Efeitos esqueléticos e dentários decorrentes da expansão rápida maxilar

This study evaluated the maxillary transversal changes caused by the rapid maxillary expansion (RME) accomplished by Hyrax appliance. Sixteen children from both genders were selected and treated, with ages between 7.7 to 10.8 years, who presented unilateral or bilateral posterior crossbite. Postero-anterior radiographs were taken at the beginning of the treatment, end and post-retention period. The treatment promoted an average opening of 8.8 mm of IMD (intermolar distance), 2.33 mm of IAD (interapex distance) and none of IID (interincisal distance). At the end of retention period, relapse was observed, with a decrease of 4.3 mm of IMD, 1.23 mm of IAD, a non-significant enlargement of IID (0,38 mm).These results confirm the significant influence of Hyrax appliance on transverse dimensions, represented by enlargement of IMD and IAD and its effectiveness to solve posterior crossbites.

Uso de um distrator ósseo dentoimplantossuportado, feito a partir de tornos expansores convencionais, na reabilitação oral

Osteodistraction is a clinical reality, available in the last decades for the resolution of large bone deficiencies, in cases that there are pre-existing, but misplaced implants and teeth. The aims of thearticle is to present a case report in which a new possibility for bone distraction, based on tooth-implant bone distractors, made from standard orthodontic expansion-screws, was used in an area where there was an extensive need of alveolar bone and aesthetical recovery, allied to teeth and dental implant misplacement. This technique presented good clinical results, associated to effective simplicity and low cost, becoming viable clinical solution for bone tissue augmentation and aesthetical optimization. In resume, it is possible to say that the suggested technique achieved its objectives, improving the hard and soft tissue profile, whilst allowing completion of oral rehabilitation.

Galectin-1 exerts inhibitory effects during DENV-1 infection

Dengue virus (DENV) is an enveloped RNA virus that is mosquito-transmitted and can infect a variety of immune and non-immune cells. Response to infection ranges from asymptomatic disease to a severe disorder known as dengue hemorrhagic fever. Despite efforts to control the disease, there are no effective treatments or vaccines. In our search for new antiviral compounds to combat infection by dengue virus type 1 (DENV-1), we investigated the role of galectin-1, a widely-expressed mammalian lectin with functions in cell-pathogen interactions and immunoregulatory properties. We found that DENV-1 infection of cells in vitro exhibited caused decreased expression of Gal-1 in several different human cell lines, suggesting that loss of Gal-1 is associated with virus production. In test of this hypothesis we found that exogenous addition of human recombinant Gal-1 (hrGal-1) inhibits the virus production in the three different cell types. This inhibitory effect was dependent on hrGal-1 dimerization and required its carbohydrate recognition domain. Importantly, the inhibition was specific for hrGal-1, since no effect was observed using recombinant human galectin-3. Interestingly, we found that hrGal-1 directly binds to dengue virus and acts, at least in part, during the early stages of DENV-1 infection, by inhibiting viral adsorption and its internalization to target cells. To test the in vivo role of Gal-1 in DENV infection, Gal-1-deficient-mice were used to demonstrate that the expression of endogenous Galectin-1 contributes to resistance of macrophages to in vitro-infection with DENV-1 and it is also important to physiological susceptibility of mice to in vivo infection with DENV-1. These results provide novel insights into the functions of Gal-1 in resistance to DENV infection and suggest that Gal-1 should be explored as a potential antiviral compound.

Monocyte migration driven by galectin-3 occurs through distinct mechanisms involving selective interactions with the extracellular matrix

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Teoria e metodologia na escrita da História do Brasil: Afonso de Taunay e a Academia Brasileira de Letras

The history of historiography in recent decades has the breathing space needed in the concerns of historians and has been transformed into a research field with its own issues. Uploaded this in perspective, this paper aims to understand how aspects of the theory of history and methodology have been addressed by Afonso de Escragnolle Taunay (1876-1958). We selected the letters exchanged by the author, the speeches of acceptance at the ABL, some articles and books produced by Taunay in the 1930s. In the first decades of the twentieth century, when it sought to define the historiography and its limits in both the literature and social science sources, the subjectivity is presented as the final decision making of the author, especially those related to the new site production Taunay, the Brazilian Academy of Letters.

Ophthalmic parameters in adult Shih Tzu dogs

Ocular surface diseases are often diagnosed in brachycephalic dogs. The ophthalmic parameters of the Shih Tzu dogs are evaluated in this study since this breed is among the most commonly affected by these diseases. In this study, ophthalmic parameters of this breed were partly studied under physical restraint. Schirmer tear test, breakup time test, aesthesiometry, biomicroscopy, non-contact specular microscopy, laser flaremetry, applanation tonometry, ultrasonography and ophthalmoscopy were carried in 48 eyes of 24 male and female dogs, aged from two to four years, weighing between 5 and 10kg. All dogs were from a breeding kennel. Descriptive statistics were applied to the data. Mean and standard error for Schirmer tear test was 26.145±0.803mm min-1; breakup time test, 13.668±0.538s; and aesthesiometry, 2.395±0.071cm. The biomicroscopy evaluation showed that 70.83% of the eyes had medial entropion; 42% caruncular trichiasis; 33% distichiasis, 27% mild paracentral corneal opacity; and 13% corneal melanosis. Mean and standard error for endothelial cell density was 2221.591±20.161cells mm-2; endothelial cell hexagonality, 63.770±1.805%; endothelial cell area, 451.895±4.179mm2; central corneal thickness, 0.490±0.007 mm; laser flaremetry, 1.720±0.216PC ms-1; applanation tonometry, 16.118±0.460mmHg; axial length, 20.255±0.134mm; lens thickness, 6.624±0.031mm; anterior chamber, 4.064±0.109mm; and vitreous chamber, 9.565±0.054mm. Ophthalmoscopy findings were not different from previous reports for other breeds. The results showed that the ophthalmic Shih Tzu parameters did not differ from other breeds according to data in the literature, except for the breakup time and Cochet-Bonnet aesthesiometry.

Chemical analysis and Vickers hardness of orthodontic mini-implants

Orthodontic mini-implants are used in clinical practice to provide efficient and aesthetically-pleasing anchorage. AIM: To evaluate the hardness Vickers hardness and chemical composition of mini-implant titanium alloys from five commercial brands. METHODS: Thirty self-drilling mini-implants, six each from the following commercial brands, were used: Neodent NEO, Morelli MOR, Sin SIN, Conexão CON, and Rocky Mountain RMO. The hardness and chemical composition of the titanium alloys were performed by the Vickers hardness test and energy dispersive X-ray spectroscopy, respectively. RESULTS: Vickers hardness was significantly higher in SIN implants than in NEO, MOR, and CON implants. Similarly, VH was significantly higher in RMO implants than in MOR and NEO ones. In addition, VH was higher in CON implants than in NEO ones. There were no significant differences in the proportions of titanium and aluminum in the mini-implant alloy of the five commercial brands. Conversely, the proportion of vanadium differed significantly between CON and MOR/NEO implants. CONCLUSIONS: Mini-implants of different brands presented distinct properties of hardness and composition of the alloy.

Modelo de poços quânticos para a transferência de elétrons

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Ocorrência da raiva e de anticorpos antirrábicos em morcegos do noroeste de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Pinóquio, o leitor

Este estudo tem como objetivo principal analisar os vários leitores presentes no clássico Pinóquio do escritor italiano Collodi. Do leitor que apenas consegue aprender o código da escrita e a sintaxe que comanda esse código, ou no dizer de Manguel (2009,p.41) - o processo mecânico de aprender o código da escrita na qual está codificada a memória de uma sociedade - ao leitor que consegue entender sua identidade e a sociedade que o cerca, ou também no dizer de Manguel (2009,p.41) - o aprendizado de como as inscrições nesse código servem para conhecer de maneira profunda, imaginativa e prática nossa identidade e a do mundo que nos cerca, onde encaixar o tipo de leitor que Collodi cria para seu personagem?. É válido, ainda, indagar quais são os outros leitores na obra Pinóquio e o que representariam? Tecer a leitura e a releitura de uma obra permite essas reflexões sobre a educação e o processo humanizador da literatura (Cândido,1989,p.112), proporcionando assim uma viagem de introspecção (auto-conhecimento),e a exploração e leitura do mundo, fatores estes fundamentais na formação da subjetividade e da autonomia de pensamento do sujeito

High precision and selectivity for quantitation of enrofloxacin and ciprofloxacin in five chicken tissues using solid phase extraction and ESI LC-MS/MS for application in monitoring residues

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effect of thermocycling on roughness of nanofill, microfill and microhybrid composites

Objective. This study aimed to investigate the surface roughness of composite resins subjected to thermal cycles procedure. Materials and methods. Two microfill, four microhybrid and four nanofill composites were used. The surface roughness (Ra) was initially measured in a profilometer using a cut-off 0f 0.25 mm, after 3000 and 10,000 thermal cycles. Data were subjected to ANOVA and Fischer's test (alpha = 0.05). Results. Overall, 3000 thermal cycles increased the surface roughness values for all materials and there was a trend in all groups to decrease the roughness after 10,000 thermal cycles. Conclusions. The composition of material, including the type of organic matrix, could be more relevant to roughness maintenance over time than the general behavior of composites based on particles fillers. The maintenance of smooth surface in resin-based composite restorations is totally dependent of organic composition of the material.

Metalloproteinase inhibition protects against reductions in circulating adrenomedullin during lead-induced acute hypertension

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)