963 resultados para Imidazo[1,5-a]azines


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6. Vorlesungen 1. - 5. mit dem Titel "Society and Reason". a) Typoskript mit handschriftlichen Randbemerkungen von Theodor W. Adorno, 139 Blatt b) Typoskript, 139 Blatt; 7. Teilstück, Typoskript mit eigenhändigen Korrekturen, 1 Blatt; 8. Eigenhändige Notizen, 4 Blatt; 9. Stichworte zu den Vorlesungen I-III. Typoskript mit eigenhändigen Ergänzungen, 2 Blatt a) Einladungskarte zur Vorlesungsreihe "Society and Reason". Als Typoskript vervielfältigt, 1 Blatt b) Gliederung. Typoskript, 1 Blatt; 10. "Über Probleme des wissenschaftlichen Stils". Reaktion auf ein Schriftstück (aus einem Brief an Friedrich Pollock). a) Typoskript, datiert: 28.11.1943, 3 Blatt b) Max Horkheimer: 1 Brief an Friedrich Pollock, ohne Ort, 28.11.1943, 5 Blatt; 11. Columbia University, New York: 1 Brief (Abschrift) an Max Horkheimer, New York, 5.3.1943, und Stichworte zu den Vorlesungen, 2 Blatt; 12. Zeitungsausschnitt, 1 Blatt.;

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"The Aftermath of National Socialism. On the Cultural Aspects of the Collapse of National Socialism". Vorlesungsreihe des Instituts für Sozialforschung, März 1945; 1. Vorlesungsankündigung und Typoskripte der Beiträge von: Theodor W. Adorno, "The Fate of the Arts" (= "What National Socialism Has Done to the Arts"); Frederick Pollock, "Prejudice and the Social Classes"; Leo Löwenthal, "The Aftermath of Totalitarian Terror". Bibliographie, Typoskripte, geheftet, mit eigenhändiger Korrektur von Frederick Pollock, 93 Blatt; 2. Vorlesungsankündigung, als Typoskript vervielfältigt, 1 Blatt; 3. Max Horkheimer: "Totalitarism and the Crisis of European Culture". Eigene Notizen zur Vorlesung, 3 Blatt; 4. Theodor W. Adorno: Notizen zur Vorlesungsreihe. Typoskript, 2 Blatt; Max Horkheimer: "National Socialism and Philosophy". Seminar Frühjahr 1945; 1. Protokolle zu den Sitzungen vom 5.2, 24.4., 1.5. und 8.5.1945. Typoskript mit eigenhändiger Korrektur, 16 Blatt; 2. Dasselbe. Gebunden, 16 Blatt; 3. Eigenhändige Notizen, 8 Blatt; Max Horkheimer: "The Idea of Philosophy". Vorlesung Winter 1945/46; 1. Eigenhändige Notizen, 3 Blatt; 2. Eigenhändige Notizen, 4 Blatt; 3. Eigenhändige Notizen, 2 Blatt; 4. Abschriften aus Werken unter anderem von Friedrich von Bezold, Karl Lamprecht, Richard Pietchman, Leopold von Ranke, Edwin R.A. Seligman. Typoskripte, 8 Blatt; 5. Paul Tillich: "Conscience in Western Thought and the Idea a Transmoral Conscience". Sonderdruck aus: Crozer Quarterly, Vol. XXII, Nr. 4, Oktober 1945, 6 Blatt; Max Horkheimer: Programm einer Intereuropäischen Akademie, 1944/45 (?); 1. Typoskriptfassungen, englisch. a) Typoskript, 18 Blatt b) Typoskript mit handschriftlicher Korrektur von Theodor W. Adorno (GS 12, S.195-213), 18 Blatt c) Typoskript (Kopie) mit handschriftliche Korrektur, 18 Blatt (Kopie 1989 aus der Hoover Institution, Standford, California) d) Typoskript mit eigenhändiger Korrektur, 17 Blatt e) Korrektur-Teilstücke, Typoskripte mit eigenhändiger Korrektur, 2 Blatt; 2. Zeitungsausschnitt 1944, 1 Blatt;

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Benzene was studied in its target organ of effect, the bone marrow, with the micronucleus test and metaphase chromosomal analysis. Groups of 5 or 10, male and female CD-1 mice were treated with one or two p.o. or i.p. doses of benzene (440 mg/kg) or toluene (430, 860 or 1720 mg/kg) or both, and sacrificed 30 or 54h after the first dose. Benzene-treated animals were pretreated with phenobarbital (PB), 3-methylcholanthrene (3MC), (beta)-naphthoflavone ((beta)NF), SKF-525A, or Aroclor 1254. Toluene showed no clastogenic activity and reduced the clastogenic effect of co-administered benzene. None of the pretreatments protected against benzene clastogenicity. 3MC and (beta)NF greatly promoted benzene myeloclastogenicity. Dose response curves for benzene myeloclastogenicity were much steeper with 3MC induction than without. Micronuclei (MN) were 4-6 times higher by p.o. than i.p. benzene administration. This was not due to bacterial flora since no difference was found between germ-free and conventional males gavaged with benzene. A sensitive high-pressure liquid chromatographic method was developed and used to explore the relation between metabolic profiles of benzene in urine and MN after various pretreatments. Phenol (PH), trans-trans-muconic acid (MA) and hydroquinone (HQ) in the 48h male mouse urine accounted, respectively, for 12.8-22.8, 1.8-4.7 and 1.5-3.7% of the single oral dose of benzene (880, 440 and 220 mg/kg). Catechol (CT) was seen in trace amounts. MA was identified by ultraviolet and infrared spectroscopy and elemental analysis. Urinary metabolites--especially MA, HQ, and phenol glucuronide--correlated well with MN and were dependent on both the dose and the metabolism of benzene. Benzene metabolism was most inducible by cytochrome P-448 enzyme inducers, by p.o. > i.p., in males > females, and inhibited by toluene. Ph, CT or HQ administered p.o., 250, 150 and 250 mg/kg, respectively, or at 150 mg/kg x 2 after 3MC pretreatment, failed to reproduce the potent myeloclastogenicity of benzene. In fact, only HQ was mildly clastogenic. ^

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Strontium isotope stratigraphy was used to date five discrete horizons within CRP-1. Early and late Quaternary (0.87-1.3 Ma and 0-0.67 Ma respectively) age sediments overlie a major sequence boundary at 43.15 meters below sea floor (mbsf). This hiatus is estimated to account for ~16 m.y. of missing section. Early Miocene (16.6-~20.8-25 Ma) age deposits below this boundary are in turn cut by multiple erosion surface representing hiatus is of between 0.2 and 1.2 m.y. Estimated minimum sedimentation rates range between 0.9 and 2.8 cm/k.y. in the Quaternary, and 1.5 and 6.4 cm/ky in the lower Miocene.

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Obtaining long, continuous, and undisturbed sections of unconsolidated Neogene deep sea sedimentary sections has been limited by (1) practical length of piston cores to about 30 meters and (2) disturbance of sediment by rotary drilling with Glomar Challenger. The relatively high deposition rates of late Neogene sediments in the North Atlantic and in the Caribbean in particular has limited penetration, with conventional piston coring, to sediments not much older than late Pliocene in the Atlantic and not even through the late Pleistocene in the Caribbean. Rotary drilling has penetrated much older sediments in both areas, but the cores suffered extensive drilling disturbance that seriously degrades the Paleomagnetism of the material. Utilization of the hydraulic piston corer on the Challenger combines the advantage of a generally undisturbed recovery and great penetration to produce long, relatively undisturbed sections of late Neogene and Quaternary sediments suitable for paleomagnetic studies. In this chapter we present paleomagnetic data from Site 502. We tried to determine relative azimuthal orientation of successive cores (see Introduction for details). Because the low latitude of the site meant a small (inclination of about 22°) vertical component of magnetization, reversals of magnetization could easily be detected only in changes in the horizontal component, as 180° shifts in the declination direction of magnetization. Based on information from the core orienting device, a fiducial line was drawn the length of each core prior to cutting it into the standard 1.5 meter sections.

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Small glassy spheres, ellipsoids, teardrops, cylinders and dumbbells occur in large numbers in Tertiary deep sea clays cored in the northeastern Pacific by the Deep Sea Drilling Project. These objects morphologically resemble microtektites, but have the composition of an oceanic tholeiite. On the basis of their composition and stratigraphic relationship it is considered that they are of volcanic origin and most likely have been formed in deep water by submarine volcanic processes.

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Probable in-situ manganese deposits larger than 1 cm in diameter buried in ODP/DSDP cores were selected for study after examining previous descriptions of the manganese deposits in site reports and the ODP data base. Most of the selected samples from 11 cores occur at or just above sedimentary hiatuses or in slowly deposited sediments and are overlain by rapidly deposited sediments of biogenic, terrigenous or volcanogenic origin. The changes in sedimentation recorded in the lithostratigraphic sections around these deposits are closely related to changes in tectonic evolution, deep water circulation or biological productivity at the sites. The similarity in composition and structure of the buried deposits to those of the modern manganese nodules and crusts with no evidence of post-depositional change suggest that buried manganese deposits may be used as indicators of past sedimentary conditions during which they formed. Their major components are hydrogenetic and earlydiagenetic manganese minerals as well as detrital minerals. The characteristics of these manganese deposits suggests that similar processes of deposition have taken place since the Paleogene or older.

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During the summer of 2003, a ground-penetrating radar survey around the North Greenland Icecore Project (NorthGRIP) deep ice-core drilling site (75°06' N, 42°20' W; 2957 m a.s.l.) was carried out using a shielded 250 MHz radar system. The drill site is located on an ice divide, roughly 300 km north-northwest of the summit of the Greenland ice sheet. More than 430 km of profiles were measured, covering a 10 km by 10 km area, with a grid centered on the drilling location, and eight profiles extending beyond this grid. Seven internal horizons within the upper 120 m of the ice sheet were continuously tracked, containing the last 400 years of accumulation history. Based on the age-depth and density-depth distribution of the deep core, the internal layers have been dated and the regional and temporal distribution of accumulation rate in the vicinity of NorthGRIP has been derived. The distribution of accumulation shows a relatively smoothly increasing trend from east to west from 145 kg/m**2/a to 200 kg/m**2/a over a distance of 50 km across the ice divide. The general trend is overlain by small-scale variations on the order of 2.5 kg/m**2/a/km, i.e. around 1.5% of the accumulation mean. The temporal variations of the seven periods defined by the seven tracked isochrones are on the order of +-4% of the mean of the last 400 years, i.e. at NorthGRIP ±7 kg/m**2/a. If the regional accumulation pattern has been stable for the last several thousand years during the Holocene, and ice flow has been comparable to today, advective effects along the particle trajectory upstream of NorthGRIP do not have a significant effect on the interpretation of climatically induced changes in accumulation rates derived from the deep ice core over the last 10 kyr.