Multiparametric brainstem segmentation using a modified multivariate mixture of Gaussians

The human brainstem is a densely packed, complex but highly organised structure. It not only serves as a conduit for long projecting axons conveying motor and sensory information, but also is the location of multiple primary nuclei that control or modulate a vast array of functions, including homeostasis, consciousness, locomotion, and reflexive and emotive behaviours. Despite its importance, both in understanding normal brain function as well as neurodegenerative processes, it remains a sparsely studied structure in the neuroimaging literature. In part, this is due to the difficulties in imaging the internal architecture of the brainstem in vivo in a reliable and repeatable fashion. A modified multivariate mixture of Gaussians (mmMoG) was applied to the problem of multichannel tissue segmentation. By using quantitative magnetisation transfer and proton density maps acquired at 3 T with 0.8 mm isotropic resolution, tissue probability maps for four distinct tissue classes within the human brainstem were created. These were compared against an ex vivo fixated human brain, imaged at 0.5 mm, with excellent anatomical correspondence. These probability maps were used within SPM8 to create accurate individual subject segmentations, which were then used for further quantitative analysis. As an example, brainstem asymmetries were assessed across 34 right-handed individuals using voxel based morphometry (VBM) and tensor based morphometry (TBM), demonstrating highly significant differences within localised regions that corresponded to motor and vocalisation networks. This method may have important implications for future research into MRI biomarkers of pre-clinical neurodegenerative diseases such as Parkinson's disease.

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Contient : 1° « La Vie des sainz Peres », traduction comprenant ; 1 « Li Prologues », en vers, adressé à Blanche de Navarre, comtesse de Champagne ; 2 « La Viè des sainz Peres » ; 2° « Les Voiages que saint Antoine fist en la terre d'outremer » ; 3° « L'Estoire de Balaam et de Josaph[a]t » [de St JEAN DAMASCENE] ; 4° « L'Avenement Antecrist » ; 5° « Si comme Nostre-Sires vendra jugier le monde » ; 6° « L'Asumptiom Nostre Dame » ; 7° Recétte « ffor to makin aqua vite »

Réflexions d'un souscripteur de l'Encyclopédie , sur le procès intenté aux libraires associés à cet ouvrage, par M. Luneau de Boisjermain

[Factum (Encyclopédie (Affaire de l'))]

Les quatre livres des rois : traduits en français du XIIe siècle. suivis d'un Fragment de moralités sur Job et d'un Choix de sermons de Saint Bernard / publiés par M. Le roux de Lincy,...

[Bible. A.T.. Samuel (ancien français). 1841]

Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF.

The macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that recently emerged as an attractive therapeutic target for a variety of diseases. A diverse panel of fully human anti-MIF antibodies was generated by selection from a phage display library and extensively analyzed in vitro. Epitope mapping studies identified antibodies specific for linear as well as structural epitopes. Experimental animal studies revealed that only those antibodies binding epitopes within amino acids 50-68 or 86-102 of the MIF molecule exerted protective effects in models of sepsis or contact hypersensitivity. Within the MIF protein, these two binding regions form a β-sheet structure that includes the MIF oxidoreductase motif. We therefore conclude that this β-sheet structure is a crucial region for MIF activity and a promising target for anti-MIF antibody therapy.