Concomitant Cisplatin and Hyperfractionated Radiotherapy in Locally Advanced Head and Neck Cancer: Ten-year Follow-up of a Randomized Phase III Trial (SAKK 10/94)

Purpose/Objective(s): To analyze the long-term outcome of treatment with concomitant cisplatin and hyperfractionated radiotherapy in locally advanced head and neck cancer compared with hyperfractionated radiotherapy alone.Materials/Methods: From July 1994 to July 2000 a total of 224 patients with squamous cell carcinoma of the head and neck were randomized to either hyperfractionated radiotherapy (median dose 74.4 Gy; 1.2 Gy twice daily) or the same radiotherapy combined with two cycles of concomitant cisplatin (20mg/m2 for 5 consecutive days of weeks 1 and 5). The primary endpoint was time to any treatment failure; secondary endpoints were locoregional failure, metastatic failure, overall survival, and late toxicity assessed according to RTOG criteria. The trial was registered at the National Institutes of Health (www.clinicaltrials.gov; identifier number: NCT00002654).Results: Median follow-up was 9.5 years (range, 0.1 - 15.4 years). Median time to any treatment failure was not significantly different between treatment arms (p = 0.19). Locoregional control (p\0.05), distant metastasis-free survival (p = 0.02) and cancer specific survival (p = 0.03) were significantly improved in the combined treatment arm, with no difference in late toxicity between treatment arms. However, overall survival was not significantly different (p = 0.19). Conclusions: After long-term follow-up combined treatment with cisplatin and hyperfractionated, radiotherapy maintained an improved locoregional control, distant metastasis-free survival, and cancer specific survival as compared to hyperfractionated radiotherapy alone with no difference in late toxicity.Author Disclosure: P. Ghadjar, None; M. Simcock, None; G. Studer, None; A.S. Allal, None; M. Ozsahin, None; J. Bernier, None; M. To¨ pfer, None; F. Zimmermann, None; C. Glanzmann, None; D.M. Aebersold, None.

Senegalin presidentti Leopold Senghorin vierailu Suomeen 7.-10.5.1970 (Tasavallan Presidentin päivällispuhe presidentti Senghorin vierailun yhteydessä 8.5.1970 = Discours du President de la Republique Urho Kekkonen au diner offert a M. Senghor, President de la Republique du Senegal, le 8 mai 1970)

Puhe

Helsinki 7.10.1924

Kirje

Evaluación de la población de concha de abanico (Argopecten purpuratus) en el área de Callo 10 - 16 de Mayo de 1995. Informe preliminar

Da a conocer los resultados preliminares de la evaluación de la población de concha de abanico en el área de Callao, efectuada entre el 10 y 16 de mayo de 1995, con la finalidad de estimar la magnitud del stock y determinar las características del recurso en relación al ambiente marino. Para el estudio, se empleó el método de muestreo estratificado al azar. Como resultado de la investigación, se obtiene que la disponibilidad y biomasa del recurso fue baja por lo que se recomienda intensificar el control de la talla mínima de extracción.

Aurooran sairaala 4/10 1967 Kunnallisneuvos Kyllikki Pohjala

Kirje 4.10.1967

Tasavallan Presidentti Urho Kekkosen vierailu Unkariin 26.9.-1.10.1969 (Tasavallan Presidentin Unkariin saapumispuhe 26.9.1969)

Puhe

Professori L. A. Puntila 30/10 1970

Kirje 30.10.1970