G-1 Appeal Activity in the Public Assistance Programs, February 2007

G-1 - Appeal Activity in the Public Assistance Programs - February 2007

Kermit interacts with gαo, vang, and motor proteins in Drosophila planar cell polarity.

In addition to the ubiquitous apical-basal polarity, epithelial cells are often polarized within the plane of the tissue - the phenomenon known as planar cell polarity (PCP). In Drosophila, manifestations of PCP are visible in the eye, wing, and cuticle. Several components of the PCP signaling have been characterized in flies and vertebrates, including the heterotrimeric Go protein. However, Go signaling partners in PCP remain largely unknown. Using a genetic screen we uncover Kermit, previously implicated in G protein and PCP signaling, as a novel binding partner of Go. Through pull-down and genetic interaction studies, we find that Kermit interacts with Go and another PCP component Vang, known to undergo intracellular relocalization during PCP establishment. We further demonstrate that the activity of Kermit in PCP differentially relies on the motor proteins: the microtubule-based dynein and kinesin motors and the actin-based myosin VI. Our results place Kermit as a potential transducer of Go, linking Vang with motor proteins for its delivery to dedicated cellular compartments during PCP establishment.

G-1 Appeal Activity in the Public Assistance Programs, April 2007

G-1 - Appeal Activity in the Public Assistance Programs - April 2007

G-1 Appeal Activity in the Public Assistance Programs, March 2007

G-1 - Appeal Activity in the Public Assistance Programs - March 2007

Alpha rhythm and hypofrontality in schizophrenia

OBJECTIVE: To reveal the EEG correlates of resting hypofrontality in schizophrenia (SZ). METHOD: We analyzed the whole-head EEG topography in 14 patients compared to 14 matched controls by applying a new parameterization of the multichannel EEG. We used a combination of power measures tuned for regional surface mapping with power measures that allow evaluation of global effects. RESULTS: The SZ-related EEG abnormalities include i) a global decrease in absolute EEG power robustly manifested in the alpha and beta frequency bands, and ii) a relative increase in the alpha power over the prefrontal brain regions against its reduction over the posterior regions. In the alpha band both effects are linked to the SZ symptoms measured with Positive and Negative Symptom Scales and to chronicity. CONCLUSION: As alpha activity is related to regional deactivation, our findings support the concept of hypofrontality in SZ and expose the alpha rhythm as a sensitive indicator of it.

G-1 Appeal Activity in the Public Assistance Programs, May 2007

G-1 - Appeal Activity in the Public Assistance Programs - May 2007

Récréations dramatiques à l'usage des écoles, patronages, pensionnats / par un ami de la jeunesse. A. M. D. G.. Le tambour nocturne. Le dissipateur. Le jeune homme à l'épreuve. Herménégilde. Les sept dormants

Comprend : Le tambour nocturne ou l'esprit frappeur : [comédie en 5 actes] - Le dissipateur : [comédie en 3 actes] - Le jeune homme à l'épreuve : [comédie en 4 actes] - Herménégilde martyr : [tragédie en 5 actes] - Les sept dormants : [comédie en 5 actes]