In vitro exposure of community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains to vancomycin: does vancomycin resistance occur?

Vancomycin is the preferred parenteral antibiotic for the treatment of all methicillin-resistant Staphylococcus aureus (MRSA) infections, including the newly emerging community-associated MRSA (CA-MRSA) infections. Vancomycin-intermediate nosocomial MRSA strains have developed in vitro and in vivo after exposure to vancomycin. The aim of this study was to determine whether daily serial passage of CA-MRSA strains onto vancomycin-supplemented agar selects for the development of vancomycin resistance. Twelve clinical isolates of the six commonest Australian and US strains of CA-MRSA were serially passaged daily for 25 days onto brain-heart infusion agar plates supplemented with 4 mu g/mL vancomycin and then subcultured for a further 15 days onto antibiotic-free agar to assess the stability of the resistance phenotype. Minimum inhibitory concentrations (MICs) were determined by standard Etest every 5 days from day 0 to day 40. Serial passaging resulted in increased MICs in all strains but the rises were modest, with an increase of < 2 doubling dilutions. All strains remained vancomycin Susceptible throughout the experiment according to Clinical Laboratory Standards Institute criteria. Crown Copyright (c) 2005 Published by Elsevier B.V. on behalf of International Society of Chemotherapy. All rights reserved.

25 DE DEZEMBRO: SIMBOLISMOS E APROXIMAÇÕES ENTRE OS DEUSES APOLO, HÉLIOS, MITRA E JESUS CRISTO UMA ANÁLISE EM MITOLOGIA COMPARADA

O Solstício de Inverno demonstra, a importância do sol como elemento proporcionador da vida, em inúmeras culturas européias e orientais. Os gregos, de modo um tanto distinto de outros povos, constituíram sua mítica, cultuando dois deuses solares, que se alternaram nas crenças e nos cultos deste povo: Hélios e Apolo. Os latinos, que absorvem parte da mítica grega, cultuando estas divindades, trazem progressivamente, outro deus sol para ser adorado: a divindade persa Mitra. O cristianismo que migra de sua origem local e cultural, para as cidades latinas, principalmente Roma, no primeiro século, provoca e enfrenta um combate constante com as crenças pagãs, principalmente as crenças solares, conseguindo progressivamente, uma supremacia, até o ponto em que as religiões não cristãs, são suprimidas, processo iniciado com o imperador Constantino e finalizado com Teodósio. Entretanto, o imaginário das culturas derrotadas pelo cristianismo, não consegue ser eliminado completamente; os deuses pagãos se instalam, em diversos elementos da nova religião, como na comemoração do nascimento de Jesus Cristo, defendido pela igreja, como acontecido em 25 de dezembro. O período na verdade, era milenarmente anterior ao surgimento do cristianismo, como data do nascimento do deus Mitra, e próximo do Solstício de Inverno, onde eram cultuados os deuses Apolo e Hélios, transformados na cultura latina no culto ao Sol Invicto.

A COMUNICAÇÃO PODE SALVAR VIDAS: ALERTAS ANTECIPADOS DE EMERGÊNCIAS CLIMÁTICAS PELA TELEVISÃO DIGITAL INTERATIVA BRASILEIRA

Alertas Antecipados de Emergência são elementos importantes na redução de riscos de desastres, evitando a perda de vidas e reduzindo seu impacto econômico e material. Dentre os meios de comunicação mais eficazes para geração de alertas antecipados, a televisão digital com sua capacidade de emissão de um para muitos e ainda com suas possibilidades de gerar informações reativas com dados enviados pelo mesmo sinal de TV é, no momento, o estado da arte para ajudar a população em situações de risco, comprovado através de estudos comparativos entre os sistemas de alerta de emergência existentes hoje em todo o mundo. Neste trabalho são comparados os sistemas japonês e norte-americano, sendo que os referenciais teóricos apresentados focalizam o processo comunicacional de uma informação de emergência, a partir de diversas teorias que fundamentam o processo de comunicação em situações de crise, com os quais chegou-se à conclusão de que a tecnologia de televisão Digital Brasileira, juntamente com a infraestrutura essencial para detecção de riscos e confiabilidade para a geração de alertas antecipados já existente, dispõe de todo o ferramental necessário para a criação de um sistema nacional. Por fim são apresentadas as indicações iniciais para a criação de um modelo para uma comunicação eficaz e efetiva de informações de emergência destinado à população brasileira.

Trade-offs in customer–employee focus:implications on boundary-spanning capabilities

In pursuing their particular strategic goals, organisations place differential emphasis in their activities on employees and customers. Those who focus predominantly on employees see them as key resources contributing to successful achievement of goals, while those who focus on customers believe that customer commitment is the prime source of financial prosperity and competitive advantage. In all firms, there is potential for conflict and subsequent trade-offs in the emphasis placed on employee resources and customers. This paper investigates the implications of these potential trade-offs on firms’ boundary-spanning capabilities (those capabilities that enable firms to interact effectively with their customers, their suppliers, their strategic allies and others in their business networks) in European and Australasian markets. The results suggest that those companies which achieve a strong but balanced focus on both employees and customers have heightened boundary-spanning capabilities. The comparison between UK and Australian businesses indicates that the balance is more highly developed in Australasian than European (UK) markets.

Trade-offs in customer-employee focus:Implications on boundary-spanning capabilities

In pursuing their particular strategic goals, organisations place differential emphasis in their activities on employees and customers. Those who focus predominantly on employees see them as key resources contributing to successful achievement of goals, while those who focus on customers believe that customer commitment is the prime source of financial prosperity and competitive advantage. In all firms, there is potential for conflict and subsequent trade-offs in the emphasis placed on employee resources and customers. This paper investigates the implications of these potential trade-offs on firms' boundary-spanning capabilities (those capabilities that enable firms to interact effectively with their customers, their suppliers, their strategic allies and others in their business networks) in European and Australasian markets. The results suggest that those companies which achieve a strong but balanced focus on both employees and customers have heightened boundary-spanning capabilities. The comparison between UK and Australian businesses indicates that the balance is more highly developed in Australasian than European (UK) markets. © 2004 by The Haworth Press, Inc. All rights reserved.

The politics of the new Germany

The Politics of the New Germany continues to provide the most comprehensive, authoritative and up-to-date textbook on contemporary German Politics. The text takes a new approach to understanding politics in the post-unification Federal Republic. Assuming only elementary knowledge, it focuses on a series of the most important debates and issues in Germany today with the aim of helping students understand both the workings of the country's key institutions and some of the most important policy challenges facing German politicians. For this second edition, the content has been comprehensively updated throughout, augmented by additional factboxes and data, and features new material on: •Grand coalition •Lisbon treaty •Constitutional court •Financial crisis •Reform of social policy •Afghanistan. Written in a straightforward style by three experts, each of the chapters draws on a rich variety of real-world examples. In doing so, it highlights both the challenges and opportunities facing policy-makers in such areas as foreign affairs, economic policy, immigration, identity politics and institutional reform. The book also takes a bird’s-eye view of the big debates that have defined German politics over time, regardless of which political parties happened to be in power. It pinpoints three key themes that have characterised German politics over the last sixty years; reconciliation, consensus and transformation. The book is a comprehensive, yet highly accessible, overview of politics in 21st Century Germany and should be essential reading for students of politics and international relations, as well as of European and German studies.

Europa i świat zachodni:szkodliwe dla gospodarki niedostrzegane lub lekceważone zjawiska

The paper presents an abbreviated version of the second part of the report on problems of Europe, prepared by a team of teachers at the University of Information Technology and Management in Rzeszow, Poland. We stress therein that the hotly debated problems of the Eurozone and the global financial crisis and its aftermath are, at best, medium-term ones, while real issues Europe faces are of the long-term nature and result from policies pursued for decades. Their consequences are also long-term – and increasingly harmful. Our diagnosis is as follows. Long-term problems related to the increasing burden of the welfare state and its side effects, like the slowing economic growth rate, are not subject to serious policy debates. It applies to both traditional elites from parties belonging to the moderate political spectrum, and to anti-elites on both extremes. Both elites and anti-elites reject the reality as a starting point to developing corrective policy measures. Our economic analysis has revealed that incentives to create wealth in old Western countries have been weakening for a long time. Yet, without deep cuts in public (especially welfare) expenditures and accompanying institutional reforms, economic performance of European (and generally Western) economies is going to worsen over time. The chances of continued stagnation in the next 5–10 years are very high. Finally, we look at the socio-psychological behavioral framework of the ever-expanding welfare state. We point at the phenomenon of the learned helplessness which appears as a result of the people’s lacking perception of linkages between their actions and economic results of these actions. We interpret it as a consequence of the welfare state. It further weakens the prospects for successful reforms and the resultant avoidance of the long-term stagnation.

What the newspapers say about medication adherence:a content analysis

Background - This study investigates the coverage of adherence to medicine by the UK and US newsprint media. Adherence to medicine is recognised as an important issue facing healthcare professionals and the newsprint media is a key source of health information, however, little is known about newspaper coverage of medication adherence. Methods - A search of the newspaper database Nexis®UK from 2004–2011 was performed. Content analysis of newspaper articles which referenced medication adherence from the twelve highest circulating UK and US daily newspapers and their Sunday equivalents was carried out. A second researcher coded a 15% sample of newspaper articles to establish the inter-rater reliability of coding. Results - Searches of newspaper coverage of medication adherence in the UK and US yielded 181 relevant articles for each country. There was a large increase in the number of scientific articles on medication adherence in PubMed® over the study period, however, this was not reflected in the frequency of newspaper articles published on medication adherence. UK newspaper articles were significantly more likely to report the benefits of adherence (p = 0.005), whereas US newspaper articles were significantly more likely to report adherence issues in the elderly population (p = 0.004) and adherence associated with diseases of the central nervous system (p = 0.046). The most commonly reported barriers to adherence were patient factors e.g. poor memory, beliefs and age, whereas, the most commonly reported facilitators to adherence were medication factors including simplified regimens, shorter treatment duration and combination tablets. HIV/AIDS was the single most frequently cited disease (reported in 20% of newspaper articles). Poor quality reporting of medication adherence was identified in 62% of newspaper articles. Conclusion - Adherence is not well covered in the newspaper media despite a significant presence in the medical literature. The mass media have the potential to help educate and shape the public’s knowledge regarding the importance of medication adherence; this potential is not being realised at present.

Matematikaoktatás a bolognai típusú gazdasági képzésekben (Maths instruction in Bologna-type economics tuition)

A gazdálkodási és közgazdasági alap- és mesterszakok tanterveiben számos matematikai tárgy szerepel. A kétciklusú bolognai képzésre történő áttérés Európa-szerte igényelte a matematikaoktatás szerkezetének, mennyiségének és mélységének újragondolását a gazdálkodási és közgazdasági képzési területeken. Mivel az átállás országonként és intézményenként párhuzamosan és jelentős mértékben egymástól függetlenül ment végbe, egyetemenként számos eltérő megoldással találkozhatunk. Az egyetemek operatív tanterveit és tantárgyi adatlapjait felhasználva, utólagosan már összehasonlítható az egyes egyetemek matematikaoktatása. A tanulmány a matematika közgazdaságtanban betöltött szerepének áttekintése után a vezető európai egyetemek és négy magyar egyetem gazdálkodási és közgazdasági képzésén folyó matematikaoktatásának összehasonlító elemzése alapján arra az alapvető következtetésre jut, hogy Magyarországon a vizsgált képzési területen a matematikaoktatás mennyiségileg és minőségileg kritikus szintre süllyedt. / === / The basic and master's curricula for business and economics include plenty of mathematics subjects. Business and economics courses had to be rethought when the change was made across Europe to the two-cycle Bologna system. This change took place simultaneously but independently in each country and institution, so that notably different solutions can be found in each university. A retrospective comparison of maths instruction in various universities can be made by examining their operative syllabuses and subject data-sheets. The study reviews the part mathematics plays in economics, then uses comparative analysis of the maths teaching in business and economics courses at leading European and four Hungarian universities to reach a general conclusion: maths teaching in Hungary, in the field examined, has sunk to a critical level, in terms of quality and quantity.

Food Retail Chains: Hungary in the EU

The role of retail chains is signifi cant, not only in the European but also in the Hungarian market. Major changes can be seen in the food trade, and hypermarkets and supermarkets are becoming more widespread, which has an international tendency. We are able to see the transformation of trade structure and changes in customer behaviour. On the customers’ side, this means newer demands on retail chains, which fact greatly determines the location and shape of stores. In Hungary, the presence of small shops is still signifi cant, in accordance with European and international trends; yet on the basis of turnover, the increasing dominance of larger sales centres can be seen.

Todo nordeste que couber a gente publica: o The New York Times e as representações do nordeste brasileiro na era da política da boa vizinhança (1933-1945)

The Brazilian Northeast has been a constant subject for journalists of one of the world's leading media companies - The New York Times - between 1933 and 1945. This time, the US government implemented a new foreign policy for Latin America - known as the Good Neighbor Policy. It preached, various points including more respect and attention to the countries south of U.S. borders. Because of her geostrategic importance, Brazil was one of the countries that received the most attention of the bureaucracy and American press. This study investigates the multiple Northeast representations formulated in The New York Times' pages when the Americans were spotlight is on the region. It delineates similarities and differences between the NYT, the press and the governments of the United States and Brazil from the ways of conceiving this particular part of Brazil. Through the analysis of texts, photographs and maps, it is dedicated to establish connections between spaces, press and politics of the 1930s and 1940s. These decades there were relevant changes in the political landscape of both countries that permeated the news, reports and articles of NYT. Circumstances such as the 1935 armed uprisings - known as Communist Conspiracy - the installation and operation of the New State, and especially the Brazilian and US participation in World War II and the bilateral negotiations on the installation of US bases in Brazil were cardinal for the various Northeast images that circulated in the publication. The region was repeatedly subject of correspondent of the New York newspaper in Brazil, Frank M. Garcia, but also present on matters of professionals responsible for various sections: review of books, publishing, tourism, foreign affairs, etc. Along the investigated period, the visions of the region made in the articles published in the newspaper that suffered major metamorphoses. Starting with Northeast of the drought, famine and death recurrent in Brazilian literature to the most dangerous point for hemispheric defense, passing through representations of the American West lawless nineteenth century and the Latin America marked by the dominance of exotic nature and stagnation, a space to be transformed by the US technical knowledge.

Project scoping for lessons learnt to apply to the Celtic Seas marine sub-region

This report involves a formal scoping exercise to identify lessons from a wide range of previous and current project and initiative experiences at the national, regional seas, European and global levels. An inventory of 77 projects and initiatives that are relevant with regard to the key activities proposed by the Celtic Seas Partnership has been compiled, as well as a short-list of 23 of the most pertinent projects, lessons learnt and contact names. This report has identified a number of synergies and collaborative opportunities from other project and initiatives in the Celtic Seas and beyond. It provides a strong starting point to clarify to stakeholders the uniqueness of the Celtic Seas Partnership project and delivers a sound baseline for the other preparatory actions (A2 Stakeholder Mapping and A3 Baseline Analysis for Marine Strategy Framework Directive Implementation) and the implementation actions. Furthermore, this report helps to avoid duplication of effort during the life-span of the project by highlighting what information pertaining to the Celtic Seas MSFD sub-region already exists.

An identity-based motivational model of the effects of perceived discrimination on health-related behaviors

Perceived discrimination is associated with increased engagement in unhealthy behaviors. We propose an identity-based pathway to explain this link. Drawing on an identity-based motivation model of health behaviors (Oyserman, Fryberg, & Yoder, 2007), we propose that erceptions of discrimination lead individuals to engage in ingroup-prototypical behaviors in the service of validating their identity and creating a sense of ingroup belonging. To the extent that people perceive unhealthy behaviors as ingroup-prototypical, perceived discrimination may thus increase motivation to engage in unhealthy behaviors. We describe our theoretical model and two studies that demonstrate initial support for some paths in this model. In Study 1, African American participants who reflected on racial discrimination were more likely to endorse unhealthy ingroup-prototypical behavior as self-characteristic than those who reflected on a neutral event. In Study 2, among African American participants who perceived unhealthy behaviors to be ingroup-prototypical, discrimination predicted greater endorsement of unhealthy behaviors as self-characteristic as compared to a control condition. These effects held both with and without controlling for body mass index (BMI) and income. Broader implications of this model for how discrimination adversely affects health-related decisions are discussed.

El enfoque biográfico en el análisis social : Claves para un estudio de los aspectos teórico-metodológicos de las trayectorias laborales

Este trabajo desarrolla los supuestos que se esconden tras los estudios biográficos, centrándose en los enfoques europeo y norteamericano. Intenta vislumbrar los distintos ámbitos de producción en donde surgieron los fundamentos epistemológicos, teóricos y metodológicos, los cuales enmarcan el análisis de las trayectorias: la centralidad del sujeto, la relación individuo-sociedad, la integración de perspectivas metodológicas y la importancia de la dimensión espacio-temporal. La relevancia de esta tarea radica en que el enfoque biográfico se constituye como telón de fondo en el estudio de las trayectorias laborales. En el primer apartado se indagan los orígenes del uso de biografías en la investigación social; en el segundo y el tercero, se examinan los supuestos centrales del enfoque biográfico y del curso de vida, al encontrar en ellos las raíces que encuadran y dan sentido al estudio de las trayectorias. Por último, se desarrollan los aportes y potencialidades de los estudios con trayectorias laborales a través del análisis de un corpus de investigaciones empíricas producidas en América Latina