kleine Kabarda

Nach Russischen und and Handschriften entworsen Strasburg bey Joh. Georg Treuttel ; I. P. Kremer delin ; B. F. Leizelt sc.

Interaktive Visualisierung von Querbeziehungen in XML-Daten mit D3.js

[s.c.]

Beschreibung der groszen Orgel der Marienkirche zu Wismar sowie der groszen Orgel des Domes und der St. Martinikirche zu Halberstadt : ein Beitrag zur Beleuchtung und Würdigung der eigenthümlichen Ansichten und Grundsätze des Herrn Musikdirectors Wilke zu Neu-Ruppin in Bezug auf die Orgelbaukunst von Ferdinand Baake.

Contains history and description of organs built by Friedrich Schulze, David Beck, Josef Wiedemann, and Johann Gottlob Töpfer.

Geschichte der Revolutionen von niederla ndischen Aufstand bis zum Vorabend der franzosi schen Revolution.

Mode of access: Internet.

Das politische Gedicht auf die europäischen Ereignisse von 1854 : mit einem Anhang aus dem "Tagebuch eines Schriftstellers" /

Mode of access: Internet.

Der Christus von Wien. Roman.

Mode of access: Internet.

Die Kunst der Fingerfertigkeit, op. 740. L'art de delier les doigts, op.699. Revidierte Ausg. von Adolf Ruthardt.

Mode of access: Internet.

Die Behandlung und Verwertung von Klärschlamm,

"Verzeichnis der benutzten literatur": p. [vii]-viii.